{"id":"febantel","rwe":[{"pmid":"40993797","year":"2025","title":"Field efficacy of Febantel, Pyrantel embonate and Praziquantel (Drontal® Tasty) against naturally acquired intestinal helminths of hunting dogs in southern Italy.","finding":"","journal":"Parasites & vectors","studyType":"Clinical Study"},{"pmid":"40795758","year":"2025","title":"Pharmacological evaluation on benzimidazole anthelmintics for eradication of the gill fluke Microcotyle sebastis infesting a black rockfish, Sebastes schlegelii.","finding":"","journal":"Veterinary parasitology","studyType":"Clinical Study"},{"pmid":"40671610","year":"2026","title":"In Vitro Anthelmintic Effect of Selected Agents Against Microcotyle sebastis and Microcotyle caudata, the Gill Monogenean Parasites of Rockfish, Sebastes spp.","finding":"","journal":"Journal of fish diseases","studyType":"Clinical Study"},{"pmid":"40596794","year":"2025","title":"Eucoleus boehmi in dogs: Anthelmintic treatment challenges and impact on olfactory capacity.","finding":"","journal":"Veterinary parasitology","studyType":"Clinical Study"},{"pmid":"40260210","year":"2025","title":"Bone marrow toxicity associated with febantel administration in a dog: Case Report.","finding":"","journal":"Frontiers in veterinary science","studyType":"Clinical Study"}],"tags":[{"label":"Small Molecule","category":"modality"},{"label":"Active","category":"status"},{"label":"Anthelmintics","category":"pharmacology"},{"label":"Anti-Infective Agents","category":"pharmacology"},{"label":"Antiparasitic Agents","category":"pharmacology"},{"label":"Antiprotozoal Agents","category":"pharmacology"}],"phase":"marketed","safety":{"commonSideEffects":[{"effect":"Vomiting","drugRate":"5%","severity":"common","organSystem":""},{"effect":"Bloody/mucoid stool","drugRate":"2.5%","severity":"common","organSystem":""},{"effect":"Watery/profuse stool","drugRate":"2.5%","severity":"common","organSystem":""}],"seriousAdverseEvents":[]},"trials":[],"aliases":[],"patents":[],"pricing":[],"_sources":{"trials":{"url":"https://clinicaltrials.gov/search?intr=FEBANTEL","method":"api_direct","source":"ClinicalTrials.gov","rawText":"","confidence":1,"sourceType":"ctgov","retrievedAt":"2026-04-20T01:06:01.190506+00:00"},"regulatory.ca":{"url":"","method":"api_direct","source":"Health Canada DPD","rawText":"","confidence":1,"sourceType":"health_canada_dpd","retrievedAt":"2026-04-20T01:06:10.020680+00:00"},"publicationCount":{"url":"https://pubmed.ncbi.nlm.nih.gov/?term=FEBANTEL","method":"api_direct","source":"PubMed/NCBI","rawText":"","confidence":1,"sourceType":"pubmed","retrievedAt":"2026-04-20T01:06:10.349893+00:00"},"crossReferences.chemblId":{"url":"https://www.ebi.ac.uk/chembl/compound_report_card/CHEMBL1080983/","method":"api_direct","source":"ChEMBL (EMBL-EBI)","rawText":"","confidence":1,"sourceType":"chembl","retrievedAt":"2026-04-20T01:06:11.132706+00:00"}},"allNames":"bay-vh-5757","offLabel":[],"synonyms":["febantel","BAY-VH-5757"],"timeline":[],"approvals":[{"date":"","orphan":false,"company":"","regulator":"FDA"}],"brandName":"Bay-Vh-5757","ecosystem":[],"mechanism":{"modality":"Small Molecule","explanation":"","oneSentence":"","technicalDetail":"FEBANTEL is a prodrug that is metabolized into its active form, which then inhibits the enzyme tyrosinase, disrupting the parasite's energy production and ultimately leading to its death."},"commercial":{},"references":[{"id":1,"url":"https://drugcentral.org/drugcard/5539","fields":["approvals","synonyms","ATC","PK","indications","contraindications","DDIs","targets","patents","FAERS"],"source":"DrugCentral"},{"id":2,"url":"https://pubmed.ncbi.nlm.nih.gov/?term=FEBANTEL","fields":["publications"],"source":"PubMed/NCBI"}],"_enrichedAt":"2026-03-30T13:44:03.218985","_validation":{"fieldsValidated":0,"lastValidatedAt":"2026-04-20T01:06:12.760951+00:00","fieldsConflicting":1,"overallConfidence":0.8},"biosimilars":[],"competitors":[],"genericName":"febantel","indications":{"approved":[],"offLabel":[],"pipeline":[]},"drugCategory":"active","labelChanges":[],"relatedDrugs":[],"trialDetails":[],"genericFilers":[],"latestUpdates":[],"manufacturing":[],"crossReferences":{"NDDF":"017763","UNII":"S75C401OS1","INN_ID":"4385","RXNORM":"24805","UMLSCUI":"C0060128","chemblId":"CHEMBL1080983","ChEMBL_ID":"CHEMBL1080983","KEGG_DRUG":"D04135","DRUGBANK_ID":"DB11409","PUBCHEM_CID":"135449328","SNOMEDCT_US":"96133002","MESH_SUPPLEMENTAL_RECORD_UI":"C017309"},"formularyStatus":[],"_enricherVersion":"v2","developmentCodes":[],"ownershipHistory":[],"publicationCount":141,"therapeuticAreas":["Metabolic"],"biosimilarFilings":[],"recentPublications":[{"date":"2025 Sep 24","pmid":"40993797","title":"Field efficacy of Febantel, Pyrantel embonate and Praziquantel (Drontal® Tasty) against naturally acquired intestinal helminths of hunting dogs in southern Italy.","journal":"Parasites & vectors"},{"date":"2025 Oct","pmid":"40795758","title":"Pharmacological evaluation on benzimidazole anthelmintics for eradication of the gill fluke Microcotyle sebastis infesting a black rockfish, Sebastes schlegelii.","journal":"Veterinary parasitology"},{"date":"2026 Feb","pmid":"40671610","title":"In Vitro Anthelmintic Effect of Selected Agents Against Microcotyle sebastis and Microcotyle caudata, the Gill Monogenean Parasites of Rockfish, Sebastes spp.","journal":"Journal of fish diseases"},{"date":"2025 Aug","pmid":"40596794","title":"Eucoleus boehmi in dogs: Anthelmintic treatment challenges and impact on olfactory capacity.","journal":"Veterinary parasitology"},{"date":"2025","pmid":"40260210","title":"Bone marrow toxicity associated with febantel administration in a dog: Case Report.","journal":"Frontiers in veterinary science"}],"companionDiagnostics":[],"genericManufacturerList":[],"status":"active","companyName":"","companyId":"","modality":"Small molecule","firstApprovalDate":"","aiSummary":"","enrichmentLevel":3,"visitCount":1,"regulatoryByCountry":[{"country_code":"US","regulator":"FDA","status":"approved","approval_date":null,"mah":"","brand_name_local":null,"application_number":""},{"country_code":"CA","regulator":"Health Canada","status":"approved","approval_date":null,"mah":"","brand_name_local":"","application_number":""},{"country_code":"BR","regulator":"ANVISA","status":"likely_approved","approval_date":null,"mah":null,"brand_name_local":null,"application_number":null},{"country_code":"MX","regulator":"COFEPRIS","status":"likely_approved","approval_date":null,"mah":null,"brand_name_local":null,"application_number":null},{"country_code":"AR","regulator":"ANMAT","status":"likely_approved","approval_date":null,"mah":null,"brand_name_local":null,"application_number":null},{"country_code":"TR","regulator":"TITCK","status":"likely_approved","approval_date":null,"mah":null,"brand_name_local":null,"application_number":null},{"country_code":"IN","regulator":"CDSCO","status":"likely_approved","approval_date":null,"mah":null,"brand_name_local":null,"application_number":null},{"country_code":"TH","regulator":"FDA-TH","status":"likely_approved","approval_date":null,"mah":null,"brand_name_local":null,"application_number":null},{"country_code":"MY","regulator":"NPRA","status":"likely_approved","approval_date":null,"mah":null,"brand_name_local":null,"application_number":null},{"country_code":"PH","regulator":"FDA-PH","status":"likely_approved","approval_date":null,"mah":null,"brand_name_local":null,"application_number":null},{"country_code":"CO","regulator":"INVIMA","status":"likely_approved","approval_date":null,"mah":null,"brand_name_local":null,"application_number":null},{"country_code":"ZA","regulator":"SAHPRA","status":"likely_approved","approval_date":null,"mah":null,"brand_name_local":null,"application_number":null},{"country_code":"TW","regulator":"TFDA","status":"likely_approved","approval_date":null,"mah":null,"brand_name_local":null,"application_number":null},{"country_code":"HK","regulator":"DH","status":"likely_approved","approval_date":null,"mah":null,"brand_name_local":null,"application_number":null},{"country_code":"IL","regulator":"MOH","status":"likely_approved","approval_date":null,"mah":null,"brand_name_local":null,"application_number":null},{"country_code":"SG","regulator":"HSA","status":"likely_approved","approval_date":null,"mah":null,"brand_name_local":null,"application_number":null},{"country_code":"AE","regulator":"MOH","status":"likely_approved","approval_date":null,"mah":null,"brand_name_local":null,"application_number":null},{"country_code":"KR","regulator":"MFDS","status":"likely_approved","approval_date":null,"mah":null,"brand_name_local":null,"application_number":null},{"country_code":"AU","regulator":"TGA","status":"likely_approved","approval_date":null,"mah":null,"brand_name_local":null,"application_number":null},{"country_code":"GB","regulator":"MHRA","status":"likely_approved","approval_date":null,"mah":null,"brand_name_local":null,"application_number":null}],"trialStats":{"total":0,"withResults":0},"validation":{"fieldsValidated":0,"lastValidatedAt":"2026-04-20T01:06:12.760951+00:00","fieldsConflicting":1,"overallConfidence":0.8},"verificationStatus":"enriching","dataCompleteness":{"mechanism":false,"indications":false,"safety":true,"trials":false,"score":1}}