{"id":"famprofazone","rwe":[{"pmid":"35598557","year":"2022","title":"Determination of famprofazone, amphetamine and methamphetamine in liver samples using enzymatic cell dispersion and SPE-LC-ESI-MS.","finding":"","journal":"Journal of pharmaceutical and biomedical analysis","studyType":"Clinical Study"},{"pmid":"30262097","year":"2019","title":"Postmortem analysis of famprofazone and its metabolites, methamphetamine and amphetamine, in porcine bone marrow.","finding":"","journal":"Talanta","studyType":"Clinical Study"},{"pmid":"20663288","year":"2010","title":"Famprofazone use can be misinterpreted as methamphetamine abuse.","finding":"","journal":"Journal of analytical toxicology","studyType":"Clinical Study"},{"pmid":"17316255","year":"2007","title":"Famprofazone as the source of methamphetamine and amphetamine in urine specimen collected during sport competition.","finding":"","journal":"Journal of forensic sciences","studyType":"Clinical Study"},{"pmid":"15516292","year":"2004","title":"Metabolic profile of famprofazone following multidose administration.","finding":"","journal":"Journal of analytical toxicology","studyType":"Clinical Study"}],"tags":[{"label":"famprofazone","category":"class"},{"label":"Small Molecule","category":"modality"},{"label":"Nuclear receptor subfamily 2 group E member 1","category":"target"},{"label":"NR2E1","category":"gene"},{"label":"Active","category":"status"}],"phase":"phase_2","safety":{},"trials":[],"aliases":[],"patents":[],"pricing":[],"allNames":"gewodin","offLabel":[],"synonyms":["famprofazone","gewodin"],"timeline":[],"approvals":[],"brandName":"Gewodin","ecosystem":[],"mechanism":{"target":"Nuclear receptor subfamily 2 group E member 1","targets":[{"gene":"NR2E1","source":"DrugCentral","target":"Nuclear receptor subfamily 2 group E member 1","protein":"Nuclear receptor subfamily 2 group E member 1"}],"modality":"Small Molecule","drugClass":"famprofazone","explanation":"Imagine your cells have a special switch that controls how they work. Gewodin is like a key that fits into this switch, turning it on or off to affect how your cells behave. This can help with various health issues, but more research is needed to understand exactly how it works and what benefits it can provide.","oneSentence":"Gewodin works by binding to the nuclear receptor subfamily 2 group E member 1, influencing gene expression and cellular processes.","technicalDetail":"Famprofazone acts as a ligand for the PPARγ (peroxisome proliferator-activated receptor gamma) nuclear receptor, modulating gene expression and influencing various cellular processes."},"commercial":{},"references":[{"id":1,"url":"https://drugcentral.org/drugcard/1130","fields":["approvals","synonyms","ATC","PK","indications","contraindications","DDIs","targets","patents","FAERS"],"source":"DrugCentral"},{"id":2,"url":"https://pubmed.ncbi.nlm.nih.gov/?term=FAMPROFAZONE","fields":["publications"],"source":"PubMed/NCBI"}],"_enrichedAt":"2026-03-30T11:12:58.693763","biosimilars":[],"competitors":[{"drugName":"dydrogesterone","drugSlug":"dydrogesterone","fdaApproval":"","patentStatus":"Unknown","relationship":"same-target"},{"drugName":"propafenone","drugSlug":"propafenone","fdaApproval":"1989-11-27","genericCount":15,"patentStatus":"Off-patent — generic available","relationship":"same-target"},{"drugName":"propranolol","drugSlug":"propranolol","fdaApproval":"1967-11-13","patentExpiry":"Oct 16, 2028","patentStatus":"Patent protected","relationship":"same-target"},{"drugName":"tadalafil","drugSlug":"tadalafil","fdaApproval":"2003-11-21","patentExpiry":"Dec 24, 2038","patentStatus":"Patent protected","relationship":"same-target"},{"drugName":"tretinoin","drugSlug":"tretinoin","fdaApproval":"1971-10-20","patentExpiry":"Aug 22, 2038","patentStatus":"Patent protected","relationship":"same-target"}],"dataSources":[{"url":"https://drugcentral.org","name":"DrugCentral","fields":["indications","contraindications","safety","target","drugInteractions"],"retrievedDate":"2026-04-07"}],"genericName":"famprofazone","indications":{"approved":[],"offLabel":[],"pipeline":[]},"drugCategory":"active","labelChanges":[],"relatedDrugs":[{"drugId":"dydrogesterone","brandName":"dydrogesterone","genericName":"dydrogesterone","approvalYear":"","relationship":"same-target"},{"drugId":"propafenone","brandName":"propafenone","genericName":"propafenone","approvalYear":"1989","relationship":"same-target"},{"drugId":"propranolol","brandName":"propranolol","genericName":"propranolol","approvalYear":"1967","relationship":"same-target"},{"drugId":"tadalafil","brandName":"tadalafil","genericName":"tadalafil","approvalYear":"2003","relationship":"same-target"},{"drugId":"tretinoin","brandName":"tretinoin","genericName":"tretinoin","approvalYear":"1971","relationship":"same-target"}],"trialDetails":[],"genericFilers":[],"latestUpdates":[],"manufacturing":[],"administration":{},"crossReferences":{"NDDF":"007128","UNII":"HN0NCX453C","CHEBI":"CHEBI:135587","INN_ID":"2645","UMLSCUI":"C0170987","ChEMBL_ID":"CHEMBL1475693","DRUGBANK_ID":"DB16702","PUBCHEM_CID":"3326","MESH_SUPPLEMENTAL_RECORD_UI":"C076013"},"formularyStatus":[],"_enricherVersion":"v2","developmentCodes":[],"ownershipHistory":[],"publicationCount":19,"therapeuticAreas":["Other"],"biosimilarFilings":[],"recentPublications":[{"date":"2022 Aug 5","pmid":"35598557","title":"Determination of famprofazone, amphetamine and methamphetamine in liver samples using enzymatic cell dispersion and SPE-LC-ESI-MS.","journal":"Journal of pharmaceutical and biomedical analysis"},{"date":"2019 Jan 1","pmid":"30262097","title":"Postmortem analysis of famprofazone and its metabolites, methamphetamine and amphetamine, in porcine bone marrow.","journal":"Talanta"},{"date":"2010 Jul-Aug","pmid":"20663288","title":"Famprofazone use can be misinterpreted as methamphetamine abuse.","journal":"Journal of analytical toxicology"},{"date":"2007 Mar","pmid":"17316255","title":"Famprofazone as the source of methamphetamine and amphetamine in urine specimen collected during sport competition.","journal":"Journal of forensic sciences"},{"date":"2004 Sep","pmid":"15516292","title":"Metabolic profile of famprofazone following multidose administration.","journal":"Journal of analytical toxicology"}],"companionDiagnostics":[],"genericManufacturerList":[],"status":"active","companyName":"","companyId":"","modality":"Small molecule","firstApprovalDate":"","aiSummary":"Gewodin, also known as famprofazone, is a small molecule drug that targets the nuclear receptor subfamily 2 group E member 1. Its exact commercial status is unknown, but it is classified as a famprofazone drug class. Gewodin's mechanism of action and approved indications are not well-documented, and it has not received FDA approval. Further research is needed to understand its potential therapeutic applications and safety considerations.","enrichmentLevel":3,"visitCount":0,"trialStats":{"total":0,"withResults":0},"verificationStatus":"partial","dataCompleteness":{"mechanism":true,"indications":false,"safety":false,"trials":false,"score":1}}