{"id":"fentiazac","rwe":[{"pmid":"38087933","year":"2024","title":"Copper-mediated [3 + 2] oxidative cyclization of oxime acetate and its utility in the formal synthesis of fentiazac.","finding":"","journal":"Organic & biomolecular chemistry","studyType":"Clinical Study"},{"pmid":"8634349","year":"1995","title":"Analysis of pharmaceutical creams: a useful approach based on solid-phase extraction (SPE) and UV spectrophotometry.","finding":"","journal":"Journal of pharmaceutical and biomedical analysis","studyType":"Clinical Study"},{"pmid":"8229695","year":"1993","title":"Effect of cimetidine on the pharmacokinetics of fentiazac in rats.","finding":"","journal":"Journal of pharmaceutical sciences","studyType":"Clinical Study"},{"pmid":"8447848","year":"1993","title":"Pharmacokinetic study of fentiazac and its main metabolite hydroxyfentiazac in the elderly.","finding":"","journal":"Arzneimittel-Forschung","studyType":"Clinical Study"},{"pmid":"2519359","year":"1989","title":"[Piroxicam and fentiazac do not change the arterial pressure in hypertensives patients undergoing treatment].","finding":"","journal":"Revista medica de Chile","studyType":"Clinical Study"}],"tags":[{"label":"fentiazac","category":"class"},{"label":"Small Molecule","category":"modality"},{"label":"Prostaglandin D2 receptor 2","category":"target"},{"label":"PTGDR2","category":"gene"},{"label":"M01AB10","category":"atc"},{"label":"Active","category":"status"},{"label":"Pain","category":"indication"},{"label":"Analgesics","category":"pharmacology"},{"label":"Analgesics, Non-Narcotic","category":"pharmacology"},{"label":"Anti-Inflammatory Agents","category":"pharmacology"},{"label":"Anti-Inflammatory Agents, Non-Steroidal","category":"pharmacology"},{"label":"Antirheumatic Agents","category":"pharmacology"},{"label":"Peripheral Nervous System Agents","category":"pharmacology"},{"label":"Sensory System Agents","category":"pharmacology"}],"phase":"phase_2","safety":{},"trials":[],"aliases":[],"patents":[],"pricing":[],"allNames":"flogene","offLabel":[],"synonyms":["fentiazac calcium","fentiazac","donorest","flogene"],"timeline":[],"approvals":[],"brandName":"Flogene","ecosystem":[{"indication":"Pain","otherDrugs":[{"name":"acetylsalicylic acid","slug":"acetylsalicylic-acid","company":"Endo Pharms"},{"name":"bromfenac","slug":"bromfenac","company":"Bausch And Lomb Inc"},{"name":"butorphanol","slug":"butorphanol","company":""},{"name":"caffeine","slug":"caffeine","company":"Novartis"}],"globalPrevalence":1500000000}],"mechanism":{"target":"Prostaglandin D2 receptor 2","targets":[{"gene":"PTGDR2","source":"DrugCentral","target":"Prostaglandin D2 receptor 2","protein":"Prostaglandin D2 receptor 2"}],"modality":"Small Molecule","drugClass":"fentiazac","explanation":"Think of prostaglandin D2 like a messenger that tells your brain that you're in pain. When Flogene blocks this messenger, it helps to reduce the pain signal that reaches your brain, providing relief from discomfort.","oneSentence":"Flogene works by blocking the action of prostaglandin D2, a chemical that transmits pain signals to the brain.","technicalDetail":"Flogene acts as a selective antagonist of the Prostaglandin D2 receptor 2 (DP2 receptor), inhibiting the downstream signaling pathways that contribute to pain perception."},"commercial":{},"references":[{"id":1,"url":"https://drugcentral.org/drugcard/1165","fields":["approvals","synonyms","ATC","PK","indications","contraindications","DDIs","targets","patents","FAERS"],"source":"DrugCentral"},{"id":2,"url":"https://pubmed.ncbi.nlm.nih.gov/?term=FENTIAZAC","fields":["publications"],"source":"PubMed/NCBI"}],"_enrichedAt":"2026-03-30T11:16:28.666637","biosimilars":[],"competitors":[{"drugName":"indomethacin","drugSlug":"indomethacin","fdaApproval":"1965-06-10","patentExpiry":"Apr 23, 2030","patentStatus":"Patent protected","relationship":"same-class"},{"drugName":"sulindac","drugSlug":"sulindac","fdaApproval":"1978-09-27","genericCount":7,"patentStatus":"Off-patent — generic available","relationship":"same-class"},{"drugName":"tolmetin","drugSlug":"tolmetin","fdaApproval":"1976-03-24","genericCount":6,"patentStatus":"Off-patent — generic available","relationship":"same-class"},{"drugName":"diclofenac","drugSlug":"diclofenac","fdaApproval":"1988-07-28","patentExpiry":"Apr 23, 2030","patentStatus":"Patent protected","relationship":"same-class"},{"drugName":"etodolac","drugSlug":"etodolac","fdaApproval":"1991-01-31","genericCount":25,"patentStatus":"Off-patent — generic available","relationship":"same-class"},{"drugName":"ketorolac","drugSlug":"ketorolac","fdaApproval":"1989-11-30","patentExpiry":"Nov 24, 2027","patentStatus":"Patent protected","relationship":"same-class"},{"drugName":"aceclofenac","drugSlug":"aceclofenac","fdaApproval":"","relationship":"same-class"}],"genericName":"fentiazac","indications":{"approved":[{"name":"Pain","source":"DrugCentral","snomedId":22253000,"regulator":"FDA","usPrevalence":51600000,"globalPrevalence":1500000000,"prevalenceMethod":"curated","prevalenceSource":"CDC, 2023"}],"offLabel":[],"pipeline":[]},"drugCategory":"active","labelChanges":[],"relatedDrugs":[{"drugId":"indomethacin","brandName":"indomethacin","genericName":"indomethacin","approvalYear":"1965","relationship":"same-class"},{"drugId":"sulindac","brandName":"sulindac","genericName":"sulindac","approvalYear":"1978","relationship":"same-class"},{"drugId":"tolmetin","brandName":"tolmetin","genericName":"tolmetin","approvalYear":"1976","relationship":"same-class"},{"drugId":"diclofenac","brandName":"diclofenac","genericName":"diclofenac","approvalYear":"1988","relationship":"same-class"},{"drugId":"etodolac","brandName":"etodolac","genericName":"etodolac","approvalYear":"1991","relationship":"same-class"},{"drugId":"ketorolac","brandName":"ketorolac","genericName":"ketorolac","approvalYear":"1989","relationship":"same-class"},{"drugId":"aceclofenac","brandName":"aceclofenac","genericName":"aceclofenac","approvalYear":"","relationship":"same-class"}],"trialDetails":[],"genericFilers":[],"latestUpdates":[],"manufacturing":[],"crossReferences":{"NDDF":"005946","UNII":"0YHF6E6NLS","CHEBI":"CHEBI:94523","INN_ID":"3710","UMLSCUI":"C0060201","ChEMBL_ID":"CHEMBL589092","KEGG_DRUG":"D01975","DRUGBANK_ID":"DB13217","PUBCHEM_CID":"28871","SECONDARY_CAS_RN":"85721-24-0","MESH_SUPPLEMENTAL_RECORD_UI":"C006124"},"formularyStatus":[],"_enricherVersion":"v2","developmentCodes":[],"ownershipHistory":[],"publicationCount":49,"therapeuticAreas":["Pain"],"atcClassification":{"source":"DrugCentral","atcCode":"M01AB10","allCodes":["M01AB10","M02AA14"]},"biosimilarFilings":[],"recentPublications":[{"date":"2024 Jan 17","pmid":"38087933","title":"Copper-mediated [3 + 2] oxidative cyclization of oxime acetate and its utility in the formal synthesis of fentiazac.","journal":"Organic & biomolecular chemistry"},{"date":"1995 Oct","pmid":"8634349","title":"Analysis of pharmaceutical creams: a useful approach based on solid-phase extraction (SPE) and UV spectrophotometry.","journal":"Journal of pharmaceutical and biomedical analysis"},{"date":"1993 Sep","pmid":"8229695","title":"Effect of cimetidine on the pharmacokinetics of fentiazac in rats.","journal":"Journal of pharmaceutical sciences"},{"date":"1993 Jan","pmid":"8447848","title":"Pharmacokinetic study of fentiazac and its main metabolite hydroxyfentiazac in the elderly.","journal":"Arzneimittel-Forschung"},{"date":"1989 Oct","pmid":"2519359","title":"[Piroxicam and fentiazac do not change the arterial pressure in hypertensives patients undergoing treatment].","journal":"Revista medica de Chile"}],"companionDiagnostics":[],"genericManufacturerList":[],"status":"active","companyName":"","companyId":"","modality":"Small molecule","firstApprovalDate":"","aiSummary":"Flogene (Fentiazac) is a small molecule drug that targets the Prostaglandin D2 receptor 2. It is classified as a fentiazac and is used to treat pain. The commercial status of Flogene is currently unknown, and it is not clear if it is patented or available as a generic medication. As a fentiazac, Flogene works by interacting with the Prostaglandin D2 receptor 2, which plays a role in pain perception.","enrichmentLevel":3,"visitCount":0,"trialStats":{"total":0,"withResults":0},"verificationStatus":"partial","dataCompleteness":{"mechanism":true,"indications":true,"safety":false,"trials":false,"score":2}}