{"id":"f-18-fpcit","safety":{"commonSideEffects":[{"rate":null,"effect":"Radiation exposure"}]},"_chembl":null,"_dailymed":null,"mechanism":{"_ai_source":"claude-haiku-4.5","explanation":"F-18 FPCIT is a positron emission tomography (PET) radiopharmaceutical that selectively binds to dopamine transporters located on presynaptic dopaminergic neurons. By measuring the uptake and distribution of this tracer in the striatum, clinicians can assess the density and function of dopaminergic neurons, enabling differentiation of neurodegenerative parkinsonian syndromes and detection of dopaminergic dysfunction.","oneSentence":"F-18 FPCIT is a fluorine-18 labeled dopamine transporter (DAT) imaging agent that binds to dopamine transporters in the striatum to visualize dopaminergic neuronal integrity via PET imaging.","_ai_confidence":"medium"},"_scrapedAt":"2026-03-28T00:46:40.037Z","_scrapedBy":"cloudflare-swarm","_wikipedia":null,"indications":{"approved":[{"name":"Imaging of dopamine transporters in the striatum to aid in the diagnosis of Parkinson's disease and differentiation from essential tremor and other parkinsonian syndromes"}]},"trialDetails":[{"nctId":"NCT00468078","phase":"PHASE3","title":"Efficacy and Safety of F-18 FPCIT PET in Parkinson's Disease and Essential Tremor Patients","status":"COMPLETED","sponsor":"Asan Medical Center","startDate":"2006-11","conditions":"Parkinson's Disease","enrollment":78}],"_emaApprovals":[],"_faersSignals":[],"_approvalHistory":[],"publicationCount":25,"rwe":[],"genericFilers":[],"relatedDrugs":[],"labelChanges":[],"biosimilarFilings":[],"pricing":[],"formularyStatus":[],"manufacturing":[],"companionDiagnostics":[],"competitors":[],"timeline":[],"patents":[],"ownershipHistory":[],"trials":[],"biosimilars":[],"latestUpdates":[],"references":[],"tags":[],"ecosystem":[],"genericManufacturerList":[],"offLabel":[],"developmentCodes":[],"aliases":[],"phase":"phase_3","status":"active","brandName":"F-18 FPCIT","genericName":"F-18 FPCIT","companyName":"Asan Medical Center","companyId":"asan-medical-center","modality":"Small molecule","firstApprovalDate":"","aiSummary":"F-18 FPCIT is a fluorine-18 labeled dopamine transporter (DAT) imaging agent that binds to dopamine transporters in the striatum to visualize dopaminergic neuronal integrity via PET imaging. Used for Imaging of dopamine transporters in the striatum to aid in the diagnosis of Parkinson's disease and differentiation from essential tremor and other parkinsonian syndromes.","enrichmentLevel":3,"visitCount":1,"trialStats":{"total":0,"withResults":0},"verificationStatus":"verified","dataCompleteness":{"mechanism":true,"indications":true,"safety":true,"trials":true,"score":4}}