{"id":"fentanyl-picu-standard","safety":{"commonSideEffects":[{"rate":null,"effect":"Respiratory depression"},{"rate":null,"effect":"Hypotension"},{"rate":null,"effect":"Bradycardia"},{"rate":null,"effect":"Chest wall rigidity"},{"rate":null,"effect":"Tolerance with prolonged use"}]},"_chembl":null,"_dailymed":null,"mechanism":{"_ai_source":"claude-haiku-4.5","explanation":"Fentanyl activates mu-opioid receptors throughout the brain and spinal cord, inhibiting pain signal transmission and producing potent analgesia. In the PICU setting, it is used for both pain management and sedation in critically ill pediatric patients. The drug has a rapid onset and short duration of action, making it suitable for titrated sedation in mechanically ventilated children.","oneSentence":"Fentanyl is a synthetic opioid agonist that binds to mu-opioid receptors in the central nervous system to produce analgesia and sedation.","_ai_confidence":"high"},"_scrapedAt":"2026-03-27T23:46:23.740Z","_scrapedBy":"cloudflare-swarm","_wikipedia":null,"indications":{"approved":[{"name":"Pain management in pediatric intensive care unit (PICU) patients"},{"name":"Sedation in mechanically ventilated pediatric patients"}]},"trialDetails":[{"nctId":"NCT05541029","phase":"NA","title":"Music Listening: A Mechanistic Trial","status":"RECRUITING","sponsor":"University of Pittsburgh","startDate":"2023-03-20","conditions":"Critical Illness","enrollment":171},{"nctId":"NCT07252024","phase":"NA","title":"Nurse-Led BIS-Guided Sedation Protocol in Pediatric Intensive Care","status":"COMPLETED","sponsor":"Dr. Behcet Uz Children's Hospital","startDate":"2024-06-01","conditions":"Nurse's Role, Bispectral Index, Pediatric Sedation","enrollment":88},{"nctId":"NCT05003102","phase":"PHASE4","title":"Dexmedetomidine Cycling and Sleep in the Pediatric ICU","status":"WITHDRAWN","sponsor":"Vanderbilt University Medical Center","startDate":"2023-02-20","conditions":"Critical Illness, Sedation Complication, Delirium","enrollment":""}],"_emaApprovals":[],"_faersSignals":[],"_approvalHistory":[],"publicationCount":2,"rwe":[],"genericFilers":[],"relatedDrugs":[],"labelChanges":[],"biosimilarFilings":[],"pricing":[],"formularyStatus":[],"manufacturing":[],"companionDiagnostics":[],"competitors":[],"timeline":[],"patents":[],"ownershipHistory":[],"trials":[],"biosimilars":[],"latestUpdates":[],"references":[],"tags":[],"ecosystem":[],"genericManufacturerList":[],"offLabel":[],"developmentCodes":[],"aliases":[],"phase":"marketed","status":"active","brandName":"Fentanyl - PICU Standard","genericName":"Fentanyl - PICU Standard","companyName":"Vanderbilt University Medical Center","companyId":"vanderbilt-university-medical-center","modality":"Small molecule","firstApprovalDate":"","aiSummary":"Fentanyl is a synthetic opioid agonist that binds to mu-opioid receptors in the central nervous system to produce analgesia and sedation. Used for Pain management in pediatric intensive care unit (PICU) patients, Sedation in mechanically ventilated pediatric patients.","enrichmentLevel":3,"visitCount":0,"trialStats":{"total":1,"withResults":0},"verificationStatus":"verified","dataCompleteness":{"mechanism":true,"indications":true,"safety":true,"trials":true,"score":4}}