{"id":"fenpiverinium","rwe":[{"pmid":"33606526","year":"2021","title":"Identification of Novel High-Affinity Substrates of OCT1 Using Machine Learning-Guided Virtual Screening and Experimental Validation.","finding":"","journal":"Journal of medicinal chemistry","studyType":"Clinical Study"},{"pmid":"25255449","year":"2015","title":"Separation and determination of impurities in paracetamol, codeine and pitophenone in the presence of fenpiverinium in combined suppository dosage form.","finding":"","journal":"Journal of pharmaceutical and biomedical analysis","studyType":"Clinical Study"},{"pmid":"10645700","year":"1999","title":"Double blind, randomised, parallel, prospective, comparative, clinical evaluation of a combination of antispasmodic analgesic Diclofenac + Pitofenone + Fenpiverinium (Manyana vs Analgin + Pitofenone + Fenpiverinium (Baralgan) in biliary, ureteric and intestinal colic.","finding":"","journal":"Journal of the Indian Medical Association","studyType":"Clinical Study"},{"pmid":"10638099","year":"1999","title":"Open labelled evaluation of injection Manyana (a combination of diclofenac + pitofenone + fenpiverinium) in ureteric, biliary and intestinal spasm--a preliminary report.","finding":"","journal":"Journal of the Indian Medical Association","studyType":"Clinical Study"},{"pmid":"10549201","year":"1999","title":"Double blind, randomised, parallel, prospective, comparative, clinical evaluation of a combination of antispasmodic analgesic Diclofenac + Pitofenone + Fenpiverinium (Manyana) vs Analgin + Pitofenone + Fenpiverinium (Baralgan) in biliary, ureteric and intestinal colic.","finding":"","journal":"Journal of the Indian Medical Association","studyType":"Clinical Study"}],"tags":[{"label":"fenpiverinium","category":"class"},{"label":"Small Molecule","category":"modality"},{"label":"A03AB21","category":"atc"},{"label":"Active","category":"status"}],"phase":"phase_2","safety":{},"trials":[],"aliases":[],"patents":[],"pricing":[],"allNames":["fenpiverinium","fenpiverinium bromide"],"offLabel":[],"synonyms":["fenpiverinium","fenpiverinium bromide"],"timeline":[],"approvals":[],"ecosystem":[],"mechanism":{"modality":"Small Molecule","drugClass":"fenpiverinium","explanation":"Unfortunately, the exact way fenpiverinium works is not well understood, but it is thought to affect the body's response to certain stimuli. This can lead to changes in how the body functions, which can be beneficial for treating certain conditions. However, more research is needed to fully understand its mechanism of action.","oneSentence":"Fenpiverinium works by interacting with a specific target in the body to produce a therapeutic effect.","technicalDetail":"Fenpiverinium is a small molecule that binds to a specific target, likely a receptor or enzyme, to produce its therapeutic effect. The exact nature of this interaction is unknown, but it is thought to involve a change in the conformation of the target protein, leading to a cascade of downstream effects."},"commercial":{},"references":[{"id":1,"url":"https://drugcentral.org/drugcard/1160","fields":["approvals","synonyms","ATC","PK","indications","contraindications","DDIs","targets","patents","FAERS"],"source":"DrugCentral"},{"id":2,"url":"https://clinicaltrials.gov/search?intr=FENPIVERINIUM","fields":["trials"],"source":"ClinicalTrials.gov"},{"id":3,"url":"https://pubmed.ncbi.nlm.nih.gov/?term=FENPIVERINIUM","fields":["publications"],"source":"PubMed/NCBI"}],"_enrichedAt":"2026-03-30T11:15:43.186941","biosimilars":[],"competitors":[{"drugName":"glycopyrronium bromide","drugSlug":"glycopyrronium-bromide","fdaApproval":"1961-08-11","relationship":"same-class"},{"drugName":"oxyphenonium","drugSlug":"oxyphenonium","fdaApproval":"","patentStatus":"Unknown","relationship":"same-class"},{"drugName":"propantheline","drugSlug":"propantheline","fdaApproval":"1953-04-02","genericCount":10,"patentStatus":"Off-patent — generic available","relationship":"same-class"},{"drugName":"methanthelinium","drugSlug":"methanthelinium","fdaApproval":"1951-07-03","relationship":"same-class"},{"drugName":"tridihexethyl","drugSlug":"tridihexethyl","fdaApproval":"1954-09-15","patentStatus":"Unknown","relationship":"same-class"},{"drugName":"isopropamide","drugSlug":"isopropamide","fdaApproval":"1957-10-09","patentStatus":"Unknown","relationship":"same-class"},{"drugName":"hexocyclium","drugSlug":"hexocyclium","fdaApproval":"","patentStatus":"Unknown","relationship":"same-class"},{"drugName":"mepenzolate","drugSlug":"mepenzolate","fdaApproval":"1956-11-14","patentStatus":"Unknown","relationship":"same-class"},{"drugName":"diphemanil","drugSlug":"diphemanil","fdaApproval":"1976-05-17","patentStatus":"Unknown","relationship":"same-class"}],"genericName":"fenpiverinium","indications":{"approved":[],"offLabel":[],"pipeline":[]},"drugCategory":"active","labelChanges":[],"relatedDrugs":[{"drugId":"glycopyrronium-bromide","brandName":"glycopyrronium bromide","genericName":"glycopyrronium bromide","approvalYear":"1961","relationship":"same-class"},{"drugId":"oxyphenonium","brandName":"oxyphenonium","genericName":"oxyphenonium","approvalYear":"","relationship":"same-class"},{"drugId":"propantheline","brandName":"propantheline","genericName":"propantheline","approvalYear":"1953","relationship":"same-class"},{"drugId":"methanthelinium","brandName":"methanthelinium","genericName":"methanthelinium","approvalYear":"1951","relationship":"same-class"},{"drugId":"tridihexethyl","brandName":"tridihexethyl","genericName":"tridihexethyl","approvalYear":"1954","relationship":"same-class"},{"drugId":"isopropamide","brandName":"isopropamide","genericName":"isopropamide","approvalYear":"1957","relationship":"same-class"},{"drugId":"hexocyclium","brandName":"hexocyclium","genericName":"hexocyclium","approvalYear":"","relationship":"same-class"},{"drugId":"mepenzolate","brandName":"mepenzolate","genericName":"mepenzolate","approvalYear":"1956","relationship":"same-class"},{"drugId":"diphemanil","brandName":"diphemanil","genericName":"diphemanil","approvalYear":"1976","relationship":"same-class"}],"trialDetails":[{"nctId":"NCT05607641","phase":"PHASE2,PHASE3","title":"Efficacy and Safety Study of Ketorolac / Pitofenone / Fenpiverinium for the Treatment of Patients With Pain After Surgical Abdominal and Pelvic Operations","status":"COMPLETED","sponsor":"Darnitsa Pharmaceutical Company","startDate":"2021-07-07","conditions":["Postsurgical Pain"],"enrollment":424,"completionDate":"2022-05-13"}],"genericFilers":[],"latestUpdates":[],"manufacturing":[],"crossReferences":{"NDDF":"005918","UNII":"KP2L8LC73B","CHEBI":"CHEBI:94773","INN_ID":"3050","UMLSCUI":"C0060190","ChEMBL_ID":"CHEMBL1884833","KEGG_DRUG":"D07070","DRUGBANK_ID":"DB13759","PUBCHEM_CID":"71490","SECONDARY_CAS_RN":"125-60-0","MESH_SUPPLEMENTAL_RECORD_UI":"C005711"},"formularyStatus":[],"_enricherVersion":"v2","developmentCodes":[],"ownershipHistory":[],"publicationCount":9,"therapeuticAreas":["Other"],"atcClassification":{"source":"DrugCentral","atcCode":"A03AB21","allCodes":["A03AB21"]},"biosimilarFilings":[],"recentPublications":[{"date":"2021 Mar 11","pmid":"33606526","title":"Identification of Novel High-Affinity Substrates of OCT1 Using Machine Learning-Guided Virtual Screening and Experimental Validation.","journal":"Journal of medicinal chemistry"},{"date":"2015 Jan","pmid":"25255449","title":"Separation and determination of impurities in paracetamol, codeine and pitophenone in the presence of fenpiverinium in combined suppository dosage form.","journal":"Journal of pharmaceutical and biomedical analysis"},{"date":"1999 Jun","pmid":"10645700","title":"Double blind, randomised, parallel, prospective, comparative, clinical evaluation of a combination of antispasmodic analgesic Diclofenac + Pitofenone + Fenpiverinium (Manyana vs Analgin + Pitofenone + Fenpiverinium (Baralgan) in biliary, ureteric and intestinal colic.","journal":"Journal of the Indian Medical Association"},{"date":"1999 Sep","pmid":"10638099","title":"Open labelled evaluation of injection Manyana (a combination of diclofenac + pitofenone + fenpiverinium) in ureteric, biliary and intestinal spasm--a preliminary report.","journal":"Journal of the Indian Medical Association"},{"date":"1999 Feb","pmid":"10549201","title":"Double blind, randomised, parallel, prospective, comparative, clinical evaluation of a combination of antispasmodic analgesic Diclofenac + Pitofenone + Fenpiverinium (Manyana) vs Analgin + Pitofenone + Fenpiverinium (Baralgan) in biliary, ureteric and intestinal colic.","journal":"Journal of the Indian Medical Association"}],"companionDiagnostics":[],"genericManufacturerList":[],"status":"active","brandName":"FENPIVERINIUM","companyName":"","companyId":"","modality":"Small molecule","firstApprovalDate":"","aiSummary":"Fenpiverinium is a small molecule drug in the fenpiverinium class, but its target and exact mechanism of action are unknown. It is not clear if it has been approved by the FDA or if it is patented or off-patent. There is limited information available on its pharmacokinetic properties, such as half-life and bioavailability. Further research is needed to understand its clinical use and safety profile. As a result, it is not possible to provide a comprehensive summary of its commercial status or key safety considerations.","enrichmentLevel":3,"visitCount":1,"trialStats":{"total":0,"withResults":0},"verificationStatus":"partial","dataCompleteness":{"mechanism":true,"indications":false,"safety":false,"trials":true,"score":2}}