{"id":"extract-from-hintonia-latiflora-bark","safety":{"commonSideEffects":[{"rate":null,"effect":"Gastrointestinal disturbances"},{"rate":null,"effect":"Dizziness"},{"rate":null,"effect":"Cardiac conduction abnormalities"}]},"_chembl":{"chemblId":"CHEMBL2074772","moleculeType":"Unknown"},"_dailymed":null,"mechanism":{"_ai_source":"claude-haiku-4.5","explanation":"The bark extract from Hintonia latiflora (also known as Curtisia dentata) has been traditionally used and studied for cardiac rhythm regulation. The active alkaloid components, particularly those with quinidine-like properties, modulate cardiac conduction and refractoriness, helping to stabilize abnormal heart rhythms. The mechanism involves effects on cardiac ion channels and membrane stabilization.","oneSentence":"Hintonia latiflora bark extract contains alkaloids that act as antiarrhythmic agents, primarily through cardiac electrophysiological effects.","_ai_confidence":"low"},"_scrapedAt":"2026-03-28T01:12:06.298Z","_scrapedBy":"cloudflare-swarm","_wikipedia":null,"indications":{"approved":[{"name":"Cardiac arrhythmias"},{"name":"Atrial fibrillation"}]},"trialDetails":[{"nctId":"NCT00315718","phase":"PHASE3","title":"Long-Term Effects of Sucontral(TM) on Mild and Moderate Cases of Diabetes Mellitus (Type 2)","status":"COMPLETED","sponsor":"Harras Pharma Curarina GmbH","startDate":"2002-06","conditions":"Diabetes Mellitus, Type 2","enrollment":10}],"_emaApprovals":[],"_faersSignals":[],"_approvalHistory":[],"publicationCount":1,"rwe":[],"genericFilers":[],"relatedDrugs":[],"labelChanges":[],"biosimilarFilings":[],"pricing":[],"formularyStatus":[],"manufacturing":[],"companionDiagnostics":[],"competitors":[],"timeline":[],"patents":[],"ownershipHistory":[],"trials":[],"biosimilars":[],"latestUpdates":[],"references":[],"tags":[],"ecosystem":[],"genericManufacturerList":[],"offLabel":[],"developmentCodes":[],"aliases":[],"phase":"phase_3","status":"active","brandName":"Extract from Hintonia latiflora bark","genericName":"Extract from Hintonia latiflora bark","companyName":"Harras Pharma Curarina GmbH","companyId":"harras-pharma-curarina-gmbh","modality":"Small molecule","firstApprovalDate":"","aiSummary":"Hintonia latiflora bark extract contains alkaloids that act as antiarrhythmic agents, primarily through cardiac electrophysiological effects. Used for Cardiac arrhythmias, Atrial fibrillation.","enrichmentLevel":3,"visitCount":1,"trialStats":{"total":0,"withResults":0},"verificationStatus":"verified","dataCompleteness":{"mechanism":true,"indications":true,"safety":true,"trials":true,"score":4}}