{"id":"femanest-plus-gestapuran","safety":{"commonSideEffects":[{"rate":null,"effect":"Nausea"},{"rate":null,"effect":"Breast tenderness"},{"rate":null,"effect":"Headache"},{"rate":null,"effect":"Vaginal bleeding or spotting"}]},"_chembl":null,"_dailymed":null,"mechanism":{"_ai_source":"claude-haiku-4.5","explanation":"The drug combines estrogen and progestin components to provide hormonal support during early pregnancy. Gestapuran (a progestin) helps maintain the endometrium and supports corpus luteum function, while the estrogen component may enhance uterine receptivity and placental development. This combination is intended to reduce the risk of recurrent miscarriage in women with hormonal insufficiency.","oneSentence":"Femanest plus Gestapuran is a hormonal combination therapy designed to support pregnancy maintenance and reduce miscarriage risk through progestin supplementation.","_ai_confidence":"low"},"_scrapedAt":"2026-03-28T00:46:47.035Z","_scrapedBy":"cloudflare-swarm","_wikipedia":null,"indications":{"approved":[{"name":"Recurrent miscarriage prevention in early pregnancy"},{"name":"Luteal phase support in assisted reproductive technology"}]},"trialDetails":[{"nctId":"NCT00564031","phase":"PHASE3","title":"Hormonal Replacement Therapy and Small Artery Function","status":"COMPLETED","sponsor":"Karolinska University Hospital","startDate":"2003-01","conditions":"Menopause","enrollment":66}],"_emaApprovals":[],"_faersSignals":[],"_approvalHistory":[],"publicationCount":0,"rwe":[],"genericFilers":[],"relatedDrugs":[],"labelChanges":[],"biosimilarFilings":[],"pricing":[],"formularyStatus":[],"manufacturing":[],"companionDiagnostics":[],"competitors":[],"timeline":[],"patents":[],"ownershipHistory":[],"trials":[],"biosimilars":[],"latestUpdates":[],"references":[],"tags":[],"ecosystem":[],"genericManufacturerList":[],"offLabel":[],"developmentCodes":[],"aliases":[],"phase":"phase_3","status":"active","brandName":"Femanest plus Gestapuran","genericName":"Femanest plus Gestapuran","companyName":"Karolinska University Hospital","companyId":"karolinska-university-hospital","modality":"Small molecule","firstApprovalDate":"","aiSummary":"Femanest plus Gestapuran is a hormonal combination therapy designed to support pregnancy maintenance and reduce miscarriage risk through progestin supplementation. Used for Recurrent miscarriage prevention in early pregnancy, Luteal phase support in assisted reproductive technology.","enrichmentLevel":3,"visitCount":0,"trialStats":{"total":0,"withResults":0},"verificationStatus":"verified","dataCompleteness":{"mechanism":true,"indications":true,"safety":true,"trials":true,"score":4}}