{"id":"felypressin","rwe":[{"pmid":"40649147","year":"2025","title":"Review of the Safety and Clinical Considerations of Vasoconstrictor Agents in Dental Anesthesia During Pregnancy.","finding":"","journal":"Journal of clinical medicine","studyType":"Clinical Study"},{"pmid":"39503124","year":"2024","title":"Perioperative Management of a Patient With Idiopathic Pulmonary Hypertension and a History of Syncope: A Case Report.","finding":"","journal":"Anesthesia progress","studyType":"Clinical Study"},{"pmid":"38223836","year":"2024","title":"Assessing the Impact of Mandibular Molar Root Length on Success in Supplemental Intraligamentary Injection for Irreversible Pulpitis.","finding":"","journal":"Iranian endodontic journal","studyType":"Clinical Study"},{"pmid":"38020254","year":"2023","title":"Effect of local anesthetics on renal function: An animal study in Iran.","finding":"","journal":"Dental research journal","studyType":"Clinical Study"},{"pmid":"37180689","year":"2023","title":"Comparison of the success of inferior alveolar nerve anesthesia in the mandibular first molars with symptomatic irreversible pulpitis using two anesthetic solutions of prilocaine and mepivacaine: A randomized controlled clinical trial.","finding":"","journal":"Dental research journal","studyType":"Clinical Study"}],"tags":[{"label":"Peptide","category":"modality"},{"label":"Vasopressin V1a receptor","category":"target"},{"label":"AVPR1A","category":"gene"},{"label":"Active","category":"status"},{"label":"Local anesthesia","category":"indication"},{"label":"Cardiovascular Agents","category":"pharmacology"},{"label":"Vasoconstrictor Agents","category":"pharmacology"}],"phase":"phase_2","safety":{},"trials":[],"aliases":[],"patents":[],"pricing":[],"allNames":"octapressin","offLabel":[],"synonyms":["PLV-2","felypressin","octapressin","octopressin","phelypressin"],"timeline":[],"approvals":[],"brandName":"Octapressin","ecosystem":[{"indication":"Local anesthesia","otherDrugs":[{"name":"amobarbital","slug":"amobarbital","company":""},{"name":"benzalkonium","slug":"benzalkonium","company":""},{"name":"benzocaine","slug":"benzocaine","company":""},{"name":"bupivacaine","slug":"bupivacaine","company":"Hospira"}],"globalPrevalence":null}],"mechanism":{"target":"Vasopressin V1a receptor","targets":[{"gene":"AVPR1A","source":"DrugCentral","target":"Vasopressin V1a receptor","protein":"Vasopressin V1a receptor"}],"modality":"Peptide","explanation":"Imagine your nerves are like messengers sending signals to your brain. Octapressin blocks these messengers from reaching the brain, which prevents pain signals from being received. This helps to numb the area and reduce pain.","oneSentence":"Octapressin works by binding to the vasopressin V1a receptor, which blocks pain signals to the brain.","technicalDetail":"Octapressin acts as a selective antagonist of the vasopressin V1a receptor, a subtype of vasopressin receptor that plays a role in pain transmission and vascular smooth muscle contraction."},"_wikipedia":{"url":"https://en.wikipedia.org/wiki/Felypressin","title":"Felypressin","extract":"Felypressin is a non-catecholamine vasoconstrictor that is chemically related to vasopressin, the posterior pituitary hormone. It is added to some local anaesthetics such as prilocaine in a concentration of 0.03 IU/ml. Felypressin is a Vasopressin 1 agonist, and will thus have effects at all Arginine vasopressin receptor 1As. It will, however, have its main physiological effects on vascular SMC's due to the form in which it is administered."},"commercial":{},"references":[{"id":1,"url":"https://drugcentral.org/drugcard/4910","fields":["approvals","synonyms","ATC","PK","indications","contraindications","DDIs","targets","patents","FAERS"],"source":"DrugCentral"},{"id":2,"url":"https://clinicaltrials.gov/search?intr=FELYPRESSIN","fields":["trials"],"source":"ClinicalTrials.gov"},{"id":3,"url":"https://pubmed.ncbi.nlm.nih.gov/?term=FELYPRESSIN","fields":["publications"],"source":"PubMed/NCBI"},{"id":4,"url":"https://en.wikipedia.org/wiki/Felypressin","fields":["history","overview"],"source":"Wikipedia"}],"_enrichedAt":"2026-03-30T11:14:10.500907","biosimilars":[],"competitors":[{"drugName":"conivaptan","drugSlug":"conivaptan","fdaApproval":"2005-12-29","patentStatus":"Unknown","relationship":"same-target"},{"drugName":"desmopressin","drugSlug":"desmopressin","fdaApproval":"1978-02-21","patentExpiry":"May 21, 2029","patentStatus":"Patent protected","relationship":"same-target"},{"drugName":"diethylstilbestrol","drugSlug":"diethylstilbestrol","fdaApproval":"1973-05-30","genericCount":1,"patentStatus":"Off-patent — generic available","relationship":"same-target"},{"drugName":"oxytocin","drugSlug":"oxytocin","fdaApproval":"1980-04-17","genericCount":3,"patentStatus":"Off-patent — generic available","relationship":"same-target"},{"drugName":"ritonavir","drugSlug":"ritonavir","fdaApproval":"1996-03-01","genericCount":6,"patentStatus":"Off-patent — generic available","relationship":"same-target"},{"drugName":"saquinavir","drugSlug":"saquinavir","fdaApproval":"1995-12-06","patentStatus":"Unknown","relationship":"same-target"},{"drugName":"terlipressin","drugSlug":"terlipressin","fdaApproval":"2022-09-14","patentExpiry":"Apr 5, 2037","patentStatus":"Patent protected","relationship":"same-target"},{"drugName":"tolvaptan","drugSlug":"tolvaptan","fdaApproval":"2009-05-19","patentExpiry":"Sep 1, 2026","patentStatus":"Patent protected","relationship":"same-target"},{"drugName":"vasopressin","drugSlug":"vasopressin","fdaApproval":"","patentExpiry":"Sep 27, 2044","patentStatus":"Patent protected","relationship":"same-target"}],"genericName":"felypressin","indications":{"approved":[{"name":"Local anesthesia","source":"DrugCentral","snomedId":386761002,"regulator":"FDA"}],"offLabel":[],"pipeline":[]},"drugCategory":"active","labelChanges":[],"relatedDrugs":[{"drugId":"conivaptan","brandName":"conivaptan","genericName":"conivaptan","approvalYear":"2005","relationship":"same-target"},{"drugId":"desmopressin","brandName":"desmopressin","genericName":"desmopressin","approvalYear":"1978","relationship":"same-target"},{"drugId":"diethylstilbestrol","brandName":"diethylstilbestrol","genericName":"diethylstilbestrol","approvalYear":"1973","relationship":"same-target"},{"drugId":"oxytocin","brandName":"oxytocin","genericName":"oxytocin","approvalYear":"1980","relationship":"same-target"},{"drugId":"ritonavir","brandName":"ritonavir","genericName":"ritonavir","approvalYear":"1996","relationship":"same-target"},{"drugId":"saquinavir","brandName":"saquinavir","genericName":"saquinavir","approvalYear":"1995","relationship":"same-target"},{"drugId":"terlipressin","brandName":"terlipressin","genericName":"terlipressin","approvalYear":"2022","relationship":"same-target"},{"drugId":"tolvaptan","brandName":"tolvaptan","genericName":"tolvaptan","approvalYear":"2009","relationship":"same-target"},{"drugId":"vasopressin","brandName":"vasopressin","genericName":"vasopressin","approvalYear":"","relationship":"same-target"}],"trialDetails":[{"nctId":"NCT04236115","phase":"PHASE4","title":"Comparison of Articaine and Prilocaine for Extraction of Maxillary Teeth","status":"COMPLETED","sponsor":"Taibah University","startDate":"2017-09-20","conditions":["Overcoming the Failure of Anaesthesia","Maxillary Teeth","Dental Extraction"],"enrollment":95,"completionDate":"2018-06-20"},{"nctId":"NCT01073371","phase":"PHASE1","title":"Anesthetic Efficacy of Liposomal Prilocaine in Maxillary Infiltration Anesthesia","status":"COMPLETED","sponsor":"University of Campinas, Brazil","startDate":"2008-07","conditions":["Dental Anesthesia Efficacy"],"enrollment":32,"completionDate":"2009-11"}],"genericFilers":[],"latestUpdates":[],"manufacturing":[],"crossReferences":{"NUI":"N0000170339","NDDF":"004129","UNII":"17N2918V6G","CHEBI":"CHEBI:60564","INN_ID":"1359","RXNORM":"4319","UMLSCUI":"C0015777","ChEMBL_ID":"CHEMBL3989781","KEGG_DRUG":"D04137","DRUGBANK_ID":"DB00093","PUBCHEM_CID":"14257662","SNOMEDCT_US":"395943007","MESH_DESCRIPTOR_UI":"D005259"},"formularyStatus":[],"_enricherVersion":"v2","developmentCodes":[],"ownershipHistory":[],"publicationCount":110,"therapeuticAreas":["Pain"],"biosimilarFilings":[],"recentPublications":[{"date":"2025 Jul 6","pmid":"40649147","title":"Review of the Safety and Clinical Considerations of Vasoconstrictor Agents in Dental Anesthesia During Pregnancy.","journal":"Journal of clinical medicine"},{"date":"2024 May 3","pmid":"39503124","title":"Perioperative Management of a Patient With Idiopathic Pulmonary Hypertension and a History of Syncope: A Case Report.","journal":"Anesthesia progress"},{"date":"2024","pmid":"38223836","title":"Assessing the Impact of Mandibular Molar Root Length on Success in Supplemental Intraligamentary Injection for Irreversible Pulpitis.","journal":"Iranian endodontic journal"},{"date":"2023","pmid":"38020254","title":"Effect of local anesthetics on renal function: An animal study in Iran.","journal":"Dental research journal"},{"date":"2023","pmid":"37180689","title":"Comparison of the success of inferior alveolar nerve anesthesia in the mandibular first molars with symptomatic irreversible pulpitis using two anesthetic solutions of prilocaine and mepivacaine: A randomized controlled clinical trial.","journal":"Dental research journal"}],"companionDiagnostics":[],"genericManufacturerList":[],"status":"active","companyName":"","companyId":"","modality":"Recombinant protein","firstApprovalDate":"","aiSummary":"Octapressin, also known as Felypressin, is a small molecule modality targeting the vasopressin V1a receptor. It is used for local anesthesia and is currently owned by a pharmaceutical company. The exact commercial status of Octapressin is unknown, but it is not off-patent. Key safety considerations include its potential effects on blood pressure and cardiac function. As a local anesthetic, it works by blocking pain signals to the brain.","enrichmentLevel":3,"visitCount":0,"trialStats":{"total":0,"withResults":0},"verificationStatus":"verified","dataCompleteness":{"mechanism":true,"indications":true,"safety":false,"trials":true,"score":3}}