{"id":"felodipine-add-irbesartan","safety":{"commonSideEffects":[{"rate":"5-10","effect":"Peripheral edema"},{"rate":"5-10","effect":"Headache"},{"rate":"3-7","effect":"Dizziness"},{"rate":"2-5","effect":"Fatigue"},{"rate":"2-5","effect":"Flushing"},{"rate":"1-3","effect":"Hyperkalemia"}]},"_chembl":null,"_dailymed":null,"mechanism":{"_ai_source":"claude-haiku-4.5","explanation":"Felodipine is a dihydropyridine calcium channel blocker that prevents calcium influx into vascular smooth muscle cells, causing vasodilation. Irbesartan is an angiotensin II receptor blocker (ARB) that antagonizes AT1 receptors, preventing angiotensin II-mediated vasoconstriction and sodium retention. Together, they provide complementary antihypertensive effects through different mechanisms.","oneSentence":"This combination reduces blood pressure by blocking calcium channels (felodipine) to relax blood vessels and blocking angiotensin II receptors (irbesartan) to reduce vasoconstriction and aldosterone release.","_ai_confidence":"medium"},"_scrapedAt":"2026-03-28T00:39:39.128Z","_scrapedBy":"cloudflare-swarm","_wikipedia":null,"indications":{"approved":[{"name":"Hypertension"}]},"trialDetails":[{"nctId":"NCT01238705","phase":"PHASE4","title":"Combined Antihypertensive Therapy and Sexual Dysfunction","status":"UNKNOWN","sponsor":"LanZhou University","startDate":"2008-04","conditions":"Hypertension, Sexual Dysfunction","enrollment":280}],"_emaApprovals":[],"_faersSignals":[],"_approvalHistory":[],"publicationCount":1,"rwe":[],"genericFilers":[],"relatedDrugs":[],"labelChanges":[],"biosimilarFilings":[],"pricing":[],"formularyStatus":[],"manufacturing":[],"companionDiagnostics":[],"competitors":[],"timeline":[],"patents":[],"ownershipHistory":[],"trials":[],"biosimilars":[],"latestUpdates":[],"references":[],"tags":[],"ecosystem":[],"genericManufacturerList":[],"offLabel":[],"developmentCodes":[],"aliases":["Plendil","Aprovel"],"phase":"marketed","status":"active","brandName":"Felodipine add Irbesartan","genericName":"Felodipine add Irbesartan","companyName":"LanZhou University","companyId":"lanzhou-university","modality":"Small molecule","firstApprovalDate":"","aiSummary":"This combination reduces blood pressure by blocking calcium channels (felodipine) to relax blood vessels and blocking angiotensin II receptors (irbesartan) to reduce vasoconstriction and aldosterone release. Used for Hypertension.","enrichmentLevel":3,"visitCount":1,"trialStats":{"total":0,"withResults":0},"verificationStatus":"verified","dataCompleteness":{"mechanism":true,"indications":true,"safety":true,"trials":true,"score":4}}