{"id":"f-pf-004390-eye-drops","safety":{"commonSideEffects":[{"rate":null,"effect":"Dysgeusia (taste disturbance)"},{"rate":null,"effect":"Eye irritation"},{"rate":null,"effect":"Conjunctival hyperemia"}]},"_chembl":null,"_dailymed":null,"mechanism":{"_ai_source":"claude-haiku-4.5","explanation":"TRPM8 (Transient Receptor Potential Melastatin 8) is a cold-sensing ion channel expressed on sensory nerve fibers in the cornea and conjunctiva. By antagonizing TRPM8, PF-004390 reduces neuropathic signaling associated with dry eye disease and ocular surface pain, providing symptomatic relief without affecting tear production or other ocular functions.","oneSentence":"PF-004390 is a selective TRPM8 antagonist that blocks cold-sensing ion channels in the eye to reduce ocular pain and discomfort.","_ai_confidence":"medium"},"_scrapedAt":"2026-03-28T01:12:14.137Z","_scrapedBy":"cloudflare-swarm","_wikipedia":null,"indications":{"approved":[{"name":"Dry eye disease (ocular surface pain)"}]},"trialDetails":[{"nctId":"NCT03198000","phase":"PHASE3","title":"A Study to Evaluate the Efficacy of Investigational OTC Eye Drops","status":"COMPLETED","sponsor":"Johnson & Johnson Consumer Inc. (J&JCI)","startDate":"2017-06-28","conditions":"Ophthalmic Solutions","enrollment":120}],"_emaApprovals":[],"_faersSignals":[],"_approvalHistory":[],"publicationCount":280,"rwe":[],"genericFilers":[],"relatedDrugs":[],"labelChanges":[],"biosimilarFilings":[],"pricing":[],"formularyStatus":[],"manufacturing":[],"companionDiagnostics":[],"competitors":[],"timeline":[],"patents":[],"ownershipHistory":[],"trials":[],"biosimilars":[],"latestUpdates":[],"references":[],"tags":[],"ecosystem":[],"genericManufacturerList":[],"offLabel":[],"developmentCodes":[],"aliases":[],"phase":"phase_3","status":"active","brandName":"F# PF-004390 Eye Drops","genericName":"F# PF-004390 Eye Drops","companyName":"Johnson & Johnson Consumer Inc. (J&JCI)","companyId":"johnson-johnson-consumer-inc-j-jci","modality":"Small molecule","firstApprovalDate":"","aiSummary":"PF-004390 is a selective TRPM8 antagonist that blocks cold-sensing ion channels in the eye to reduce ocular pain and discomfort. Used for Dry eye disease (ocular surface pain).","enrichmentLevel":3,"visitCount":0,"trialStats":{"total":1,"withResults":1},"verificationStatus":"verified","dataCompleteness":{"mechanism":true,"indications":true,"safety":true,"trials":true,"score":4}}