{"id":"felodipine-add-metoprolol","safety":{"commonSideEffects":[{"rate":"5-10","effect":"Peripheral edema"},{"rate":"5-10","effect":"Headache"},{"rate":"5-10","effect":"Dizziness"},{"rate":"5-10","effect":"Fatigue"},{"rate":"2-5","effect":"Bradycardia"},{"rate":"2-5","effect":"Flushing"}]},"_chembl":null,"_dailymed":null,"mechanism":{"_ai_source":"claude-haiku-4.5","explanation":"Felodipine is a dihydropyridine calcium channel blocker that inhibits L-type calcium channels in vascular smooth muscle, causing vasodilation. Metoprolol is a selective beta-1 adrenergic receptor antagonist that reduces heart rate and cardiac contractility. Combined, they provide complementary antihypertensive effects through different mechanisms.","oneSentence":"Felodipine and metoprolol together reduce blood pressure by relaxing blood vessels (felodipine) and slowing heart rate (metoprolol).","_ai_confidence":"high"},"_scrapedAt":"2026-03-27T23:30:24.653Z","_scrapedBy":"cloudflare-swarm","_wikipedia":null,"indications":{"approved":[{"name":"Hypertension"},{"name":"Angina pectoris"}]},"trialDetails":[{"nctId":"NCT01238705","phase":"PHASE4","title":"Combined Antihypertensive Therapy and Sexual Dysfunction","status":"UNKNOWN","sponsor":"LanZhou University","startDate":"2008-04","conditions":"Hypertension, Sexual Dysfunction","enrollment":280},{"nctId":"NCT00861016","phase":"PHASE4","title":"Efficacy and Safety of Metoprolol Succinate Prolonged-Release Tablet in Patients With Mild to Moderate Hypertension","status":"COMPLETED","sponsor":"AstraZeneca","startDate":"2005-10","conditions":"Hypertension","enrollment":310}],"_emaApprovals":[],"_faersSignals":[],"_approvalHistory":[],"publicationCount":1,"rwe":[],"genericFilers":[],"relatedDrugs":[],"labelChanges":[],"biosimilarFilings":[],"pricing":[],"formularyStatus":[],"manufacturing":[],"companionDiagnostics":[],"competitors":[],"timeline":[],"patents":[],"ownershipHistory":[],"trials":[],"biosimilars":[],"latestUpdates":[],"references":[],"tags":[],"ecosystem":[],"genericManufacturerList":[],"offLabel":[],"developmentCodes":[],"aliases":["Plendil","Betaloc"],"phase":"marketed","status":"active","brandName":"Felodipine add Metoprolol","genericName":"Felodipine add Metoprolol","companyName":"LanZhou University","companyId":"lanzhou-university","modality":"Small molecule","firstApprovalDate":"","aiSummary":"Felodipine and metoprolol together reduce blood pressure by relaxing blood vessels (felodipine) and slowing heart rate (metoprolol). Used for Hypertension, Angina pectoris.","enrichmentLevel":3,"visitCount":0,"trialStats":{"total":0,"withResults":0},"verificationStatus":"verified","dataCompleteness":{"mechanism":true,"indications":true,"safety":true,"trials":true,"score":4}}