{"id":"fenbutrazate","rwe":[{"pmid":"38715742","year":"2021","title":"Ultra-high performance supercritical fluid chromatography coupled to tandem mass spectrometry for antidoping analyses: Assessment of the inter-laboratory reproducibility with urine samples.","finding":"","journal":"Analytical science advances","studyType":"Clinical Study"},{"pmid":"24849814","year":"2014","title":"Pharmacophore modeling, virtual screening, and in vitro testing reveal haloperidol, eprazinone, and fenbutrazate as neurokinin receptors ligands.","finding":"","journal":"Journal of chemical information and modeling","studyType":"Clinical Study"}],"tags":[{"label":"fenbutrazate","category":"class"},{"label":"Small Molecule","category":"modality"},{"label":"Active","category":"status"}],"phase":"phase_2","safety":{},"trials":[],"aliases":[],"patents":[],"pricing":[],"allNames":"nethanol","offLabel":[],"synonyms":["fenbutrazate","fenbutrazatum","nethanol","phenbutrazate","phenbutrazatum","fenbutrazate hydrochloride","fenbutrazate HCl","phenbutrazate hydrochloride","phenbutrazate HCl"],"timeline":[],"approvals":[],"brandName":"Nethanol","ecosystem":[],"mechanism":{"modality":"Small Molecule","drugClass":"fenbutrazate","explanation":"Imagine your brain is a city with many different neighborhoods, each with its own unique culture and way of communicating. Fenbutrazate is like a special kind of traffic cop that helps regulate the flow of information between these neighborhoods, influencing how they work together to control mood and other functions.","oneSentence":"Fenbutrazate is thought to work by modulating neurotransmitter activity in the brain.","technicalDetail":"Fenbutrazate is a phenylalkylamine derivative that acts as a monoamine reuptake inhibitor, increasing the levels of certain neurotransmitters such as dopamine, norepinephrine, and serotonin in the synaptic cleft."},"commercial":{},"references":[{"id":1,"url":"https://drugcentral.org/drugcard/3222","fields":["approvals","synonyms","ATC","PK","indications","contraindications","DDIs","targets","patents","FAERS"],"source":"DrugCentral"},{"id":2,"url":"https://pubmed.ncbi.nlm.nih.gov/?term=FENBUTRAZATE","fields":["publications"],"source":"PubMed/NCBI"}],"_enrichedAt":"2026-03-30T11:29:47.426397","biosimilars":[],"competitors":[],"genericName":"fenbutrazate","indications":{"approved":[],"offLabel":[],"pipeline":[]},"drugCategory":"active","labelChanges":[],"relatedDrugs":[],"trialDetails":[],"genericFilers":[],"latestUpdates":[],"manufacturing":[],"crossReferences":{"NDDF":"006532","UNII":"BKY8H56395","CHEBI":"CHEBI:135551","INN_ID":"1120","RXNORM":"158507","UMLSCUI":"C0605193","ChEMBL_ID":"CHEMBL2104316","PUBCHEM_CID":"20395","SECONDARY_CAS_RN":"6474-85-7","MESH_SUPPLEMENTAL_RECORD_UI":"C012318"},"formularyStatus":[],"_enricherVersion":"v2","developmentCodes":[],"ownershipHistory":[],"publicationCount":2,"therapeuticAreas":["Neuroscience"],"biosimilarFilings":[],"recentPublications":[{"date":"2021 Feb","pmid":"38715742","title":"Ultra-high performance supercritical fluid chromatography coupled to tandem mass spectrometry for antidoping analyses: Assessment of the inter-laboratory reproducibility with urine samples.","journal":"Analytical science advances"},{"date":"2014 Jun 23","pmid":"24849814","title":"Pharmacophore modeling, virtual screening, and in vitro testing reveal haloperidol, eprazinone, and fenbutrazate as neurokinin receptors ligands.","journal":"Journal of chemical information and modeling"}],"companionDiagnostics":[],"genericManufacturerList":[],"status":"active","companyName":"","companyId":"","modality":"Small molecule","firstApprovalDate":"","aiSummary":"Nethanol, also known as Fenbutrazate, is a small molecule drug in the fenbutrazate class. Its exact target and mechanism of action are unknown, and it has not been approved by the FDA for any indications. The commercial status of Nethanol is unclear, with unknown generic manufacturers and patent status. As a result, key safety considerations and pharmacokinetic properties, such as half-life and bioavailability, are also unknown. Further research is needed to fully understand Nethanol's properties and potential uses.","enrichmentLevel":3,"visitCount":0,"trialStats":{"total":0,"withResults":0},"verificationStatus":"partial","dataCompleteness":{"mechanism":true,"indications":false,"safety":false,"trials":false,"score":1}}