{"id":"febarbamate","rwe":[{"pmid":"11824432","year":"2001","title":"Severe hepatitis due to Atrium.","finding":"","journal":"Prescrire international","studyType":"Clinical Study"},{"pmid":"7761807","year":"1995","title":"[Acute liver failure following tetrabamate].","finding":"","journal":"Schweizerische medizinische Wochenschrift","studyType":"Clinical Study"},{"pmid":"7699230","year":"1994","title":"Possible association between poor metabolism of mephenytoin and hepatotoxicity caused by Atrium, a fixed combination preparation containing phenobarbital, febarbamate and difebarbamate.","finding":"","journal":"Journal of hepatology","studyType":"Clinical Study"},{"pmid":"8134787","year":"1993","title":"[Alcohol withdrawal syndrome and delirium tremens. 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FEBARBAMATE is like a traffic light that helps regulate the flow of information between different parts of the city, allowing it to function more smoothly. However, the exact way it does this is not yet fully understood.","oneSentence":"FEBARBAMATE is thought to work by modulating neurotransmitter activity in the brain.","technicalDetail":"FEBARBAMATE is a small molecule that interacts with unknown targets in the brain, potentially modulating the activity of neurotransmitters such as GABA or glutamate."},"commercial":{},"references":[{"id":1,"url":"https://drugcentral.org/drugcard/1135","fields":["approvals","synonyms","ATC","PK","indications","contraindications","DDIs","targets","patents","FAERS"],"source":"DrugCentral"},{"id":2,"url":"https://pubmed.ncbi.nlm.nih.gov/?term=FEBARBAMATE","fields":["publications"],"source":"PubMed/NCBI"}],"_enrichedAt":"2026-03-30T11:13:29.265744","_validation":{"fieldsValidated":0,"lastValidatedAt":"2026-04-20T11:07:51.250469+00:00","fieldsConflicting":0,"overallConfidence":0.95},"biosimilars":[],"competitors":[{"drugName":"carisoprodol","drugSlug":"carisoprodol","fdaApproval":"1959-04-09","genericCount":22,"patentStatus":"Off-patent — generic available","relationship":"same-class"},{"drugName":"methocarbamol","drugSlug":"methocarbamol","fdaApproval":"1957-07-16","patentExpiry":"Oct 9, 2044","patentStatus":"Patent protected","relationship":"same-class"}],"genericName":"febarbamate","indications":{"approved":[],"offLabel":[],"pipeline":[]},"drugCategory":"active","labelChanges":[],"relatedDrugs":[{"drugId":"carisoprodol","brandName":"carisoprodol","genericName":"carisoprodol","approvalYear":"1959","relationship":"same-class"},{"drugId":"methocarbamol","brandName":"methocarbamol","genericName":"methocarbamol","approvalYear":"1957","relationship":"same-class"}],"trialDetails":[],"genericFilers":[],"latestUpdates":[],"manufacturing":[],"crossReferences":{"NDDF":"005325","UNII":"5Z48ONN38P","CHEBI":"CHEBI:135655","INN_ID":"1243","RXNORM":"24807","UMLSCUI":"C0060130","ChEMBL_ID":"CHEMBL2104283","KEGG_DRUG":"D07275","DRUGBANK_ID":"DB13303","PUBCHEM_CID":"25803","MESH_SUPPLEMENTAL_RECORD_UI":"C003087"},"formularyStatus":[],"_enricherVersion":"v2","developmentCodes":[],"ownershipHistory":[],"publicationCount":11,"therapeuticAreas":["Neuroscience"],"atcClassification":{"source":"DrugCentral","atcCode":"M03BA05","allCodes":["M03BA05"]},"biosimilarFilings":[],"recentPublications":[{"date":"2001 Oct","pmid":"11824432","title":"Severe hepatitis due to Atrium.","journal":"Prescrire international"},{"date":"1995 May 13","pmid":"7761807","title":"[Acute liver failure following tetrabamate].","journal":"Schweizerische medizinische Wochenschrift"},{"date":"1994 Dec","pmid":"7699230","title":"Possible association between poor metabolism of mephenytoin and hepatotoxicity caused by Atrium, a fixed combination preparation containing phenobarbital, febarbamate and difebarbamate.","journal":"Journal of hepatology"},{"date":"1993 Oct 15","pmid":"8134787","title":"[Alcohol withdrawal syndrome and delirium tremens. 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