{"id":"fazadinium","rwe":[{"pmid":"2682131","year":"1989","title":"Adverse reactions and interactions of the neuromuscular blocking drugs.","finding":"","journal":"Medical toxicology and adverse drug experience","studyType":"Clinical Study"},{"pmid":"2907392","year":"1988","title":"A clinical study on vecuronium in children: a comparison with fazadinium and pancuronium.","finding":"","journal":"The Turkish journal of pediatrics","studyType":"Clinical Study"},{"pmid":"2892234","year":"1987","title":"[Use of priming with fazadinium].","finding":"","journal":"Revista espanola de anestesiologia y reanimacion","studyType":"Clinical Study"},{"pmid":"2891159","year":"1987","title":"[Fazadinium and presynaptic effects].","finding":"","journal":"Revista espanola de anestesiologia y reanimacion","studyType":"Clinical Study"},{"pmid":"2889244","year":"1987","title":"[Electromyographic study of the effects of vecuronium bromide compared with those of pancuronium, tubocurarine, fazadinium and suxamethonium].","finding":"","journal":"Revista espanola de anestesiologia y reanimacion","studyType":"Clinical Study"}],"tags":[{"label":"fazadinium","category":"class"},{"label":"Small Molecule","category":"modality"},{"label":"M03AC08","category":"atc"},{"label":"Active","category":"status"}],"phase":"phase_2","safety":{},"trials":[],"aliases":[],"patents":[],"pricing":[],"allNames":"fazadon","offLabel":[],"synonyms":["fazadinium bromide","fazadon","fazadinium","fazadinium dibromide"],"timeline":[],"approvals":[],"brandName":"Fazadon","ecosystem":[],"mechanism":{"modality":"Small Molecule","drugClass":"fazadinium","explanation":"Think of acetylcholine like a messenger in your brain that helps you move and respond to the world around you. When acetylcholinesterase breaks it down, the message is lost. Fazadinium helps keep the message going by blocking the enzyme, allowing acetylcholine to stay active for longer.","oneSentence":"Fazadinium works by blocking the action of acetylcholinesterase, an enzyme that breaks down the neurotransmitter acetylcholine.","technicalDetail":"Fazadinium acts as a reversible inhibitor of acetylcholinesterase, competitively binding to the enzyme's active site and preventing the hydrolysis of acetylcholine into choline and acetic acid."},"commercial":{},"references":[{"id":1,"url":"https://drugcentral.org/drugcard/4535","fields":["approvals","synonyms","ATC","PK","indications","contraindications","DDIs","targets","patents","FAERS"],"source":"DrugCentral"},{"id":2,"url":"https://pubmed.ncbi.nlm.nih.gov/?term=FAZADINIUM","fields":["publications"],"source":"PubMed/NCBI"}],"_enrichedAt":"2026-03-30T11:13:22.861897","biosimilars":[],"competitors":[{"drugName":"pancuronium","drugSlug":"pancuronium","fdaApproval":"1972-10-24","genericCount":4,"patentStatus":"Off-patent — generic available","relationship":"same-class"},{"drugName":"gallamine","drugSlug":"gallamine","fdaApproval":"","patentStatus":"Unknown","relationship":"same-class"},{"drugName":"vecuronium","drugSlug":"vecuronium","fdaApproval":"1984-04-30","genericCount":9,"patentStatus":"Off-patent — generic available","relationship":"same-class"},{"drugName":"atracurium","drugSlug":"atracurium","fdaApproval":"1983-11-23","genericCount":11,"patentStatus":"Off-patent — generic available","relationship":"same-class"},{"drugName":"hexafluronium","drugSlug":"hexafluronium","fdaApproval":"","relationship":"same-class"},{"drugName":"pipecuronium","drugSlug":"pipecuronium","fdaApproval":"1990-06-26","patentStatus":"Unknown","relationship":"same-class"},{"drugName":"doxacurium","drugSlug":"doxacurium","fdaApproval":"1991-03-07","patentStatus":"Unknown","relationship":"same-class"},{"drugName":"rocuronium","drugSlug":"rocuronium","fdaApproval":"1994-03-17","patentExpiry":"Jul 22, 2039","patentStatus":"Patent protected","relationship":"same-class"},{"drugName":"mivacurium","drugSlug":"mivacurium","fdaApproval":"1992-01-22","genericCount":2,"patentStatus":"Off-patent — generic available","relationship":"same-class"},{"drugName":"cisatracurium","drugSlug":"cisatracurium","fdaApproval":"1995-12-15","genericCount":16,"patentStatus":"Off-patent — generic available","relationship":"same-class"}],"genericName":"fazadinium","indications":{"approved":[],"offLabel":[],"pipeline":[]},"drugCategory":"active","labelChanges":[],"relatedDrugs":[{"drugId":"pancuronium","brandName":"pancuronium","genericName":"pancuronium","approvalYear":"1972","relationship":"same-class"},{"drugId":"gallamine","brandName":"gallamine","genericName":"gallamine","approvalYear":"","relationship":"same-class"},{"drugId":"vecuronium","brandName":"vecuronium","genericName":"vecuronium","approvalYear":"1984","relationship":"same-class"},{"drugId":"atracurium","brandName":"atracurium","genericName":"atracurium","approvalYear":"1983","relationship":"same-class"},{"drugId":"hexafluronium","brandName":"hexafluronium","genericName":"hexafluronium","approvalYear":"","relationship":"same-class"},{"drugId":"pipecuronium","brandName":"pipecuronium","genericName":"pipecuronium","approvalYear":"1990","relationship":"same-class"},{"drugId":"doxacurium","brandName":"doxacurium","genericName":"doxacurium","approvalYear":"1991","relationship":"same-class"},{"drugId":"rocuronium","brandName":"rocuronium","genericName":"rocuronium","approvalYear":"1994","relationship":"same-class"},{"drugId":"mivacurium","brandName":"mivacurium","genericName":"mivacurium","approvalYear":"1992","relationship":"same-class"},{"drugId":"cisatracurium","brandName":"cisatracurium","genericName":"cisatracurium","approvalYear":"1995","relationship":"same-class"}],"trialDetails":[],"genericFilers":[],"latestUpdates":[],"manufacturing":[],"crossReferences":{"UNII":"0R97XIX3OA","CHEBI":"CHEBI:135984","INN_ID":"3678","UMLSCUI":"C0080352","ChEMBL_ID":"CHEMBL1739746","KEGG_DRUG":"D07273","DRUGBANK_ID":"DB13745","PUBCHEM_CID":"5487713","SECONDARY_CAS_RN":"49564-56-9","MESH_SUPPLEMENTAL_RECORD_UI":"C084773"},"formularyStatus":[],"_enricherVersion":"v2","developmentCodes":[],"ownershipHistory":[],"publicationCount":96,"therapeuticAreas":["Neuroscience"],"atcClassification":{"source":"DrugCentral","atcCode":"M03AC08","allCodes":["M03AC08"]},"biosimilarFilings":[],"recentPublications":[{"date":"1989 Sep-Oct","pmid":"2682131","title":"Adverse reactions and interactions of the neuromuscular blocking drugs.","journal":"Medical toxicology and adverse drug experience"},{"date":"1988 Jul-Sep","pmid":"2907392","title":"A clinical study on vecuronium in children: a comparison with fazadinium and pancuronium.","journal":"The Turkish journal of pediatrics"},{"date":"1987 Nov-Dec","pmid":"2892234","title":"[Use of priming with fazadinium].","journal":"Revista espanola de anestesiologia y reanimacion"},{"date":"1987 Sep-Oct","pmid":"2891159","title":"[Fazadinium and presynaptic effects].","journal":"Revista espanola de anestesiologia y reanimacion"},{"date":"1987 Jul-Aug","pmid":"2889244","title":"[Electromyographic study of the effects of vecuronium bromide compared with those of pancuronium, tubocurarine, fazadinium and suxamethonium].","journal":"Revista espanola de anestesiologia y reanimacion"}],"companionDiagnostics":[],"genericManufacturerList":[],"status":"active","companyName":"","companyId":"","modality":"Small molecule","firstApprovalDate":"","aiSummary":"Fazadon is a small molecule with the synonyms AH 8165D, AH-8165D, BROMURE DE FAZADINIUM, BROMURO DE FAZADINIO, FAZADINIUM BROMIDE, and FAZADINIUM BROMIDE.","enrichmentLevel":3,"visitCount":2,"trialStats":{"total":0,"withResults":0},"verificationStatus":"partial","dataCompleteness":{"mechanism":true,"indications":false,"safety":false,"trials":false,"score":1}}