{"id":"femoxetine","rwe":[{"pmid":"36806856","year":"2023","title":"Enantioselective conjugate addition of malonates to α,β-unsaturated aldehydes catalysed by 4-oxalocrotonate tautomerase.","finding":"","journal":"Organic & biomolecular chemistry","studyType":"Clinical Study"},{"pmid":"25485210","year":"2014","title":"Rapid Construction of (-)-Paroxetine and (-)-Femoxetine via N-Heterocyclic Carbene Catalyzed Homoenolate Addition to Nitroalkenes.","finding":"","journal":"Asian journal of organic chemistry","studyType":"Clinical Study"},{"pmid":"18254030","year":"2008","title":"Antidepressant drugs for narcolepsy.","finding":"","journal":"The Cochrane database of systematic reviews","studyType":"Clinical Study"},{"pmid":"17403708","year":"2007","title":"Reversal of resistance in microorganisms by help of non-antibiotics.","finding":"","journal":"The Journal of antimicrobial chemotherapy","studyType":"Clinical Study"},{"pmid":"16034909","year":"2005","title":"Antidepressant drugs for narcolepsy.","finding":"","journal":"The Cochrane database of systematic reviews","studyType":"Clinical Study"}],"tags":[{"label":"femoxetine","category":"class"},{"label":"Small Molecule","category":"modality"},{"label":"Sodium-dependent serotonin transporter","category":"target"},{"label":"SLC6A4","category":"gene"},{"label":"CHRM1","category":"gene"},{"label":"CHRM2","category":"gene"},{"label":"Active","category":"status"},{"label":"Anti-Infective Agents","category":"pharmacology"},{"label":"Antidepressive Agents","category":"pharmacology"},{"label":"Central Nervous System Agents","category":"pharmacology"},{"label":"Membrane Transport Modulators","category":"pharmacology"},{"label":"Neurotransmitter Agents","category":"pharmacology"},{"label":"Neurotransmitter Uptake Inhibitors","category":"pharmacology"},{"label":"Psychotropic Drugs","category":"pharmacology"},{"label":"Selective Serotonin Reuptake Inhibitors","category":"pharmacology"},{"label":"Serotonin Agents","category":"pharmacology"}],"phase":"phase_2","safety":{},"trials":[],"aliases":[],"patents":[],"pricing":[],"allNames":["femoxetine"],"offLabel":[],"synonyms":["femoxetine"],"timeline":[],"approvals":[],"ecosystem":[],"mechanism":{"target":"5-hydroxytryptamine receptor 1A, D(2) dopamine receptor, Histamine H1 receptor","targets":[{"gene":"SLC6A4","source":"DrugCentral","target":"Sodium-dependent serotonin transporter","protein":"Sodium-dependent serotonin transporter"},{"gene":"CHRM1","source":"DrugCentral","target":"Muscarinic acetylcholine receptor M1","protein":"Muscarinic acetylcholine receptor M1"},{"gene":"CHRM2","source":"DrugCentral","target":"Muscarinic acetylcholine receptor M2","protein":"Muscarinic acetylcholine receptor M2"},{"gene":"CHRM3","source":"DrugCentral","target":"Muscarinic acetylcholine receptor M3","protein":"Muscarinic acetylcholine receptor M3"},{"gene":"CHRM5","source":"DrugCentral","target":"Muscarinic acetylcholine receptor M5","protein":"Muscarinic acetylcholine receptor M5"},{"gene":"CHRM4","source":"DrugCentral","target":"Muscarinic acetylcholine receptor M4","protein":"Muscarinic acetylcholine receptor M4"},{"gene":"DRD2","source":"DrugCentral","target":"D(2) dopamine receptor","protein":"D(2) dopamine receptor"},{"gene":"SLC6A2","source":"DrugCentral","target":"Sodium-dependent noradrenaline transporter","protein":"Sodium-dependent noradrenaline transporter"},{"gene":"SLC6A3","source":"DrugCentral","target":"Sodium-dependent dopamine transporter","protein":"Sodium-dependent dopamine transporter"},{"gene":"HTR1A","source":"DrugCentral","target":"5-hydroxytryptamine receptor 1A","protein":"5-hydroxytryptamine receptor 1A"}],"modality":"Small Molecule","drugClass":"femoxetine","explanation":"Think of serotonin like a messenger in your brain. When serotonin is released, it helps to regulate mood, appetite, and sleep. By blocking the reuptake of serotonin, femoxetine allows these messengers to stay in the brain longer, which can help improve mood and reduce symptoms of depression.","oneSentence":"Femoxetine works by blocking the reuptake of serotonin, allowing more of this neurotransmitter to be available in the brain.","technicalDetail":"Femoxetine acts as a selective serotonin reuptake inhibitor (SSRI) by binding to the sodium-dependent serotonin transporter (SERT), preventing the reuptake of serotonin into presynaptic neurons and increasing its availability in the synaptic cleft."},"commercial":{},"references":[{"id":1,"url":"https://drugcentral.org/drugcard/3220","fields":["approvals","synonyms","ATC","PK","indications","contraindications","DDIs","targets","patents","FAERS"],"source":"DrugCentral"},{"id":2,"url":"https://pubmed.ncbi.nlm.nih.gov/?term=FEMOXETINE","fields":["publications"],"source":"PubMed/NCBI"}],"_enrichedAt":"2026-03-30T11:29:43.963506","biosimilars":[],"competitors":[{"drugName":"acepromazine","drugSlug":"acepromazine","fdaApproval":"","relationship":"same-target"},{"drugName":"acetophenazine","drugSlug":"acetophenazine","fdaApproval":"1961-04-05","patentStatus":"Unknown","relationship":"same-target"},{"drugName":"amiodarone","drugSlug":"amiodarone","fdaApproval":"1985-12-24","patentExpiry":"Mar 13, 2029","patentStatus":"Patent protected","relationship":"same-target"},{"drugName":"amisulpride","drugSlug":"amisulpride","fdaApproval":"2020-02-26","patentExpiry":"Mar 10, 2031","patentStatus":"Patent protected","relationship":"same-target"},{"drugName":"amitriptyline","drugSlug":"amitriptyline","fdaApproval":"1961-04-07","genericCount":33,"patentStatus":"Off-patent — generic available","relationship":"same-target"},{"drugName":"amoxapine","drugSlug":"amoxapine","fdaApproval":"1980-09-22","genericCount":3,"patentStatus":"Off-patent — generic available","relationship":"same-target"},{"drugName":"apomorphine","drugSlug":"apomorphine","fdaApproval":"2004-04-20","patentExpiry":"Jun 11, 2030","patentStatus":"Patent protected","relationship":"same-target"},{"drugName":"aripiprazole","drugSlug":"aripiprazole","fdaApproval":"2002-11-15","patentExpiry":"Sep 24, 2033","patentStatus":"Patent protected","relationship":"same-target"},{"drugName":"aripiprazole lauroxil","drugSlug":"aripiprazole-lauroxil","fdaApproval":"2015-10-05","patentExpiry":"Sep 8, 2035","patentStatus":"Patent 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available","relationship":"same-target"}],"dataSources":[{"url":"https://drugcentral.org","name":"DrugCentral","fields":["indications","contraindications","safety","target","drugInteractions"],"retrievedDate":"2026-04-07"}],"genericName":"femoxetine","indications":{"approved":[],"offLabel":[],"pipeline":[]},"drugCategory":"active","labelChanges":[],"relatedDrugs":[{"drugId":"acepromazine","brandName":"acepromazine","genericName":"acepromazine","approvalYear":"","relationship":"same-target"},{"drugId":"acetophenazine","brandName":"acetophenazine","genericName":"acetophenazine","approvalYear":"1961","relationship":"same-target"},{"drugId":"amiodarone","brandName":"amiodarone","genericName":"amiodarone","approvalYear":"1985","relationship":"same-target"},{"drugId":"amisulpride","brandName":"amisulpride","genericName":"amisulpride","approvalYear":"2020","relationship":"same-target"},{"drugId":"amitriptyline","brandName":"amitriptyline","genericName":"amitriptyline","approvalYear":"1961","relationship":"same-target"},{"drugId":"amoxapine","brandName":"amoxapine","genericName":"amoxapine","approvalYear":"1980","relationship":"same-target"},{"drugId":"apomorphine","brandName":"apomorphine","genericName":"apomorphine","approvalYear":"2004","relationship":"same-target"},{"drugId":"aripiprazole","brandName":"aripiprazole","genericName":"aripiprazole","approvalYear":"2002","relationship":"same-target"},{"drugId":"aripiprazole-lauroxil","brandName":"aripiprazole lauroxil","genericName":"aripiprazole lauroxil","approvalYear":"2015","relationship":"same-target"},{"drugId":"armodafinil","brandName":"armodafinil","genericName":"armodafinil","approvalYear":"2007","relationship":"same-target"}],"trialDetails":[],"genericFilers":[],"latestUpdates":[],"manufacturing":[],"administration":{},"crossReferences":{"UNII":"8Y719ZLX8C","INN_ID":"4032","UMLSCUI":"C0060145","ChEMBL_ID":"CHEMBL94739","PUBCHEM_CID":"3012003","MESH_SUPPLEMENTAL_RECORD_UI":"C010655"},"formularyStatus":[],"_enricherVersion":"v2","developmentCodes":[],"ownershipHistory":[],"pharmacokinetics":{"source":"DrugCentral","bioavailability":"8%"},"publicationCount":71,"therapeuticAreas":["Neuroscience"],"biosimilarFilings":[],"recentPublications":[{"date":"2023 Mar 8","pmid":"36806856","title":"Enantioselective conjugate addition of malonates to α,β-unsaturated aldehydes catalysed by 4-oxalocrotonate tautomerase.","journal":"Organic & biomolecular chemistry"},{"date":"2014 Apr","pmid":"25485210","title":"Rapid Construction of (-)-Paroxetine and (-)-Femoxetine via N-Heterocyclic Carbene Catalyzed Homoenolate Addition to Nitroalkenes.","journal":"Asian journal of organic chemistry"},{"date":"2008 Jan 23","pmid":"18254030","title":"Antidepressant drugs for narcolepsy.","journal":"The Cochrane database of systematic reviews"},{"date":"2007 Jun","pmid":"17403708","title":"Reversal of resistance in microorganisms by help of non-antibiotics.","journal":"The Journal of antimicrobial chemotherapy"},{"date":"2005 Jul 20","pmid":"16034909","title":"Antidepressant drugs for narcolepsy.","journal":"The Cochrane database of systematic reviews"}],"companionDiagnostics":[],"genericManufacturerList":[],"status":"active","brandName":"FEMOXETINE","companyName":"","companyId":"","modality":"Small molecule","firstApprovalDate":"","aiSummary":"Femoxetine is a small molecule drug that targets the sodium-dependent serotonin transporter. It is classified as a femoxetine, a type of antidepressant. However, its commercial status and approved indications are unknown. Femoxetine works by inhibiting the reuptake of serotonin, allowing more of this neurotransmitter to be available in the brain. Further information on its safety and efficacy is needed.","enrichmentLevel":3,"visitCount":0,"trialStats":{"total":0,"withResults":0},"verificationStatus":"partial","dataCompleteness":{"mechanism":true,"indications":false,"safety":false,"trials":false,"score":1}}