{"id":"fentanyl-f1","safety":{"commonSideEffects":[{"rate":null,"effect":"Respiratory depression"},{"rate":"20–30%","effect":"Nausea and vomiting"},{"rate":"40–50%","effect":"Constipation"},{"rate":"20–30%","effect":"Dizziness and sedation"},{"rate":"10–15%","effect":"Pruritus"},{"rate":null,"effect":"Hypotension"},{"rate":null,"effect":"Dependence and addiction risk"}]},"_chembl":null,"_dailymed":null,"mechanism":{"_ai_source":"claude-haiku-4.5","explanation":"Fentanyl activates mu-opioid receptors throughout the brain and spinal cord, inhibiting pain signal transmission and producing potent analgesic and euphoric effects. It is approximately 50–100 times more potent than morphine on a weight basis. The drug is widely used for acute and chronic pain management, as well as perioperative sedation and anesthesia.","oneSentence":"Fentanyl is a synthetic opioid agonist that binds to mu-opioid receptors in the central nervous system to produce analgesia and sedation.","_ai_confidence":"high"},"_scrapedAt":"2026-03-28T00:39:35.191Z","_scrapedBy":"cloudflare-swarm","_wikipedia":null,"indications":{"approved":[{"name":"Acute postoperative pain"},{"name":"Chronic cancer pain"},{"name":"Chronic non-cancer pain (transdermal formulations)"},{"name":"Perioperative anesthesia and sedation"}]},"trialDetails":[{"nctId":"NCT03894800","phase":"PHASE4","title":"Determination of Analgesic Equipotent Doses of Inhaled Metoxyflurane vs. Intravenous Fentanyl","status":"COMPLETED","sponsor":"Oslo University Hospital","startDate":"2019-04-23","conditions":"Acute Pain, Trauma, Hypovolemia","enrollment":12},{"nctId":"NCT01308320","phase":"PHASE4","title":"Dose-dependent Effect of Fentanyl on Cough Attenuation During Emergence From General Anaesthesia","status":"COMPLETED","sponsor":"Yonsei University","startDate":"2010-02","conditions":"Thyroid Neoplasm","enrollment":42}],"_emaApprovals":[],"_faersSignals":[],"_approvalHistory":[],"publicationCount":40,"rwe":[],"genericFilers":[],"relatedDrugs":[],"labelChanges":[],"biosimilarFilings":[],"pricing":[],"formularyStatus":[],"manufacturing":[],"companionDiagnostics":[],"competitors":[],"timeline":[],"patents":[],"ownershipHistory":[],"trials":[],"biosimilars":[],"latestUpdates":[],"references":[],"tags":[],"ecosystem":[],"genericManufacturerList":[],"offLabel":[],"developmentCodes":[],"aliases":["NaCl (C)"],"phase":"marketed","status":"active","brandName":"Fentanyl (F1)","genericName":"Fentanyl (F1)","companyName":"Oslo University Hospital","companyId":"oslo-university-hospital","modality":"Small molecule","firstApprovalDate":"","aiSummary":"Fentanyl is a synthetic opioid agonist that binds to mu-opioid receptors in the central nervous system to produce analgesia and sedation. Used for Acute postoperative pain, Chronic cancer pain, Chronic non-cancer pain (transdermal formulations).","enrichmentLevel":3,"visitCount":0,"trialStats":{"total":0,"withResults":0},"verificationStatus":"verified","dataCompleteness":{"mechanism":true,"indications":true,"safety":true,"trials":true,"score":4}}