{"id":"extract-of-agaricus-blazei-murill","safety":{"commonSideEffects":[{"rate":null,"effect":"Gastrointestinal disturbance"},{"rate":null,"effect":"Allergic reactions"},{"rate":null,"effect":"Fever"}]},"_chembl":{"chemblId":"CHEMBL2074772","moleculeType":"Unknown"},"_dailymed":null,"mechanism":{"_ai_source":"claude-haiku-4.5","explanation":"The extract contains bioactive polysaccharides, particularly beta-glucans, which are recognized by pattern recognition receptors on immune cells. These components stimulate macrophage activation, increase cytokine production (IL-2, TNF-α, IFN-γ), and enhance natural killer cell activity, thereby potentiating anti-tumor and immunomodulatory effects. The mechanism is primarily immunostimulatory rather than direct cytotoxic.","oneSentence":"Agaricus blazei Murill extract enhances immune function through polysaccharide and beta-glucan components that activate macrophages, natural killer cells, and other innate immune cells.","_ai_confidence":"medium"},"_scrapedAt":"2026-03-28T01:12:05.764Z","_scrapedBy":"cloudflare-swarm","_wikipedia":null,"indications":{"approved":[{"name":"Cancer (various types, under investigation in Phase 3)"},{"name":"Immune support and immunomodulation"}]},"trialDetails":[{"nctId":"NCT06599710","phase":"NA","title":"The Effects of a Food Product Containing Mushroom Extracts (AndoSanTM) in Subjects with Colorectal Cancer-related Fatigue","status":"RECRUITING","sponsor":"Mycotech Pharma AS","startDate":"2024-09-09","conditions":"Cancer-related Fatigue","enrollment":30},{"nctId":"NCT05192720","phase":"NA","title":"Andosan in Allergic and Asthma Patients","status":"COMPLETED","sponsor":"University Hospital, Akershus","startDate":"2021-08-31","conditions":"Allergic Asthma, Allergic Rhinoconjunctivitis, Immune Tolerance","enrollment":34},{"nctId":"NCT01496053","phase":"PHASE2, PHASE3","title":"Anti-inflammatory Effect of Agaricus Blazei Murill in Inflammatory Bowel Disease (IBD)","status":"COMPLETED","sponsor":"Oslo University Hospital","startDate":"2011-12","conditions":"Ulcerative Colitis, Crohn's Disease, Inflammatory Bowel Disease","enrollment":100},{"nctId":"NCT00970021","phase":"PHASE2","title":"Agaricus Blazei Murill in Patients With Multiple Myeloma","status":"COMPLETED","sponsor":"Ullevaal University Hospital","startDate":"2009-06","conditions":"Multiple Myeloma","enrollment":39},{"nctId":"NCT01106742","phase":"PHASE2","title":"Agaricus Blazei Murill (ABM) in Patients With Inflammatory Bowel Disease (IBD)","status":"COMPLETED","sponsor":"Ullevaal University Hospital","startDate":"2009-03","conditions":"Inflammatory Bowel Disease","enrollment":20},{"nctId":"NCT00131287","phase":"PHASE3","title":"The Supplementary Effects of the Extract of Agaricus Blazei Murril on Type II Diabetes Mellitus (DM)","status":"COMPLETED","sponsor":"ECbiotech Taiwan","startDate":"2005-07","conditions":"Diabetes Mellitus, Type II","enrollment":108}],"_emaApprovals":[],"_faersSignals":[],"_approvalHistory":[],"publicationCount":101,"rwe":[],"genericFilers":[],"relatedDrugs":[],"labelChanges":[],"biosimilarFilings":[],"pricing":[],"formularyStatus":[],"manufacturing":[],"companionDiagnostics":[],"competitors":[],"timeline":[],"patents":[],"ownershipHistory":[],"trials":[],"biosimilars":[],"latestUpdates":[],"references":[],"tags":[],"ecosystem":[],"genericManufacturerList":[],"offLabel":[],"developmentCodes":[],"aliases":[],"phase":"phase_3","status":"active","brandName":"Extract of Agaricus blazei Murill","genericName":"Extract of Agaricus blazei Murill","companyName":"ECbiotech Taiwan","companyId":"ecbiotech-taiwan","modality":"Small molecule","firstApprovalDate":"","aiSummary":"Agaricus blazei Murill extract enhances immune function through polysaccharide and beta-glucan components that activate macrophages, natural killer cells, and other innate immune cells. Used for Cancer (various types, under investigation in Phase 3), Immune support and immunomodulation.","enrichmentLevel":3,"visitCount":1,"trialStats":{"total":0,"withResults":0},"verificationStatus":"verified","dataCompleteness":{"mechanism":true,"indications":true,"safety":true,"trials":true,"score":4}}