{"id":"eye-drops-phenylephrin","safety":{"commonSideEffects":[{"rate":null,"effect":"Ocular irritation"},{"rate":null,"effect":"Transient stinging or burning"},{"rate":null,"effect":"Blurred vision"},{"rate":null,"effect":"Systemic hypertension (with systemic absorption)"}]},"_chembl":null,"_dailymed":null,"mechanism":{"_ai_source":"claude-haiku-4.5","explanation":"Phenylephrine works by stimulating alpha-1 adrenergic receptors on vascular smooth muscle in the conjunctiva and iris, causing vasoconstriction that reduces conjunctival hyperemia and mydriasis (pupil dilation). In ophthalmic formulations, it is used as a decongestant to relieve eye redness and as a mydriatic agent for diagnostic procedures.","oneSentence":"Phenylephrine is an alpha-1 adrenergic agonist that constricts blood vessels in the eye to reduce redness and dilate the pupil.","_ai_confidence":"high"},"_scrapedAt":"2026-03-27T23:46:10.735Z","_scrapedBy":"cloudflare-swarm","_wikipedia":null,"indications":{"approved":[{"name":"Conjunctival hyperemia (eye redness)"},{"name":"Mydriasis for diagnostic procedures"}]},"trialDetails":[{"nctId":"NCT04880928","phase":"PHASE4","title":"Comparison Mydriasis by Mydrane With Topical Drop Application","status":"COMPLETED","sponsor":"Medical University of Graz","startDate":"2020-08-12","conditions":"Cataract","enrollment":42}],"_emaApprovals":[],"_faersSignals":[],"_approvalHistory":[],"publicationCount":0,"rwe":[],"genericFilers":[],"relatedDrugs":[],"labelChanges":[],"biosimilarFilings":[],"pricing":[],"formularyStatus":[],"manufacturing":[],"companionDiagnostics":[],"competitors":[],"timeline":[],"patents":[],"ownershipHistory":[],"trials":[],"biosimilars":[],"latestUpdates":[],"references":[],"tags":[],"ecosystem":[],"genericManufacturerList":[],"offLabel":[],"developmentCodes":[],"aliases":["Minims"],"phase":"marketed","status":"active","brandName":"eye drops (Phenylephrin)","genericName":"eye drops (Phenylephrin)","companyName":"Medical University of Graz","companyId":"medical-university-of-graz","modality":"Small molecule","firstApprovalDate":"","aiSummary":"Phenylephrine is an alpha-1 adrenergic agonist that constricts blood vessels in the eye to reduce redness and dilate the pupil. Used for Conjunctival hyperemia (eye redness), Mydriasis for diagnostic procedures.","enrichmentLevel":3,"visitCount":1,"trialStats":{"total":0,"withResults":0},"verificationStatus":"verified","dataCompleteness":{"mechanism":true,"indications":true,"safety":true,"trials":true,"score":4}}