{"id":"experimental-drug-ondansetron","safety":{"commonSideEffects":[{"rate":"9-27%","effect":"Headache"},{"rate":"5-25%","effect":"Constipation"},{"rate":"3-15%","effect":"Diarrhea"},{"rate":"5-13%","effect":"Fatigue"},{"rate":"4-13%","effect":"Dizziness"},{"rate":null,"effect":"QT prolongation"}]},"_chembl":null,"_dailymed":null,"mechanism":{"_ai_source":"claude-haiku-4.5","explanation":"Ondansetron is a selective antagonist of serotonin 5-HT3 receptors, which are located in the chemoreceptor trigger zone and on vagal afferent fibers in the gastrointestinal tract. By blocking these receptors, it prevents the transmission of emetic signals to the vomiting center in the brainstem. This mechanism makes it particularly effective for chemotherapy-induced nausea and vomiting (CINV) and postoperative nausea and vomiting (PONV).","oneSentence":"Ondansetron blocks serotonin 5-HT3 receptors on chemoreceptor trigger zone and vagal afferent nerves to prevent nausea and vomiting.","_ai_confidence":"high"},"_scrapedAt":"2026-03-28T01:12:01.145Z","_scrapedBy":"cloudflare-swarm","_wikipedia":null,"indications":{"approved":[{"name":"Chemotherapy-induced nausea and vomiting (CINV)"},{"name":"Postoperative nausea and vomiting (PONV)"},{"name":"Radiation-induced nausea and vomiting"}]},"trialDetails":[{"nctId":"NCT06632184","phase":"PHASE4","title":"Peritoneal Lavage Using Saline or Saline With Ondansetron for Pain Control After Laparoscopic Cholecystectomy","status":"ACTIVE_NOT_RECRUITING","sponsor":"Instituto Mexicano del Seguro Social","startDate":"2025-12-01","conditions":"Postoperative Pain Management, Laparoscopic Cholecystectomy, 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Neoplasms","enrollment":866},{"nctId":"NCT01691690","phase":"PHASE2","title":"Analgesic Effect of IV Acetaminophen in Tonsillectomies","status":"COMPLETED","sponsor":"Nationwide Children's Hospital","startDate":"2012-10","conditions":"Adenotonsillitis, Tonsillitis","enrollment":250},{"nctId":"NCT00745004","phase":"PHASE4","title":"Ondansetron for the Treatment of IBS With Diarrhoea (IBS-D)","status":"COMPLETED","sponsor":"University of Nottingham","startDate":"2009-01","conditions":"Irritable Bowel Syndrome With 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Used for Chemotherapy-induced nausea and vomiting (CINV), Postoperative nausea and vomiting (PONV), Radiation-induced nausea and vomiting.","enrichmentLevel":3,"visitCount":0,"trialStats":{"total":1,"withResults":0},"verificationStatus":"verified","dataCompleteness":{"mechanism":true,"indications":true,"safety":true,"trials":true,"score":4}}