{"id":"fenticonazole","rwe":[{"pmid":"41684522","year":"2025","title":"Innovative dual-functional hybrid cationic PEGylated proniosomes as a smart nano-platform for Boosted vaginal delivery: multi-level in-vitro, ex-vivo, microbiological, and in-vivo studies.","finding":"","journal":"Frontiers in pharmacology","studyType":"Clinical Study"},{"pmid":"41679661","year":"2026","title":"Fenticonazole targets NF-κB p105/p50 to suppress triple-negative breast cancer via ROS-mediated ER stress and apoptosis.","finding":"","journal":"Biochemical pharmacology","studyType":"Clinical Study"},{"pmid":"41487506","year":"2025","title":"Harnessing natural terpenes via PEGylated mucoadhesive vesicles for improved urinary bladder delivery: from in vitro evaluation to in vivo assessment.","finding":"","journal":"Frontiers in pharmacology","studyType":"Clinical Study"},{"pmid":"41015156","year":"2025","title":"Formulation of synergistic theranostic nanoradiopharmaceutical for bacterial infections inflammation using a novel fenticonazole platform: In vitro biological assessment, radioiodination and in vivo biodistribution.","finding":"","journal":"Journal of pharmaceutical sciences","studyType":"Clinical Study"},{"pmid":"40703664","year":"2025","title":"Development and characterization of fenticonazole nitrate-loaded cubogel for the management of vaginal candidiasis.","finding":"","journal":"International journal of pharmaceutics: X","studyType":"Clinical Study"}],"tags":[{"label":"fenticonazole","category":"class"},{"label":"Small Molecule","category":"modality"},{"label":"D01AC12","category":"atc"},{"label":"Active","category":"status"},{"label":"Candidal vulvovaginitis","category":"indication"},{"label":"Anti-Infective Agents","category":"pharmacology"},{"label":"Antifungal Agents","category":"pharmacology"}],"phase":"phase_2","safety":{},"trials":[],"aliases":[],"patents":[],"pricing":[],"allNames":"lomexin","offLabel":[],"synonyms":["fenticonazole nitrate","fenticonazole","lomexin","fenticonazole mononitate","fenizolan"],"timeline":[],"aiSummary":"Lomexin is a small molecule medication used to treat various vaginal infections, including Trichomonal Vaginitis, Bacterial Vaginosis, Candidal Vulvovaginitis, and Mixed Vaginal Infections. It is available in different formulations, including EVEGYN A, EVEGYN B, and Gynomax XL Vaginal Ovule, which have been evaluated in clinical studies for efficacy and safety.","approvals":[],"brandName":"Lomexin","ecosystem":[{"indication":"Candidal vulvovaginitis","otherDrugs":[{"name":"butoconazole","slug":"butoconazole","company":"Bayer"},{"name":"clotrimazole","slug":"clotrimazole","company":""},{"name":"fluconazole","slug":"fluconazole","company":"Pfizer"},{"name":"gentian violet","slug":"gentian-violet","company":""}],"globalPrevalence":null}],"mechanism":{"modality":"Small Molecule","drugClass":"fenticonazole","explanation":"Imagine your body's cells have a strong, protective wall. Fungi have a similar wall, but Lomexin blocks the production of a key building block, making it harder for the fungus to grow and multiply.","oneSentence":"Lomexin works by inhibiting the growth of fungi through interference with the synthesis of ergosterol, a critical component of fungal cell membranes.","technicalDetail":"Lomexin exerts its antifungal effect by inhibiting the enzyme lanosterol 14α-demethylase, which is essential for the conversion of lanosterol to ergosterol in fungal cells."},"commercial":{},"references":[{"id":1,"url":"https://drugcentral.org/drugcard/1166","fields":["approvals","synonyms","ATC","PK","indications","contraindications","DDIs","targets","patents","FAERS"],"source":"DrugCentral"},{"id":2,"url":"https://clinicaltrials.gov/search?intr=FENTICONAZOLE","fields":["trials"],"source":"ClinicalTrials.gov"},{"id":3,"url":"https://pubmed.ncbi.nlm.nih.gov/?term=FENTICONAZOLE","fields":["publications"],"source":"PubMed/NCBI"}],"_enrichedAt":"2026-03-30T11:16:38.173150","biosimilars":[],"competitors":[{"drugName":"clotrimazole","drugSlug":"clotrimazole","fdaApproval":"1975-02-03","patentExpiry":"May 26, 2042","patentStatus":"Patent protected","relationship":"same-class"},{"drugName":"miconazole","drugSlug":"miconazole","fdaApproval":"1974-01-08","patentStatus":"Unknown","relationship":"same-class"},{"drugName":"econazole","drugSlug":"econazole","fdaApproval":"1982-12-23","patentExpiry":"Aug 8, 2031","patentStatus":"Patent protected","relationship":"same-class"},{"drugName":"thiabendazole","drugSlug":"thiabendazole","fdaApproval":"1967-04-07","patentStatus":"Unknown","relationship":"same-class"},{"drugName":"tioconazole","drugSlug":"tioconazole","fdaApproval":"1983-02-18","genericCount":1,"patentStatus":"Off-patent — generic available","relationship":"same-class"},{"drugName":"ketoconazole","drugSlug":"ketoconazole","fdaApproval":"1981-06-12","genericCount":19,"patentStatus":"Off-patent — generic available","relationship":"same-class"},{"drugName":"sulconazole","drugSlug":"sulconazole","fdaApproval":"1985-08-30","patentStatus":"Unknown","relationship":"same-class"},{"drugName":"oxiconazole","drugSlug":"oxiconazole","fdaApproval":"1988-12-30","genericCount":1,"patentStatus":"Off-patent — generic 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Study of EVEGYN 600 mg/1000 mg/100 mg Vaginal Ovule","status":"COMPLETED","sponsor":"Exeltis Turkey","startDate":"2022-05-09","conditions":["Bioavailability"],"enrollment":18,"completionDate":"2023-03-15"},{"nctId":"NCT06056947","phase":"PHASE3","title":"Evaluation of Efficacy and Safety of Two New Formulations Compared to Gynomax® XL Ovule","status":"COMPLETED","sponsor":"Ege University","startDate":"2020-07-20","conditions":["Trichomonal Vaginitis","Bacterial Vaginosis","Candidal Vulvovaginitis","Mixed Vaginal 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