{"id":"extraarticular-injection-with-ropivacaine","safety":{"commonSideEffects":[{"rate":null,"effect":"Injection site pain or discomfort"},{"rate":null,"effect":"Transient numbness or paresthesia"},{"rate":null,"effect":"Systemic toxicity (rare, with overdose)"},{"rate":null,"effect":"Allergic reactions (rare)"}]},"_chembl":null,"_dailymed":null,"mechanism":{"_ai_source":"claude-haiku-4.5","explanation":"Ropivacaine is an amide-type local anesthetic that reversibly inhibits sodium influx through voltage-gated sodium channels in nerve cell membranes. This prevents depolarization and blocks nerve conduction in the injected area. When administered as an extraarticular injection, it provides localized anesthesia and analgesia at the injection site and surrounding tissues.","oneSentence":"Ropivacaine is a local anesthetic that blocks sodium channels in nerve fibers, preventing the initiation and propagation of action potentials to produce local anesthesia.","_ai_confidence":"medium"},"_scrapedAt":"2026-03-27T23:46:09.726Z","_scrapedBy":"cloudflare-swarm","_wikipedia":null,"indications":{"approved":[{"name":"Local anesthesia for extraarticular procedures and pain management"}]},"trialDetails":[{"nctId":"NCT00632580","phase":"PHASE4","title":"Intra- Versus Extraarticular Injection of Ropivacaine in Total Knee Arthroplasty","status":"UNKNOWN","sponsor":"Hvidovre University Hospital","startDate":"2008-01","conditions":"Pain, Postoperative","enrollment":60}],"_emaApprovals":[],"_faersSignals":[],"_approvalHistory":[],"publicationCount":0,"rwe":[],"genericFilers":[],"relatedDrugs":[],"labelChanges":[],"biosimilarFilings":[],"pricing":[],"formularyStatus":[],"manufacturing":[],"companionDiagnostics":[],"competitors":[],"timeline":[],"patents":[],"ownershipHistory":[],"trials":[],"biosimilars":[],"latestUpdates":[],"references":[],"tags":[],"ecosystem":[],"genericManufacturerList":[],"offLabel":[],"developmentCodes":[],"aliases":[],"phase":"marketed","status":"active","brandName":"extraarticular injection with ropivacaine","genericName":"extraarticular injection with ropivacaine","companyName":"Hvidovre University Hospital","companyId":"hvidovre-university-hospital","modality":"Small molecule","firstApprovalDate":"","aiSummary":"Ropivacaine is a local anesthetic that blocks sodium channels in nerve fibers, preventing the initiation and propagation of action potentials to produce local anesthesia. Used for Local anesthesia for extraarticular procedures and pain management.","enrichmentLevel":3,"visitCount":1,"trialStats":{"total":0,"withResults":0},"verificationStatus":"verified","dataCompleteness":{"mechanism":true,"indications":true,"safety":true,"trials":true,"score":4}}