{"id":"felbinac","rwe":[{"pmid":"41883118","year":"2026","title":"In vitro and preclinical assessment of drug interactions between fluoroquinolones and a non-steroidal anti-inflammatory drug predicting risk of seizure.","finding":"","journal":"Toxicological sciences : an official journal of the Society of Toxicology","studyType":"Clinical Study"},{"pmid":"41754961","year":"2026","title":"In Vitro Evaluation of Poly(D,L-lactide-co-glycolide) In Situ Gels and Pharmacokinetics Following Subcutaneous Injection in Rats for Model Drugs.","finding":"","journal":"Pharmaceutics","studyType":"Clinical Study"},{"pmid":"41044294","year":"2025","title":"A Novel Felbinac Transdermal Patch with High Permeability: Design, Development and Evaluation.","finding":"","journal":"AAPS PharmSciTech","studyType":"Clinical Study"},{"pmid":"39077557","year":"2024","title":"Many human pharmaceuticals are weak inhibitors of the cytochrome P450 system in rainbow trout (Oncorhynchus mykiss) liver S9 fractions.","finding":"","journal":"Frontiers in toxicology","studyType":"Clinical Study"},{"pmid":"38792157","year":"2024","title":"Experimental and Machine-Learning-Assisted Design of Pharmaceutically Acceptable Deep Eutectic Solvents for the Solubility Improvement of Non-Selective COX Inhibitors Ibuprofen and Ketoprofen.","finding":"","journal":"Molecules (Basel, Switzerland)","studyType":"Clinical Study"}],"tags":[{"label":"felbinac","category":"class"},{"label":"Small Molecule","category":"modality"},{"label":"Prostaglandin G/H synthase 1","category":"target"},{"label":"PTGS1","category":"gene"},{"label":"PTGS2","category":"gene"},{"label":"M02AA08","category":"atc"},{"label":"Active","category":"status"},{"label":"Osteoarthritis","category":"indication"},{"label":"Pain","category":"indication"},{"label":"Analgesics","category":"pharmacology"},{"label":"Analgesics, Non-Narcotic","category":"pharmacology"},{"label":"Anti-Inflammatory Agents","category":"pharmacology"},{"label":"Anti-Inflammatory Agents, Non-Steroidal","category":"pharmacology"},{"label":"Antirheumatic Agents","category":"pharmacology"},{"label":"Peripheral Nervous System Agents","category":"pharmacology"},{"label":"Sensory System Agents","category":"pharmacology"}],"phase":"phase_3","safety":{},"trials":[],"aliases":[],"patents":[],"pricing":[],"allNames":"traxam","offLabel":[],"synonyms":["dolinac","biphenylacetic acid","felbinac","seltouch","traxam","4-Biphenylylacetic acid","p-Biphenylacetic acid"],"timeline":[],"approvals":[],"brandName":"Traxam","ecosystem":[{"indication":"Osteoarthritis","otherDrugs":[{"name":"aceclofenac","slug":"aceclofenac","company":""},{"name":"acetylsalicylic acid","slug":"acetylsalicylic-acid","company":"Endo Pharms"},{"name":"celecoxib","slug":"celecoxib","company":"Gd Searle"},{"name":"choline magnesium trisalicylate","slug":"choline-magnesium-trisalicylate","company":""}],"globalPrevalence":655000000},{"indication":"Pain","otherDrugs":[{"name":"acetylsalicylic acid","slug":"acetylsalicylic-acid","company":"Endo Pharms"},{"name":"bromfenac","slug":"bromfenac","company":"Bausch And Lomb Inc"},{"name":"butorphanol","slug":"butorphanol","company":""},{"name":"caffeine","slug":"caffeine","company":"Novartis"}],"globalPrevalence":1500000000}],"mechanism":{"target":"Prostaglandin G/H synthase 1","targets":[{"gene":"PTGS1","source":"DrugCentral","target":"Prostaglandin G/H synthase 1","protein":"Prostaglandin G/H synthase 1"},{"gene":"PTGS2","source":"DrugCentral","target":"Prostaglandin G/H synthase 2","protein":"Prostaglandin G/H synthase 2"}],"modality":"Small Molecule","drugClass":"felbinac","explanation":"Imagine your body has a factory that produces chemicals called prostaglandins, which are like messengers that tell your brain that you're in pain. Traxam is like a factory worker who stops the production of these messengers, reducing the pain and inflammation. This helps to relieve the symptoms of osteoarthritis and pain.","oneSentence":"Traxam works by blocking the production of prostaglandins, hormone-like substances that cause pain and inflammation.","technicalDetail":"Traxam, a felbinac drug, selectively inhibits the activity of Prostaglandin G/H synthase 1 (PGHS-1), a key enzyme involved in the production of prostaglandins, thereby reducing the synthesis of prostaglandins and exerting its anti-inflammatory and analgesic effects."},"commercial":{},"references":[{"id":1,"url":"https://drugcentral.org/drugcard/1141","fields":["approvals","synonyms","ATC","PK","indications","contraindications","DDIs","targets","patents","FAERS"],"source":"DrugCentral"},{"id":2,"url":"https://clinicaltrials.gov/search?intr=FELBINAC","fields":["trials"],"source":"ClinicalTrials.gov"},{"id":3,"url":"https://pubmed.ncbi.nlm.nih.gov/?term=FELBINAC","fields":["publications"],"source":"PubMed/NCBI"}],"_enrichedAt":"2026-03-30T11:14:00.624505","biosimilars":[],"competitors":[{"drugName":"phenylbutazone","drugSlug":"phenylbutazone","fdaApproval":"1980-01-10","genericCount":6,"patentStatus":"Off-patent — generic available","relationship":"same-class"},{"drugName":"oxyphenbutazone","drugSlug":"oxyphenbutazone","fdaApproval":"1960-12-21","genericCount":1,"patentStatus":"Off-patent — generic available","relationship":"same-class"},{"drugName":"piroxicam","drugSlug":"piroxicam","fdaApproval":"1982-04-06","genericCount":18,"patentStatus":"Off-patent — generic available","relationship":"same-class"},{"drugName":"ketoprofen","drugSlug":"ketoprofen","fdaApproval":"1986-01-09","genericCount":7,"patentStatus":"Off-patent — generic available","relationship":"same-class"},{"drugName":"naproxen","drugSlug":"naproxen","fdaApproval":"1976-03-11","genericCount":31,"patentStatus":"Off-patent — generic available","relationship":"same-class"},{"drugName":"ibuprofen","drugSlug":"ibuprofen","fdaApproval":"1974-09-19","patentExpiry":"Sep 30, 2029","patentStatus":"Patent protected","relationship":"same-class"},{"drugName":"diclofenac","drugSlug":"diclofenac","fdaApproval":"1988-07-28","patentExpiry":"Apr 23, 2030","patentStatus":"Patent protected","relationship":"same-class"},{"drugName":"meclofenamic acid","drugSlug":"meclofenamic-acid","fdaApproval":"1980-06-25","relationship":"same-class"},{"drugName":"flurbiprofen","drugSlug":"flurbiprofen","fdaApproval":"1986-12-31","genericCount":8,"patentStatus":"Off-patent — generic available","relationship":"same-class"},{"drugName":"tolmetin","drugSlug":"tolmetin","fdaApproval":"1976-03-24","genericCount":6,"patentStatus":"Off-patent — generic available","relationship":"same-class"},{"drugName":"indomethacin","drugSlug":"indomethacin","fdaApproval":"1965-06-10","patentExpiry":"Apr 23, 2030","patentStatus":"Patent protected","relationship":"same-class"},{"drugName":"aceclofenac","drugSlug":"aceclofenac","fdaApproval":"","relationship":"same-class"}],"genericName":"felbinac","indications":{"approved":[{"name":"Osteoarthritis","source":"DrugCentral","snomedId":396275006,"regulator":"FDA","usPrevalence":null,"globalPrevalence":655000000,"prevalenceMethod":"curated","prevalenceSource":"Arthritis Res Ther, 2023 (PMID:36991481)"},{"name":"Pain","source":"DrugCentral","snomedId":22253000,"regulator":"FDA","usPrevalence":51600000,"globalPrevalence":1500000000,"prevalenceMethod":"curated","prevalenceSource":"CDC, 2023"}],"offLabel":[],"pipeline":[]},"drugCategory":"active","labelChanges":[],"relatedDrugs":[{"drugId":"phenylbutazone","brandName":"phenylbutazone","genericName":"phenylbutazone","approvalYear":"1980","relationship":"same-class"},{"drugId":"oxyphenbutazone","brandName":"oxyphenbutazone","genericName":"oxyphenbutazone","approvalYear":"1960","relationship":"same-class"},{"drugId":"piroxicam","brandName":"piroxicam","genericName":"piroxicam","approvalYear":"1982","relationship":"same-class"},{"drugId":"ketoprofen","brandName":"ketoprofen","genericName":"ketoprofen","approvalYear":"1986","relationship":"same-class"},{"drugId":"naproxen","brandName":"naproxen","genericName":"naproxen","approvalYear":"1976","relationship":"same-class"},{"drugId":"ibuprofen","brandName":"ibuprofen","genericName":"ibuprofen","approvalYear":"1974","relationship":"same-class"},{"drugId":"diclofenac","brandName":"diclofenac","genericName":"diclofenac","approvalYear":"1988","relationship":"same-class"},{"drugId":"meclofenamic-acid","brandName":"meclofenamic acid","genericName":"meclofenamic acid","approvalYear":"1980","relationship":"same-class"},{"drugId":"flurbiprofen","brandName":"flurbiprofen","genericName":"flurbiprofen","approvalYear":"1986","relationship":"same-class"},{"drugId":"tolmetin","brandName":"tolmetin","genericName":"tolmetin","approvalYear":"1976","relationship":"same-class"}],"trialDetails":[{"nctId":"NCT04526132","phase":"PHASE3","title":"A Phase Ⅲ Clinical Study Trial of Felbinac Trometamol Injection in China","status":"COMPLETED","sponsor":"Shijiazhuang Yiling Pharmaceutical Co. Ltd","startDate":"2021-04-25","conditions":["Pain"],"enrollment":306,"completionDate":"2022-06-30"},{"nctId":"NCT05297669","phase":"PHASE3","title":"A Phase # Clinical Study Trial of Felbinac Trometamol Injection in China","status":"COMPLETED","sponsor":"Shijiazhuang Yiling Pharmaceutical Co. Ltd","startDate":"2021-07-23","conditions":["Pain"],"enrollment":264,"completionDate":"2022-06-30"},{"nctId":"NCT05085106","phase":"PHASE1","title":"Safety, Tolerability and Pharmacokinetics of Felbinac Trometamol Eye Drops","status":"UNKNOWN","sponsor":"Beijing Tongren Hospital","startDate":"2020-10-21","conditions":["Healthy"],"enrollment":48,"completionDate":"2021-12-31"},{"nctId":"NCT03872830","phase":"PHASE2","title":"A Phase Ⅱ Clinical Study Trial of Felbinac Trometamol Injection in China","status":"COMPLETED","sponsor":"Shijiazhuang Yiling Pharmaceutical Co. Ltd","startDate":"2019-03-27","conditions":["Pain"],"enrollment":165,"completionDate":"2019-12-05"},{"nctId":"NCT03617510","phase":"PHASE1","title":"A Phase I Clinical Study Trial of Felbinac Trometamol Injection in China","status":"COMPLETED","sponsor":"Shijiazhuang Yiling Pharmaceutical Co. Ltd","startDate":"2018-07-10","conditions":["Pain"],"enrollment":48,"completionDate":"2019-04-30"},{"nctId":"NCT03235778","phase":"PHASE1","title":"A Phase I Clinical Study Trial of Felbinac Trometamol Injection in China","status":"COMPLETED","sponsor":"Yiling Pharmaceutical Inc.","startDate":"2017-07-17","conditions":["Healthy"],"enrollment":58,"completionDate":"2018-06-15"}],"genericFilers":[],"latestUpdates":[],"manufacturing":[],"crossReferences":{"NDDF":"003698","UNII":"94WNJ5U8L7","CHEBI":"CHEBI:31597","INN_ID":"5831","RXNORM":"225536","UMLSCUI":"C0877860","ChEMBL_ID":"CHEMBL413965","KEGG_DRUG":"D01675","DRUGBANK_ID":"DB07477","PDB_CHEM_ID":"BP4","PUBCHEM_CID":"3332","SNOMEDCT_US":"350320002","MESH_SUPPLEMENTAL_RECORD_UI":"C012776"},"formularyStatus":[],"_enricherVersion":"v2","developmentCodes":[],"ownershipHistory":[],"publicationCount":71,"therapeuticAreas":["Immunology"],"atcClassification":{"source":"DrugCentral","atcCode":"M02AA08","allCodes":["M02AA08"]},"biosimilarFilings":[],"recentPublications":[{"date":"2026 Mar 25","pmid":"41883118","title":"In vitro and preclinical assessment of drug interactions between fluoroquinolones and a non-steroidal anti-inflammatory drug predicting risk of seizure.","journal":"Toxicological sciences : an official journal of the Society of Toxicology"},{"date":"2026 Feb 9","pmid":"41754961","title":"In Vitro Evaluation of Poly(D,L-lactide-co-glycolide) In Situ Gels and Pharmacokinetics Following Subcutaneous Injection in Rats for Model Drugs.","journal":"Pharmaceutics"},{"date":"2025 Oct 4","pmid":"41044294","title":"A Novel Felbinac Transdermal Patch with High Permeability: Design, Development and Evaluation.","journal":"AAPS PharmSciTech"},{"date":"2024","pmid":"39077557","title":"Many human pharmaceuticals are weak inhibitors of the cytochrome P450 system in rainbow trout (Oncorhynchus mykiss) liver S9 fractions.","journal":"Frontiers in toxicology"},{"date":"2024 May 14","pmid":"38792157","title":"Experimental and Machine-Learning-Assisted Design of Pharmaceutically Acceptable Deep Eutectic Solvents for the Solubility Improvement of Non-Selective COX Inhibitors Ibuprofen and Ketoprofen.","journal":"Molecules (Basel, Switzerland)"}],"companionDiagnostics":[],"genericManufacturerList":[],"status":"active","companyName":"","companyId":"","modality":"Small molecule","firstApprovalDate":"","aiSummary":"Traxam, also known as Felbinac, is a small molecule drug that targets Prostaglandin G/H synthase 1. It is used to treat osteoarthritis and pain. The commercial status of Traxam is unclear, but it is classified as a felbinac drug class. As a non-steroidal anti-inflammatory drug (NSAID), Traxam works by inhibiting the production of prostaglandins, which are hormone-like substances that cause pain and inflammation.","enrichmentLevel":3,"visitCount":0,"trialStats":{"total":0,"withResults":0},"verificationStatus":"verified","dataCompleteness":{"mechanism":true,"indications":true,"safety":false,"trials":true,"score":3}}