{"id":"fadrozole","rwe":[],"tags":[{"label":"fadrozole","category":"class"},{"label":"Small Molecule","category":"modality"},{"label":"Aromatase","category":"target"},{"label":"CYP19A1","category":"gene"},{"label":"CYP11B2","category":"gene"},{"label":"CYP11B1","category":"gene"},{"label":"Active","category":"status"},{"label":"Antineoplastic Agents","category":"pharmacology"},{"label":"Antineoplastic Agents, Hormonal","category":"pharmacology"},{"label":"Aromatase Inhibitors","category":"pharmacology"},{"label":"Enzyme Inhibitors","category":"pharmacology"},{"label":"Estrogen Antagonists","category":"pharmacology"},{"label":"Hormone Antagonists","category":"pharmacology"},{"label":"Steroid Synthesis Inhibitors","category":"pharmacology"}],"phase":"phase_2","safety":{},"trials":[],"aliases":[],"patents":[],"pricing":[],"allNames":["fadrozole","fadrozole hydrochloride","fadrozole HCl","fadrozole monohydrochloride","CGS 16949A","CGS-16949A"],"offLabel":[],"synonyms":["fadrozole","fadrozole hydrochloride","fadrozole HCl","fadrozole monohydrochloride","CGS 16949A","CGS-16949A"],"timeline":[],"aiSummary":"Fadrozole is a small molecule drug that targets aromatase, an enzyme involved in estrogen production. It is classified as a fadrozole, a type of non-steroidal aromatase inhibitor. Fadrozole's commercial status and approved indications are unknown. As a result, its safety profile and pharmacokinetic properties, such as half-life and bioavailability, are also unclear. Further research is needed to determine its potential therapeutic applications.","approvals":[],"ecosystem":[],"mechanism":{"target":"Cytochrome P450 11B2, mitochondrial, Aromatase, Cytochrome P450 11B1, mitochondrial","targets":[{"gene":"CYP19A1","source":"DrugCentral","target":"Aromatase","protein":"Aromatase"},{"gene":"CYP11B2","source":"DrugCentral","target":"Cytochrome P450 11B2, mitochondrial","protein":"Cytochrome P450 11B2, mitochondrial"},{"gene":"CYP11B1","source":"DrugCentral","target":"Cytochrome P450 11B1, mitochondrial","protein":"Cytochrome P450 11B1, mitochondrial"}],"modality":"Small Molecule","drugClass":"fadrozole","explanation":"Think of aromatase like a translator that helps turn male hormones into female hormones. By blocking this translator, fadrozole reduces the amount of estrogen in the body. This can be beneficial in certain medical conditions where estrogen levels are too high.","oneSentence":"Fadrozole works by blocking the aromatase enzyme, which is responsible for converting androgens into estrogens.","technicalDetail":"Fadrozole inhibits the activity of aromatase (CYP19A1) through competitive binding to the enzyme's active site, thereby reducing the conversion of androstenedione and testosterone to estrone and estradiol."},"commercial":{},"references":[{"id":1,"url":"https://drugcentral.org/drugcard/1126","fields":["approvals","synonyms","ATC","PK","indications","contraindications","DDIs","targets","patents","FAERS"],"source":"DrugCentral"},{"id":2,"url":"https://pubmed.ncbi.nlm.nih.gov/?term=FADROZOLE","fields":["publications"],"source":"PubMed/NCBI"}],"_enrichedAt":"2026-03-30T11:29:31.787602","biosimilars":[],"competitors":[{"drugName":"abiraterone acetate","drugSlug":"abiraterone-acetate","fdaApproval":"2011-04-28","patentExpiry":"May 20, 2034","patentStatus":"Patent protected","relationship":"same-target"},{"drugName":"etomidate","drugSlug":"etomidate","fdaApproval":"1982-09-07","genericCount":10,"patentStatus":"Off-patent — generic available","relationship":"same-target"},{"drugName":"ketoconazole","drugSlug":"ketoconazole","fdaApproval":"1981-06-12","genericCount":19,"patentStatus":"Off-patent — generic available","relationship":"same-target"},{"drugName":"letrozole","drugSlug":"letrozole","fdaApproval":"1997-07-25","genericCount":19,"patentStatus":"Off-patent — generic available","relationship":"same-target"},{"drugName":"metyrapone","drugSlug":"metyrapone","fdaApproval":"1961-12-04","patentStatus":"Unknown","relationship":"same-target"},{"drugName":"mitotane","drugSlug":"mitotane","fdaApproval":"1970-07-08","patentStatus":"Unknown","relationship":"same-target"},{"drugName":"osilodrostat","drugSlug":"osilodrostat","fdaApproval":"2020-03-06","patentExpiry":"Oct 12, 2035","patentStatus":"Patent protected","relationship":"same-target"}],"dataSources":[{"url":"https://drugcentral.org","name":"DrugCentral","fields":["indications","contraindications","safety","target","drugInteractions"],"retrievedDate":"2026-04-07"}],"genericName":"fadrozole","indications":{"approved":[],"offLabel":[],"pipeline":[]},"drugCategory":"active","labelChanges":[],"relatedDrugs":[{"drugId":"abiraterone-acetate","brandName":"abiraterone acetate","genericName":"abiraterone acetate","approvalYear":"2011","relationship":"same-target"},{"drugId":"etomidate","brandName":"etomidate","genericName":"etomidate","approvalYear":"1982","relationship":"same-target"},{"drugId":"ketoconazole","brandName":"ketoconazole","genericName":"ketoconazole","approvalYear":"1981","relationship":"same-target"},{"drugId":"letrozole","brandName":"letrozole","genericName":"letrozole","approvalYear":"1997","relationship":"same-target"},{"drugId":"metyrapone","brandName":"metyrapone","genericName":"metyrapone","approvalYear":"1961","relationship":"same-target"},{"drugId":"mitotane","brandName":"mitotane","genericName":"mitotane","approvalYear":"1970","relationship":"same-target"},{"drugId":"osilodrostat","brandName":"osilodrostat","genericName":"osilodrostat","approvalYear":"2020","relationship":"same-target"}],"trialDetails":[],"genericFilers":[],"latestUpdates":[],"manufacturing":[],"administration":{},"crossReferences":{"UNII":"H3988M64PU","CHEBI":"CHEBI:31589","INN_ID":"6632","UMLSCUI":"C0117234","ChEMBL_ID":"CHEMBL9298","KEGG_DRUG":"D02451","DRUGBANK_ID":"DB16832","PDB_CHEM_ID":" 0T3","PUBCHEM_CID":"59693","IUPHAR_LIGAND_ID":"8311","SECONDARY_CAS_RN":"102676-31-3","MESH_DESCRIPTOR_UI":"D017316"},"formularyStatus":[],"_enricherVersion":"v2","developmentCodes":[],"ownershipHistory":[],"publicationCount":0,"therapeuticAreas":["Other"],"biosimilarFilings":[],"recentPublications":[],"companionDiagnostics":[],"genericManufacturerList":[],"status":"active","brandName":"FADROZOLE","companyName":"","companyId":"","modality":"Small molecule","firstApprovalDate":"","enrichmentLevel":3,"visitCount":0,"trialStats":{"total":0,"withResults":0},"verificationStatus":"partial","dataCompleteness":{"mechanism":true,"indications":false,"safety":false,"trials":false,"score":1}}