{"id":"fenbufen","rwe":[{"pmid":"41883118","year":"2026","title":"In vitro and preclinical assessment of drug interactions between fluoroquinolones and a non-steroidal anti-inflammatory drug predicting risk of seizure.","finding":"","journal":"Toxicological sciences : an official journal of the Society of Toxicology","studyType":"Clinical Study"},{"pmid":"41860447","year":"2026","title":"Dual Inhibition of COX-2/5-LOX Through Novel Hybrids of NSAIDs and Peptides: Insights from Molecular Dynamics Simulation and Per-Residue Decomposition.","finding":"","journal":"ChemistryOpen","studyType":"Clinical Study"},{"pmid":"40733050","year":"2025","title":"Screening for Polymorphism, Cyclodextrin Complexation, and Co-Crystallization of the Non-Steroidal Anti-Inflammatory Drug Fenbufen: Isolation and Characterization of a Co-Crystal and an Ionic Co-Crystal of the API with a Common Coformer.","finding":"","journal":"Pharmaceutics","studyType":"Clinical Study"},{"pmid":"38203583","year":"2023","title":"Advantages of Induced Circular Dichroism Spectroscopy for Qualitative and Quantitative Analysis of Solution-Phase Cyclodextrin Host-Guest Complexes.","finding":"","journal":"International journal of molecular sciences","studyType":"Clinical Study"},{"pmid":"37204093","year":"2023","title":"Continuous-Flow Suzuki-Miyaura Coupling in Water and Organic Solvents Promoted by Blends of Stabilized Convoluted Polymeric Palladium Catalysts and Polymeric Auxiliary Materials.","finding":"","journal":"Chemistry (Weinheim an der Bergstrasse, Germany)","studyType":"Clinical Study"}],"tags":[{"label":"fenbufen","category":"class"},{"label":"Small Molecule","category":"modality"},{"label":"Prostaglandin G/H synthase 1","category":"target"},{"label":"PTGS1","category":"gene"},{"label":"PTGS2","category":"gene"},{"label":"M01AE05","category":"atc"},{"label":"Active","category":"status"},{"label":"Analgesics","category":"pharmacology"},{"label":"Analgesics, Non-Narcotic","category":"pharmacology"},{"label":"Anti-Inflammatory Agents","category":"pharmacology"},{"label":"Anti-Inflammatory Agents, Non-Steroidal","category":"pharmacology"},{"label":"Antirheumatic Agents","category":"pharmacology"},{"label":"Cyclooxygenase Inhibitors","category":"pharmacology"},{"label":"Enzyme Inhibitors","category":"pharmacology"},{"label":"Peripheral Nervous System Agents","category":"pharmacology"},{"label":"Sensory System Agents","category":"pharmacology"}],"phase":"phase_2","safety":{},"trials":[],"aliases":[],"patents":[],"pricing":[],"allNames":"bufemid","offLabel":[],"synonyms":["fenbufen","bufemid","lederfen","napanol"],"timeline":[],"approvals":[],"brandName":"Bufemid","ecosystem":[],"mechanism":{"target":"Prostaglandin G/H synthase 1, Prostaglandin G/H synthase 2, Prostaglandin G/H synthase 1","targets":[{"gene":"PTGS1","source":"DrugCentral","target":"Prostaglandin G/H synthase 1","protein":"Prostaglandin G/H synthase 1"},{"gene":"PTGS2","source":"DrugCentral","target":"Prostaglandin G/H synthase 2","protein":"Prostaglandin G/H synthase 2"}],"modality":"Small Molecule","drugClass":"fenbufen","explanation":"Think of prostaglandins like messengers that tell your body to get inflamed. Bufemid blocks these messengers from being made, which helps to reduce inflammation and relieve pain. This can be especially helpful for people with conditions like arthritis or other inflammatory diseases.","oneSentence":"Bufemid works by inhibiting the enzyme Prostaglandin G/H synthase 1, which is responsible for producing prostaglandins that cause inflammation.","technicalDetail":"Bufemid exerts its anti-inflammatory effects by competitively inhibiting the cyclooxygenase (COX) activity of Prostaglandin G/H synthase 1, thereby reducing the production of prostaglandins and thromboxanes."},"commercial":{},"references":[{"id":1,"url":"https://drugcentral.org/drugcard/1145","fields":["approvals","synonyms","ATC","PK","indications","contraindications","DDIs","targets","patents","FAERS"],"source":"DrugCentral"},{"id":2,"url":"https://pubmed.ncbi.nlm.nih.gov/?term=FENBUFEN","fields":["publications"],"source":"PubMed/NCBI"}],"_enrichedAt":"2026-03-30T11:14:36.164092","biosimilars":[],"competitors":[{"drugName":"ibuprofen","drugSlug":"ibuprofen","fdaApproval":"1974-09-19","patentExpiry":"Sep 30, 2029","patentStatus":"Patent protected","relationship":"same-class"},{"drugName":"naproxen","drugSlug":"naproxen","fdaApproval":"1976-03-11","genericCount":31,"patentStatus":"Off-patent — generic available","relationship":"same-class"},{"drugName":"ketoprofen","drugSlug":"ketoprofen","fdaApproval":"1986-01-09","genericCount":7,"patentStatus":"Off-patent — generic available","relationship":"same-class"},{"drugName":"fenoprofen","drugSlug":"fenoprofen","fdaApproval":"1976-03-16","genericCount":16,"patentStatus":"Off-patent — generic available","relationship":"same-class"},{"drugName":"benoxaprofen","drugSlug":"benoxaprofen","fdaApproval":"1982-04-19","relationship":"same-class"},{"drugName":"suprofen","drugSlug":"suprofen","fdaApproval":"1988-12-23","patentStatus":"Unknown","relationship":"same-class"},{"drugName":"flurbiprofen","drugSlug":"flurbiprofen","fdaApproval":"1986-12-31","genericCount":8,"patentStatus":"Off-patent — generic available","relationship":"same-class"},{"drugName":"oxaprozin","drugSlug":"oxaprozin","fdaApproval":"1992-10-29","genericCount":13,"patentStatus":"Off-patent — generic available","relationship":"same-class"},{"drugName":"esomeprazole","drugSlug":"esomeprazole","fdaApproval":"2001-02-20","patentExpiry":"Dec 8, 2036","patentStatus":"Patent protected","relationship":"same-class"},{"drugName":"misoprostol","drugSlug":"misoprostol","fdaApproval":"1988-12-27","genericCount":4,"patentStatus":"Off-patent — generic available","relationship":"same-class"}],"dataSources":[{"url":"https://drugcentral.org","name":"DrugCentral","fields":["indications","contraindications","safety","target","drugInteractions"],"retrievedDate":"2026-04-07"}],"genericName":"fenbufen","indications":{"approved":[],"offLabel":[],"pipeline":[]},"drugCategory":"active","labelChanges":[],"relatedDrugs":[{"drugId":"ibuprofen","brandName":"ibuprofen","genericName":"ibuprofen","approvalYear":"1974","relationship":"same-class"},{"drugId":"naproxen","brandName":"naproxen","genericName":"naproxen","approvalYear":"1976","relationship":"same-class"},{"drugId":"ketoprofen","brandName":"ketoprofen","genericName":"ketoprofen","approvalYear":"1986","relationship":"same-class"},{"drugId":"fenoprofen","brandName":"fenoprofen","genericName":"fenoprofen","approvalYear":"1976","relationship":"same-class"},{"drugId":"benoxaprofen","brandName":"benoxaprofen","genericName":"benoxaprofen","approvalYear":"1982","relationship":"same-class"},{"drugId":"suprofen","brandName":"suprofen","genericName":"suprofen","approvalYear":"1988","relationship":"same-class"},{"drugId":"flurbiprofen","brandName":"flurbiprofen","genericName":"flurbiprofen","approvalYear":"1986","relationship":"same-class"},{"drugId":"oxaprozin","brandName":"oxaprozin","genericName":"oxaprozin","approvalYear":"1992","relationship":"same-class"},{"drugId":"esomeprazole","brandName":"esomeprazole","genericName":"esomeprazole","approvalYear":"2001","relationship":"same-class"},{"drugId":"misoprostol","brandName":"misoprostol","genericName":"misoprostol","approvalYear":"1988","relationship":"same-class"}],"trialDetails":[],"genericFilers":[],"latestUpdates":[],"manufacturing":[],"administration":{},"crossReferences":{"NDDF":"004090","UNII":"9815R1WR9B","CHEBI":"CHEBI:31599","INN_ID":"3439","RXNORM":"151967","UMLSCUI":"C0060156","ChEMBL_ID":"CHEMBL277522","KEGG_DRUG":"D01344","DRUGBANK_ID":"DB08981","PUBCHEM_CID":"3335","SNOMEDCT_US":"329623001","MESH_SUPPLEMENTAL_RECORD_UI":"C010725"},"formularyStatus":[],"_enricherVersion":"v2","developmentCodes":[],"ownershipHistory":[],"pharmacokinetics":{"source":"DrugCentral","bioavailability":"78%"},"publicationCount":285,"therapeuticAreas":["Immunology"],"atcClassification":{"source":"DrugCentral","atcCode":"M01AE05","allCodes":["M01AE05"]},"biosimilarFilings":[],"recentPublications":[{"date":"2026 Mar 25","pmid":"41883118","title":"In vitro and preclinical assessment of drug interactions between fluoroquinolones and a non-steroidal anti-inflammatory drug predicting risk of seizure.","journal":"Toxicological sciences : an official journal of the Society of Toxicology"},{"date":"2026 Mar","pmid":"41860447","title":"Dual Inhibition of COX-2/5-LOX Through Novel Hybrids of NSAIDs and Peptides: Insights from Molecular Dynamics Simulation and Per-Residue Decomposition.","journal":"ChemistryOpen"},{"date":"2025 Jun 27","pmid":"40733050","title":"Screening for Polymorphism, Cyclodextrin Complexation, and Co-Crystallization of the Non-Steroidal Anti-Inflammatory Drug Fenbufen: Isolation and Characterization of a Co-Crystal and an Ionic Co-Crystal of the API with a Common Coformer.","journal":"Pharmaceutics"},{"date":"2023 Dec 28","pmid":"38203583","title":"Advantages of Induced Circular Dichroism Spectroscopy for Qualitative and Quantitative Analysis of Solution-Phase Cyclodextrin Host-Guest Complexes.","journal":"International journal of molecular sciences"},{"date":"2023 Jun 19","pmid":"37204093","title":"Continuous-Flow Suzuki-Miyaura Coupling in Water and Organic Solvents Promoted by Blends of Stabilized Convoluted Polymeric Palladium Catalysts and Polymeric Auxiliary Materials.","journal":"Chemistry (Weinheim an der Bergstrasse, Germany)"}],"companionDiagnostics":[],"genericManufacturerList":[],"status":"active","companyName":"","companyId":"","modality":"Small molecule","firstApprovalDate":"","aiSummary":"Bufemid (FENBUFEN) is a small molecule drug that targets Prostaglandin G/H synthase 1, a key enzyme involved in inflammation. It belongs to the fenbufen class and is used to treat various inflammatory conditions. However, its commercial status and approved indications are unknown. Bufemid's safety profile and pharmacokinetic properties, such as half-life and bioavailability, are also not well-documented. Further research is needed to fully understand its clinical utility and potential risks.","enrichmentLevel":3,"visitCount":0,"trialStats":{"total":0,"withResults":0},"verificationStatus":"partial","dataCompleteness":{"mechanism":true,"indications":false,"safety":false,"trials":false,"score":1}}