{"id":"fentanyl-and-dexmedetomindine","brandName":"fentanyl and dexmedetomindine","genericName":"fentanyl and dexmedetomindine","companyId":"the-affiliated-hospital-of-qingdao-university","companyName":"The Affiliated Hospital of Qingdao University","phase":"marketed","status":"active","modality":"Small molecule","aliases":[],"developmentCodes":[],"firstApprovalDate":null,"firstApprovalCountry":null,"aiSummary":"The combination of fentanyl and dexmedetomidine is under investigation for sedation and analgesia in mechanically ventilated patients. This regimen aims to improve patient comfort and reduce adverse events compared to standard care.","enrichmentLevel":3,"visitCount":0,"mechanism":{"_ai_source":"claude-haiku-4.5","explanation":"Fentanyl acts as a potent mu opioid receptor agonist, blocking pain signal transmission and producing analgesia and sedation. Dexmedetomidine selectively binds alpha-2 adrenergic receptors in the central nervous system, producing sedation, analgesia, and anxiolysis while preserving airway reflexes better than opioids alone. The combination provides synergistic analgesic and sedative effects with potentially reduced opioid requirements.","oneSentence":"Fentanyl is an opioid agonist that binds mu opioid receptors for analgesia and sedation, while dexmedetomidine is an alpha-2 adrenergic agonist that provides additional sedation and analgesia with reduced respiratory depression.","_ai_confidence":"medium"},"administration":{},"safety":{"commonSideEffects":[{"rate":null,"effect":"Respiratory depression"},{"rate":null,"effect":"Hypotension"},{"rate":null,"effect":"Bradycardia"},{"rate":null,"effect":"Sedation"},{"rate":null,"effect":"Dizziness"}]},"trials":[],"indications":{"approved":[{"name":"Perioperative analgesia and sedation"},{"name":"Procedural sedation"}]},"commercial":null,"patents":[],"timeline":[],"rwe":[],"competitors":[],"ownershipHistory":[],"trialDetails":[{"nctId":"NCT05024799","phase":"PHASE4","title":"Effect of Different Sedation and Analgesia Strategies on Patients With Mechanical Ventilation","status":"UNKNOWN","sponsor":"The Affiliated Hospital of Qingdao University","startDate":"2022-01","conditions":["Respiratory Insufficiency"],"enrollment":300,"completionDate":"2024-12"}],"genericFilers":[],"biosimilarFilings":[],"pricing":[],"formularyStatus":[],"manufacturing":[],"companionDiagnostics":[],"labelChanges":[],"nice":null,"revenue":null,"trialStats":{"total":0,"withResults":0},"verificationStatus":"verified","dataCompleteness":{"mechanism":true,"indications":true,"safety":true,"trials":true,"score":4}}