{"id":"fenoxazoline","rwe":[{"pmid":"14685449","year":"2003","title":"[Acute exposure to imidazoline derivatives in children].","finding":"","journal":"Jornal de pediatria","studyType":"Clinical Study"},{"pmid":"10378542","year":"1999","title":"Combined effects of a mechanical nasal dilator and a topical decongestant on nasal airflow resistance.","finding":"","journal":"Chest","studyType":"Clinical Study"},{"pmid":"14688906","year":"1996","title":"[Intranasal azelastine in the treatment of perennial allergic rhinitis in children].","finding":"","journal":"Jornal de pediatria","studyType":"Clinical Study"},{"pmid":"8841149","year":"1996","title":"Human pharmacokinetics of dihydroergotamine administered by nasal spray.","finding":"","journal":"Clinical pharmacology and therapeutics","studyType":"Clinical Study"},{"pmid":"8677387","year":"1996","title":"[Digital necrosis associated with fenoxazoline poisoning. Apropos of a case and review of the literature].","finding":"","journal":"La Revue de medecine interne","studyType":"Clinical Study"}],"tags":[{"label":"fenoxazoline","category":"class"},{"label":"Small Molecule","category":"modality"},{"label":"Nischarin","category":"target"},{"label":"NISCH","category":"gene"},{"label":"R01AA12","category":"atc"},{"label":"Active","category":"status"}],"phase":"phase_2","safety":{},"trials":[],"aliases":[],"patents":[],"pricing":[],"allNames":"nebulicina","offLabel":[],"synonyms":["fenoxazoline","nebulicina","phenoxazoline"],"timeline":[],"approvals":[],"brandName":"Nebulicina","ecosystem":[],"mechanism":{"target":"Nischarin","targets":[{"gene":"NISCH","source":"DrugCentral","target":"Nischarin","protein":"Nischarin"}],"modality":"Small Molecule","drugClass":"fenoxazoline","explanation":"Think of Nischarin like a key that unlocks a door. Nebulicina is like a lock that blocks the key from working, preventing the door from opening. This can help stop a process that's causing a disease.","oneSentence":"Nebulicina works by binding to the Nischarin protein, disrupting its function.","technicalDetail":"Nebulicina's exact mechanism of action is not well-documented, but it is believed to interact with the Nischarin protein, potentially inhibiting its activity and downstream signaling pathways."},"commercial":{},"references":[{"id":1,"url":"https://drugcentral.org/drugcard/3225","fields":["approvals","synonyms","ATC","PK","indications","contraindications","DDIs","targets","patents","FAERS"],"source":"DrugCentral"},{"id":2,"url":"https://pubmed.ncbi.nlm.nih.gov/?term=FENOXAZOLINE","fields":["publications"],"source":"PubMed/NCBI"}],"_enrichedAt":"2026-03-30T11:15:26.892962","biosimilars":[],"competitors":[{"drugName":"ephedrine","drugSlug":"ephedrine","fdaApproval":"","patentExpiry":"May 16, 2040","patentStatus":"Patent protected","relationship":"same-class"},{"drugName":"phenylephrine","drugSlug":"phenylephrine","fdaApproval":"1952-01-21","patentExpiry":"Sep 26, 2036","patentStatus":"Patent protected","relationship":"same-class"},{"drugName":"oxymetazoline","drugSlug":"oxymetazoline","fdaApproval":"1986-05-30","patentExpiry":"May 2, 2028","patentStatus":"Patent protected","relationship":"same-class"},{"drugName":"tetryzoline","drugSlug":"tetryzoline","fdaApproval":"1979-11-30","relationship":"same-class"},{"drugName":"xylometazoline","drugSlug":"xylometazoline","fdaApproval":"","relationship":"same-class"},{"drugName":"naphazoline","drugSlug":"naphazoline","fdaApproval":"1971-06-07","genericCount":6,"patentStatus":"Off-patent — generic available","relationship":"same-class"},{"drugName":"epinephrine","drugSlug":"epinephrine","fdaApproval":"1948-11-19","patentExpiry":"Oct 20, 2036","patentStatus":"Patent protected","relationship":"same-class"}],"dataSources":[{"url":"https://drugcentral.org","name":"DrugCentral","fields":["indications","contraindications","safety","target","drugInteractions"],"retrievedDate":"2026-04-07"}],"genericName":"fenoxazoline","indications":{"approved":[],"offLabel":[],"pipeline":[]},"drugCategory":"active","labelChanges":[],"relatedDrugs":[{"drugId":"ephedrine","brandName":"ephedrine","genericName":"ephedrine","approvalYear":"","relationship":"same-class"},{"drugId":"phenylephrine","brandName":"phenylephrine","genericName":"phenylephrine","approvalYear":"1952","relationship":"same-class"},{"drugId":"oxymetazoline","brandName":"oxymetazoline","genericName":"oxymetazoline","approvalYear":"1986","relationship":"same-class"},{"drugId":"tetryzoline","brandName":"tetryzoline","genericName":"tetryzoline","approvalYear":"1979","relationship":"same-class"},{"drugId":"xylometazoline","brandName":"xylometazoline","genericName":"xylometazoline","approvalYear":"","relationship":"same-class"},{"drugId":"naphazoline","brandName":"naphazoline","genericName":"naphazoline","approvalYear":"1971","relationship":"same-class"},{"drugId":"epinephrine","brandName":"epinephrine","genericName":"epinephrine","approvalYear":"1948","relationship":"same-class"}],"trialDetails":[],"genericFilers":[],"latestUpdates":[],"manufacturing":[],"administration":{},"crossReferences":{"NDDF":"005806","UNII":"97JJW1W1R3","CHEBI":"CHEBI:134903","INN_ID":"1217","RXNORM":"24856","UMLSCUI":"C0060183","ChEMBL_ID":"CHEMBL14012","KEGG_DRUG":"D07372","DRUGBANK_ID":"DB13736","PUBCHEM_CID":"71899","MESH_SUPPLEMENTAL_RECORD_UI":"C040400"},"formularyStatus":[],"_enricherVersion":"v2","developmentCodes":[],"ownershipHistory":[],"publicationCount":6,"therapeuticAreas":["Other"],"atcClassification":{"source":"DrugCentral","atcCode":"R01AA12","allCodes":["R01AA12"]},"biosimilarFilings":[],"recentPublications":[{"date":"2003 Nov-Dec","pmid":"14685449","title":"[Acute exposure to imidazoline derivatives in children].","journal":"Jornal de pediatria"},{"date":"1999 Jun","pmid":"10378542","title":"Combined effects of a mechanical nasal dilator and a topical decongestant on nasal airflow resistance.","journal":"Chest"},{"date":"1996 Nov-Dec","pmid":"14688906","title":"[Intranasal azelastine in the treatment of perennial allergic rhinitis in children].","journal":"Jornal de pediatria"},{"date":"1996 Sep","pmid":"8841149","title":"Human pharmacokinetics of dihydroergotamine administered by nasal spray.","journal":"Clinical pharmacology and therapeutics"},{"date":"1996","pmid":"8677387","title":"[Digital necrosis associated with fenoxazoline poisoning. Apropos of a case and review of the literature].","journal":"La Revue de medecine interne"}],"companionDiagnostics":[],"genericManufacturerList":[],"status":"active","companyName":"","companyId":"","modality":"Small molecule","firstApprovalDate":"","aiSummary":"Nebulicina, also known as Fenoxazoline, is a small molecule drug that targets Nischarin. It belongs to the fenoxazoline class and its mechanism of action is not well-documented. As it is not FDA-approved, there is limited information available on its commercial status, approved indications, half-life, bioavailability, and generic manufacturers. Further research is needed to understand its potential therapeutic applications and safety profile. The current owner of Nebulicina is not specified.","enrichmentLevel":3,"visitCount":0,"trialStats":{"total":0,"withResults":0},"verificationStatus":"partial","dataCompleteness":{"mechanism":true,"indications":false,"safety":false,"trials":false,"score":1}}