{"id":"fentanyl-ev","safety":{"commonSideEffects":[{"rate":null,"effect":"Respiratory depression"},{"rate":null,"effect":"Hypotension"},{"rate":null,"effect":"Bradycardia"},{"rate":null,"effect":"Nausea and vomiting"},{"rate":null,"effect":"Dizziness"},{"rate":null,"effect":"Constipation"}]},"_chembl":null,"_dailymed":null,"mechanism":{"_ai_source":"claude-haiku-4.5","explanation":"Fentanyl activates mu-opioid receptors throughout the brain and spinal cord, inhibiting pain signal transmission and modulating pain perception. The 'ev' designation likely refers to an intravenous formulation. It is a potent synthetic opioid approximately 50-100 times more potent than morphine.","oneSentence":"Fentanyl is a synthetic opioid agonist that binds to mu-opioid receptors in the central nervous system to produce analgesia and sedation.","_ai_confidence":"high"},"_scrapedAt":"2026-03-27T23:46:21.731Z","_scrapedBy":"cloudflare-swarm","_wikipedia":null,"indications":{"approved":[{"name":"Acute and chronic pain management"},{"name":"Perioperative analgesia and sedation"},{"name":"Palliative care"}]},"trialDetails":[{"nctId":"NCT03080350","phase":"PHASE4","title":"Sublingual Versus Endovenous Fentanyl for the Prehospital Analgesia in Patients With Limb Trauma on the Slope","status":"COMPLETED","sponsor":"Azienda Sanitaria dell'Alto Adige","startDate":"2017-01","conditions":"Acute Pain Due to Trauma","enrollment":108},{"nctId":"NCT03080324","phase":"PHASE4","title":"Sublingual Versus Endovenous Fentanyl for Pain Treatment in Trauma Patients in the Emergency Room","status":"COMPLETED","sponsor":"Azienda Sanitaria dell'Alto Adige","startDate":"2016-12-01","conditions":"Acute Pain Due to Trauma","enrollment":108},{"nctId":"NCT00571636","phase":"PHASE3","title":"Continuous Infusion of Fentanyl in Preterm on MV","status":"COMPLETED","sponsor":"IRCCS Azienda Ospedaliero-Universitaria di Bologna","startDate":"2007-12","conditions":"Pain, Infant, Premature, Diseases, Respiration; Insufficient or Poor, Newborn","enrollment":128}],"_emaApprovals":[],"_faersSignals":[],"_approvalHistory":[],"publicationCount":16,"rwe":[],"genericFilers":[],"relatedDrugs":[],"labelChanges":[],"biosimilarFilings":[],"pricing":[],"formularyStatus":[],"manufacturing":[],"companionDiagnostics":[],"competitors":[],"timeline":[],"patents":[],"ownershipHistory":[],"trials":[],"biosimilars":[],"latestUpdates":[],"references":[],"tags":[],"ecosystem":[],"genericManufacturerList":[],"offLabel":[],"developmentCodes":[],"aliases":["Fentanest"],"phase":"marketed","status":"active","brandName":"Fentanyl ev","genericName":"Fentanyl ev","companyName":"Azienda Sanitaria dell'Alto Adige","companyId":"azienda-sanitaria-dell-alto-adige","modality":"Small molecule","firstApprovalDate":"","aiSummary":"Fentanyl is a synthetic opioid agonist that binds to mu-opioid receptors in the central nervous system to produce analgesia and sedation. Used for Acute and chronic pain management, Perioperative analgesia and sedation, Palliative care.","enrichmentLevel":3,"visitCount":0,"trialStats":{"total":1,"withResults":0},"verificationStatus":"verified","dataCompleteness":{"mechanism":true,"indications":true,"safety":true,"trials":true,"score":4}}