{"id":"fencamfamin","rwe":[{"pmid":"2859077","year":"1985","title":"Amphetamine, mazindol, and fencamfamin in narcolepsy.","finding":"","journal":"British medical journal (Clinical research ed.)","studyType":"Clinical Study"},{"pmid":"5348439","year":"1969","title":"Interactions of oestrogenic and progestational steroids with dexamphetamine and fencamfamin in mice.","finding":"","journal":"British journal of pharmacology","studyType":"Clinical Study"},{"pmid":"4239211","year":"1968","title":"[Reserpine-parkinsonoid syndrome in the chimpanzee and its treatment with fencamfamin].","finding":"","journal":"Naunyn-Schmiedebergs Archiv fur experimentelle Pathologie und Pharmakologie","studyType":"Clinical Study"},{"pmid":"5943119","year":"1966","title":"An EEG study of 2-phynyl-3-ethylaminobicyclo-(2,2,1)-hepatane HCl (fencamfamin hydrochloride).","finding":"","journal":"Life sciences","studyType":"Clinical Study"},{"pmid":"14218622","year":"1964","title":"FENCAMFAMIN VERSUS PLACEBO IN DEPRESSED PATIENTS.","finding":"","journal":"The Journal of new drugs","studyType":"Clinical Study"}],"tags":[{"label":"fencamfamin","category":"class"},{"label":"Small Molecule","category":"modality"},{"label":"N06BA06","category":"atc"},{"label":"Active","category":"status"},{"label":"Antipsychotic Agents","category":"pharmacology"},{"label":"Central Nervous System Agents","category":"pharmacology"},{"label":"Central Nervous System Depressants","category":"pharmacology"},{"label":"Central Nervous System Stimulants","category":"pharmacology"},{"label":"Psychotropic Drugs","category":"pharmacology"},{"label":"Tranquilizing Agents","category":"pharmacology"}],"phase":"phase_2","safety":{},"trials":[],"aliases":[],"patents":[],"pricing":[],"allNames":"reactivan","offLabel":[],"synonyms":["fencamfamine hydrochloride","fencamfamine HCl","reactivan","fencamfamin","fencamfamine","fencamfaminum","phencamphamine"],"timeline":[],"approvals":[],"brandName":"Reactivan","ecosystem":[],"mechanism":{"modality":"Small Molecule","drugClass":"fencamfamin","explanation":"This means that it may help improve mood and cognitive function by enhancing communication between brain cells. However, the exact details of how it achieves this are not well understood.","oneSentence":"Reactivan is thought to work by increasing the release of certain neurotransmitters in the brain.","technicalDetail":"Fencamfamin is believed to act as a dopamine and norepinephrine reuptake inhibitor, increasing the concentration of these neurotransmitters in the synaptic cleft and enhancing their effects on the brain."},"_wikipedia":{"url":"https://en.wikipedia.org/wiki/Fencamfamin","title":"Fencamfamin","extract":"Fencamfamin (INN), also known as fencamfamine or by the brand names Glucoenergan and Reactivan, is a stimulant which was developed by Merck in the 1960s."},"commercial":{},"references":[{"id":1,"url":"https://drugcentral.org/drugcard/1146","fields":["approvals","synonyms","ATC","PK","indications","contraindications","DDIs","targets","patents","FAERS"],"source":"DrugCentral"},{"id":2,"url":"https://pubmed.ncbi.nlm.nih.gov/?term=FENCAMFAMIN","fields":["publications"],"source":"PubMed/NCBI"},{"id":3,"url":"https://en.wikipedia.org/wiki/Fencamfamin","fields":["history","overview"],"source":"Wikipedia"}],"_enrichedAt":"2026-03-30T11:14:41.452370","biosimilars":[],"competitors":[{"drugName":"amfetamine","drugSlug":"amfetamine","fdaApproval":"1955-09-09","relationship":"same-class"},{"drugName":"dexamfetamine","drugSlug":"dexamfetamine","fdaApproval":"1955-09-09","relationship":"same-class"},{"drugName":"methamphetamine","drugSlug":"methamphetamine","fdaApproval":"1943-12-31","genericCount":5,"patentStatus":"Off-patent — generic available","relationship":"same-class"},{"drugName":"methylphenidate","drugSlug":"methylphenidate","fdaApproval":"1955-12-05","patentExpiry":"Jun 5, 2026","patentStatus":"Patent protected","relationship":"same-class"},{"drugName":"pemoline","drugSlug":"pemoline","fdaApproval":"1975-01-27","genericCount":6,"patentStatus":"Off-patent — generic available","relationship":"same-class"},{"drugName":"modafinil","drugSlug":"modafinil","fdaApproval":"1998-12-24","genericCount":9,"patentStatus":"Off-patent — generic available","relationship":"same-class"},{"drugName":"atomoxetine","drugSlug":"atomoxetine","fdaApproval":"2002-11-26","genericCount":8,"patentStatus":"Off-patent — generic available","relationship":"same-class"},{"drugName":"dexmethylphenidate","drugSlug":"dexmethylphenidate","fdaApproval":"2001-11-13","genericCount":19,"patentStatus":"Off-patent — generic available","relationship":"same-class"},{"drugName":"lisdexamfetamine","drugSlug":"lisdexamfetamine","fdaApproval":"2007-02-23","patentExpiry":"Aug 30, 2040","patentStatus":"Patent protected","relationship":"same-class"},{"drugName":"armodafinil","drugSlug":"armodafinil","fdaApproval":"2007-06-05","genericCount":6,"patentStatus":"Off-patent — generic available","relationship":"same-class"},{"drugName":"solriamfetol","drugSlug":"solriamfetol","fdaApproval":"2019-03-20","patentExpiry":"Sep 5, 2037","patentStatus":"Patent protected","relationship":"same-class"},{"drugName":"serdexmethylphenidate","drugSlug":"serdexmethylphenidate","fdaApproval":"2021-03-02","relationship":"same-class"}],"genericName":"fencamfamin","indications":{"approved":[],"offLabel":[],"pipeline":[]},"drugCategory":"active","labelChanges":[],"relatedDrugs":[{"drugId":"amfetamine","brandName":"amfetamine","genericName":"amfetamine","approvalYear":"1955","relationship":"same-class"},{"drugId":"dexamfetamine","brandName":"dexamfetamine","genericName":"dexamfetamine","approvalYear":"1955","relationship":"same-class"},{"drugId":"methamphetamine","brandName":"methamphetamine","genericName":"methamphetamine","approvalYear":"1943","relationship":"same-class"},{"drugId":"methylphenidate","brandName":"methylphenidate","genericName":"methylphenidate","approvalYear":"1955","relationship":"same-class"},{"drugId":"pemoline","brandName":"pemoline","genericName":"pemoline","approvalYear":"1975","relationship":"same-class"},{"drugId":"modafinil","brandName":"modafinil","genericName":"modafinil","approvalYear":"1998","relationship":"same-class"},{"drugId":"atomoxetine","brandName":"atomoxetine","genericName":"atomoxetine","approvalYear":"2002","relationship":"same-class"},{"drugId":"dexmethylphenidate","brandName":"dexmethylphenidate","genericName":"dexmethylphenidate","approvalYear":"2001","relationship":"same-class"},{"drugId":"lisdexamfetamine","brandName":"lisdexamfetamine","genericName":"lisdexamfetamine","approvalYear":"2007","relationship":"same-class"},{"drugId":"armodafinil","brandName":"armodafinil","genericName":"armodafinil","approvalYear":"2007","relationship":"same-class"}],"trialDetails":[],"genericFilers":[],"latestUpdates":[],"manufacturing":[],"crossReferences":{"NDDF":"008077","UNII":"NME1I5IGBK","CHEBI":"CHEBI:134895","INN_ID":"1286","UMLSCUI":"C0060157","ChEMBL_ID":"CHEMBL7010","KEGG_DRUG":"D07343","DRUGBANK_ID":"DB01463","PUBCHEM_CID":"14584","SNOMEDCT_US":"96249005","MESH_SUPPLEMENTAL_RECORD_UI":"C020900"},"formularyStatus":[],"_enricherVersion":"v2","developmentCodes":[],"ownershipHistory":[],"publicationCount":6,"therapeuticAreas":["Neuroscience"],"atcClassification":{"source":"DrugCentral","atcCode":"N06BA06","allCodes":["N06BA06"]},"biosimilarFilings":[],"recentPublications":[{"date":"1985 Apr 20","pmid":"2859077","title":"Amphetamine, mazindol, and fencamfamin in narcolepsy.","journal":"British medical journal (Clinical research ed.)"},{"date":"1969 Oct","pmid":"5348439","title":"Interactions of oestrogenic and progestational steroids with dexamphetamine and fencamfamin in mice.","journal":"British journal of pharmacology"},{"date":"1968","pmid":"4239211","title":"[Reserpine-parkinsonoid syndrome in the chimpanzee and its treatment with fencamfamin].","journal":"Naunyn-Schmiedebergs Archiv fur experimentelle Pathologie und Pharmakologie"},{"date":"1966 Feb","pmid":"5943119","title":"An EEG study of 2-phynyl-3-ethylaminobicyclo-(2,2,1)-hepatane HCl (fencamfamin hydrochloride).","journal":"Life sciences"},{"date":"1964 Sep-Oct","pmid":"14218622","title":"FENCAMFAMIN VERSUS PLACEBO IN DEPRESSED PATIENTS.","journal":"The Journal of new drugs"}],"companionDiagnostics":[],"genericManufacturerList":[],"status":"active","companyName":"","companyId":"","modality":"Small molecule","firstApprovalDate":"","aiSummary":"Reactivan (FENCAMFAMIN) is a small molecule drug in the fencamfamin class, but information on its target and mechanism of action is limited. Its commercial status and approved indications are also unknown. As a result, there is limited information available on its safety profile and pharmacokinetic properties. Further research is needed to fully understand Reactivan's potential therapeutic applications and risks. Its current owner and development status are also unclear.","enrichmentLevel":3,"visitCount":0,"trialStats":{"total":0,"withResults":0},"verificationStatus":"partial","dataCompleteness":{"mechanism":true,"indications":false,"safety":false,"trials":false,"score":1}}