{"id":"faropenem-medoxil","rwe":[],"tags":[{"label":"Small Molecule","category":"modality"},{"label":"Active","category":"status"},{"label":"Bacterial infection of skin","category":"indication"},{"label":"Respiratory tract infection","category":"indication"}],"phase":"unknown","safety":{},"trials":[],"aliases":[],"patents":[],"pricing":[],"allNames":"faropenem daloxate","offLabel":[],"synonyms":["faropenem medoxil","faropenem medoxomil","faropenem daloxate","BAY 56-6854","BAY 566854"],"timeline":[],"aiSummary":"Faropenem Daloxate is a small molecule inhibitor of bacterial penicillin-binding protein. It has been studied as a treatment for conditions such as otitis media and chronic bronchitis.","approvals":[],"brandName":"Faropenem Daloxate","ecosystem":[{"indication":"Bacterial infection of skin","otherDrugs":[{"name":"chloramphenicol","slug":"chloramphenicol","company":"Parkedale"},{"name":"dalbavancin","slug":"dalbavancin","company":"Durata Theraps Intl"},{"name":"delafloxacin","slug":"delafloxacin","company":"Melinta Therapeutics Inc"},{"name":"gentamicin","slug":"gentamicin","company":"Schering"}],"globalPrevalence":null},{"indication":"Respiratory tract infection","otherDrugs":[],"globalPrevalence":890552}],"mechanism":{"modality":"Small Molecule","explanation":"Imagine your body's cells are like houses, and bacteria are like unwanted guests. Faropenem Daloxate helps keep the guests from building new houses by blocking the tools they need to do so, ultimately leading to their demise.","oneSentence":"Faropenem Daloxate works by inhibiting bacterial cell wall synthesis.","technicalDetail":"Faropenem Daloxate is a beta-lactamase inhibitor that works by binding to penicillin-binding proteins (PBPs) on the bacterial cell wall, thereby inhibiting the cross-linking of peptidoglycan and ultimately leading to cell lysis and death."},"commercial":{},"references":[{"id":1,"url":"https://drugcentral.org/drugcard/5145","fields":["approvals","synonyms","ATC","PK","indications","contraindications","DDIs","targets","patents","FAERS"],"source":"DrugCentral"},{"id":2,"url":"https://clinicaltrials.gov/search?intr=faropenem%20medoxil","fields":["trials"],"source":"ClinicalTrials.gov"},{"id":3,"url":"https://pubmed.ncbi.nlm.nih.gov/?term=faropenem medoxil","fields":["publications"],"source":"PubMed/NCBI"}],"_enrichedAt":"2026-03-30T11:29:37.271256","biosimilars":[],"competitors":[],"genericName":"faropenem medoxil","indications":{"approved":[{"name":"Bacterial infection of skin","source":"DrugCentral","snomedId":128936008,"regulator":"FDA"},{"name":"Respiratory tract infection","source":"DrugCentral","snomedId":275498002,"regulator":"FDA","usPrevalence":null,"globalPrevalence":890552,"prevalenceMethod":"curated","prevalenceSource":"Orphanet (ORPHANET)"}],"offLabel":[],"pipeline":[]},"drugCategory":"active","labelChanges":[],"relatedDrugs":[],"trialDetails":[{"nctId":"NCT00255983","phase":"PHASE3","title":"A Trial to Evaluate the Efficacy and Safety of Faropenem Medoxomil In the Treatment of Chronic Bronchitis","status":"TERMINATED","sponsor":"Replidyne","startDate":"2005-12","conditions":["Chronic Bronchitis"],"enrollment":491,"completionDate":"2008-06"},{"nctId":"NCT00276042","phase":"PHASE2","title":"A Trial to Evaluate Faropenem Medoxomil in the Treatment of Acute Otitis Media","status":"COMPLETED","sponsor":"Replidyne","startDate":"2006-01","conditions":["Otitis Media"],"enrollment":328,"completionDate":""}],"genericFilers":[],"latestUpdates":[],"manufacturing":[],"crossReferences":{"UNII":"5OK523O4FU","CHEBI":"CHEBI:134710","UMLSCUI":"C1880735","ChEMBL_ID":"CHEMBL1257070","KEGG_DRUG":"D08919","DRUGBANK_ID":"DB05659","PUBCHEM_CID":"6918218","MESH_SUPPLEMENTAL_RECORD_UI":"C528565"},"formularyStatus":[],"_enricherVersion":"v2","developmentCodes":[],"ownershipHistory":[],"publicationCount":0,"therapeuticAreas":["Metabolic"],"biosimilarFilings":[],"recentPublications":[],"companionDiagnostics":[],"genericManufacturerList":[],"status":"active","companyName":"","companyId":"unknown","modality":"Small Molecule","firstApprovalDate":"","enrichmentLevel":3,"visitCount":0,"trialStats":{"total":0,"withResults":0},"verificationStatus":"verified","dataCompleteness":{"mechanism":true,"indications":true,"safety":false,"trials":true,"score":3}}