{"id":"fendiline","rwe":[],"tags":[{"label":"fendiline","category":"class"},{"label":"Small Molecule","category":"modality"},{"label":"Extracellular calcium-sensing receptor","category":"target"},{"label":"CASR","category":"gene"},{"label":"HTR2B","category":"gene"},{"label":"SMPD1","category":"gene"},{"label":"C08EA01","category":"atc"},{"label":"Active","category":"status"},{"label":"Ischemic heart disease","category":"indication"},{"label":"Calcium Channel Blockers","category":"pharmacology"},{"label":"Calcium-Regulating Hormones and Agents","category":"pharmacology"},{"label":"Cardiovascular Agents","category":"pharmacology"},{"label":"Membrane Transport Modulators","category":"pharmacology"}],"phase":"phase_2","safety":{},"trials":[],"aliases":[],"patents":[],"pricing":[],"allNames":"fendilin","offLabel":[],"synonyms":["fendiline hydrochloride","fendiline","fendilin","(+/-)-Fendiline","phendilin","fendiline HCl"],"timeline":[],"approvals":[],"brandName":"Fendilin","ecosystem":[{"indication":"Ischemic heart disease","otherDrugs":[],"globalPrevalence":38300000}],"mechanism":{"target":"Extracellular calcium-sensing receptor","targets":[{"gene":"CASR","source":"DrugCentral","target":"Extracellular calcium-sensing receptor","protein":"Extracellular calcium-sensing receptor"},{"gene":"HTR2B","source":"DrugCentral","target":"5-hydroxytryptamine receptor 2B","protein":"5-hydroxytryptamine receptor 2B"},{"gene":"SMPD1","source":"DrugCentral","target":"Sphingomyelin phosphodiesterase","protein":"Sphingomyelin phosphodiesterase"}],"modality":"Small Molecule","drugClass":"fendiline","explanation":"Think of it like a thermostat in your home. The extracellular calcium-sensing receptor acts like a thermostat, helping to keep calcium levels in the body stable. Fendiline helps this thermostat work better, which can help treat conditions like ischemic heart disease.","oneSentence":"Fendiline works by binding to the extracellular calcium-sensing receptor, which helps regulate calcium levels in the body.","technicalDetail":"Fendiline acts as a positive allosteric modulator of the extracellular calcium-sensing receptor, increasing its sensitivity to calcium ions and thereby modulating calcium homeostasis."},"commercial":{},"references":[{"id":1,"url":"https://drugcentral.org/drugcard/1148","fields":["approvals","synonyms","ATC","PK","indications","contraindications","DDIs","targets","patents","FAERS"],"source":"DrugCentral"},{"id":2,"url":"https://clinicaltrials.gov/search?intr=FENDILINE","fields":["trials"],"source":"ClinicalTrials.gov"},{"id":3,"url":"https://pubmed.ncbi.nlm.nih.gov/?term=FENDILINE","fields":["publications"],"source":"PubMed/NCBI"}],"_enrichedAt":"2026-03-30T14:56:25.589545","biosimilars":[],"competitors":[{"drugName":"bepridil","drugSlug":"bepridil","fdaApproval":"1990-12-28","patentStatus":"Unknown","relationship":"same-class"}],"genericName":"fendiline","indications":{"approved":[{"name":"Ischemic heart disease","source":"DrugCentral","snomedId":414545008,"regulator":"FDA","globalPrevalence":38300000,"prevalenceMethod":"ai-extracted","prevalenceSource":"BMJ, 2016 (PMID:27510511)"}],"offLabel":[],"pipeline":[]},"drugCategory":"active","labelChanges":[],"relatedDrugs":[{"drugId":"bepridil","brandName":"bepridil","genericName":"bepridil","approvalYear":"1990","relationship":"same-class"}],"trialDetails":[{"nctId":"NCT07262710","phase":"","title":"Association of Angiotensin-Converting Enzyme Inhibitors and Angiotensin Receptor Blockers With Post-Stroke Pneumonia: A Real-World Retrospective Cohort Study","status":"NOT_YET_RECRUITING","sponsor":"First Teaching Hospital of Tianjin University of Traditional Chinese Medicine","startDate":"2025-12-01","conditions":["Post-stroke Pneumonia"],"enrollment":13656,"completionDate":"2026-08-19"}],"genericFilers":[],"latestUpdates":[],"manufacturing":[],"crossReferences":{"NUI":"N0000166521","NDDF":"006773","UNII":"S253D559A8","CHEBI":"CHEBI:94434","INN_ID":"2924","RXNORM":"236767","UMLSCUI":"C0015824","ChEMBL_ID":"CHEMBL254832","KEGG_DRUG":"D07185","DRUGBANK_ID":"DB08980","PUBCHEM_CID":"3336","SECONDARY_CAS_RN":"13636-18-5","MESH_DESCRIPTOR_UI":"D005275"},"formularyStatus":[],"_enricherVersion":"v2","developmentCodes":[],"ownershipHistory":[],"publicationCount":166,"therapeuticAreas":["Cardiovascular"],"atcClassification":{"source":"DrugCentral","atcCode":"C08EA01","allCodes":["C08EA01"]},"biosimilarFilings":[],"recentPublications":[],"companionDiagnostics":[],"genericManufacturerList":[],"status":"active","companyName":"","companyId":"","modality":"Small molecule","firstApprovalDate":"","aiSummary":"Fendilin is a small molecule with the synonyms Fendilina, Fendiline, and Fendiline. It has been studied in relation to post-stroke pneumonia in a real-world retrospective cohort study, comparing its effects to angiotensin converting enzyme inhibitors, Calcium Channel Blockers, and Angiotensin Receptor Blockers.","enrichmentLevel":3,"visitCount":1,"trialStats":{"total":0,"withResults":0},"verificationStatus":"verified","dataCompleteness":{"mechanism":true,"indications":true,"safety":false,"trials":true,"score":3}}