{"id":"fecal-microbiota-transplant-with-pembrolizumab","safety":{"commonSideEffects":[{"rate":"null","effect":"Diarrhea"},{"rate":"null","effect":"Nausea"},{"rate":"null","effect":"Fatigue"}]},"_chembl":{"chemblId":"CHEMBL6068500","moleculeType":"Unknown"},"_dailymed":null,"mechanism":{"_ai_source":"groq-llama-8b","explanation":"Fecal microbiota transplant (FMT) involves transferring fecal matter from a healthy donor into a patient's gastrointestinal tract to restore a balanced gut microbiome. This can stimulate an anti-tumor immune response by increasing the expression of PD-L1 on tumor cells, thereby inhibiting the PD-1/PD-L1 pathway and enhancing T-cell activity against cancer cells.","oneSentence":"Fecal microbiota transplant modulates the gut microbiome to stimulate an anti-tumor immune response through PD-1/PD-L1 pathway.","_ai_confidence":"medium"},"_scrapedAt":"2026-03-28T01:53:46.410Z","_scrapedBy":"cloudflare-swarm","_wikipedia":null,"indications":{"approved":[{"name":"Melanoma"},{"name":"Non-small cell lung cancer"},{"name":"Head and neck squamous cell carcinoma"}]},"trialDetails":[{"nctId":"NCT05669846","phase":"PHASE2","title":"Study of Healthy Donor FMT (hdFMT) and Pembrolizumab in Relapsed/Refractory (R/R) PD-L1 Positive NSCLC","status":"RECRUITING","sponsor":"Diwakar Davar","startDate":"2025-01-08","conditions":"Non Small Cell Lung Cancer","enrollment":26},{"nctId":"NCT06030037","phase":"PHASE2","title":"Pembrolizumab/Lenvatinib With and Without Healthy Donor FMT (hdFMT) in Relapsed/ Refractory (R/R) Melanoma","status":"WITHDRAWN","sponsor":"Diwakar Davar","startDate":"2025-03-11","conditions":"PD-1 Refractory Advanced Melanoma","enrollment":""},{"nctId":"NCT03341143","phase":"PHASE2","title":"Fecal Microbiota Transplant (FMT) in Melanoma Patients","status":"COMPLETED","sponsor":"Zarour, Hassane, MD","startDate":"2018-03-19","conditions":"Melanoma","enrollment":20},{"nctId":"NCT04924374","phase":"NA","title":"Microbiota Transplant in Advanced Lung Cancer Treated With Immunotherapy","status":"COMPLETED","sponsor":"Fundacion para la Investigacion Biomedica del Hospital Universitario Ramon y Cajal","startDate":"2021-04-23","conditions":"Lung Cancer","enrollment":25},{"nctId":"NCT04951583","phase":"PHASE2","title":"Fecal Microbial Transplantation Non-Small Cell Lung Cancer and Melanoma","status":"ACTIVE_NOT_RECRUITING","sponsor":"Centre hospitalier de l'Université de Montréal (CHUM)","startDate":"2021-11-16","conditions":"Non Small Cell Lung Cancer Metastatic, Advanced Melanoma","enrollment":45},{"nctId":"NCT04116775","phase":"PHASE2","title":"Fecal Microbiota Transplant and Pembrolizumab for Men With Metastatic Castration Resistant Prostate Cancer.","status":"UNKNOWN","sponsor":"Julie Graff, MD","startDate":"2019-10-30","conditions":"Prostate Cancer, Prostate Cancer Metastatic","enrollment":32},{"nctId":"NCT05008861","phase":"PHASE1","title":"Gut Microbiota Reconstruction for NSCLC Immunotherapy","status":"UNKNOWN","sponsor":"Shanghai Zhongshan Hospital","startDate":"2021-09-01","conditions":"Non-Small Cell Lung Cancer","enrollment":20}],"_emaApprovals":[],"_faersSignals":[],"_approvalHistory":[],"publicationCount":0,"rwe":[],"genericFilers":[],"relatedDrugs":[],"labelChanges":[],"biosimilarFilings":[],"pricing":[],"formularyStatus":[],"manufacturing":[],"companionDiagnostics":[],"competitors":[],"timeline":[],"patents":[],"ownershipHistory":[],"trials":[],"biosimilars":[],"latestUpdates":[],"references":[],"tags":[],"ecosystem":[],"genericManufacturerList":[],"offLabel":[],"developmentCodes":[],"aliases":[],"phase":"phase_2","status":"active","brandName":"Fecal Microbiota Transplant with Pembrolizumab","genericName":"Fecal Microbiota Transplant with Pembrolizumab","companyName":"Zarour, Hassane, MD","companyId":"zarour-hassane-md","modality":"Small molecule","firstApprovalDate":"","aiSummary":"Fecal microbiota transplant modulates the gut microbiome to stimulate an anti-tumor immune response through PD-1/PD-L1 pathway. Used for Melanoma, Non-small cell lung cancer, Head and neck squamous cell carcinoma.","enrichmentLevel":3,"visitCount":1,"trialStats":{"total":1,"withResults":1},"verificationStatus":"verified","dataCompleteness":{"mechanism":true,"indications":true,"safety":true,"trials":true,"score":4}}