{"id":"experimental-drug-aprepitant","safety":{"commonSideEffects":[{"rate":null,"effect":"Fatigue"},{"rate":null,"effect":"Headache"},{"rate":null,"effect":"Constipation"},{"rate":null,"effect":"Diarrhea"},{"rate":null,"effect":"Hiccups"}]},"_chembl":null,"_dailymed":null,"mechanism":{"_ai_source":"claude-haiku-4.5","explanation":"Aprepitant is a selective antagonist of the neurokinin-1 (NK1) receptor, which plays a key role in the chemoreceptor trigger zone and vomiting center. By crossing the blood-brain barrier and occupying NK1 receptors, it prevents the transmission of emetic signals triggered by chemotherapy and other emetogenic stimuli. This mechanism is particularly effective for delayed chemotherapy-induced nausea and vomiting (CINV).","oneSentence":"Aprepitant blocks neurokinin-1 (NK1) receptors in the brain to prevent nausea and vomiting.","_ai_confidence":"high"},"_scrapedAt":"2026-03-28T01:12:04.511Z","_scrapedBy":"cloudflare-swarm","_wikipedia":null,"indications":{"approved":[{"name":"Chemotherapy-induced nausea and vomiting (CINV) prevention in patients receiving highly emetogenic chemotherapy"},{"name":"Post-operative nausea and vomiting (PONV) prevention"}]},"trialDetails":[{"nctId":"NCT06952920","phase":"PHASE3","title":"Electroacupuncture for Chemotherapy-Induced GI Symptom Clusters in Breast Cancer","status":"RECRUITING","sponsor":"Jiuda Zhao","startDate":"2025-08-21","conditions":"Standard Quadruple Antiemetic Therapy, Electroacupuncture, Chemotherapy-induced Gastrointestinal Symptom Cluster","enrollment":388},{"nctId":"NCT06740812","phase":"PHASE4","title":"Broadening Antiemetics Research by Comparing the Effectiveness of Fosaprepitant and Metoclopramide","status":"NOT_YET_RECRUITING","sponsor":"Montefiore Medical Center","startDate":"2026-05","conditions":"Nausea and Vomiting, Nausea, Vomiting","enrollment":212},{"nctId":"NCT05773950","phase":"NA","title":"Triple Therapy of Dexamethasone, Palonosetron, and Fosaprepitant As PONV Prevention","status":"ENROLLING_BY_INVITATION","sponsor":"Samsung Medical Center","startDate":"2023-08-18","conditions":"Postoperative Nausea and Vomiting, Gynecologic Surgical Procedures, Laparoscopy","enrollment":144},{"nctId":"NCT03079219","phase":"PHASE3","title":"Olanzapine for the Prevention of Chemotherapy-Induced Nausea and Vomiting in Chinese Breast Cancer Patients","status":"COMPLETED","sponsor":"CCTU","startDate":"2017-03-23","conditions":"Breast Cancer","enrollment":120},{"nctId":"NCT02210195","phase":"PHASE2","title":"Pharmacological Treatment of Comorbid Alcohol and Marijuana Withdrawal and Dependence","status":"COMPLETED","sponsor":"The Scripps Research Institute","startDate":"2014-09-04","conditions":"Cannabis Dependence, Alcohol Dependence, Cannabis Use Disorder","enrollment":20},{"nctId":"NCT00092183","phase":"PHASE4","title":"An Investigational Drug for the Prevention of Chemotherapy-Induced Nausea and Vomiting (MK-0869-071)","status":"COMPLETED","sponsor":"Merck Sharp & Dohme LLC","startDate":"2002-10-10","conditions":"Nausea, Vomiting, Breast Neoplasms","enrollment":866}],"_emaApprovals":[],"_faersSignals":[],"_approvalHistory":[],"publicationCount":1,"rwe":[],"genericFilers":[],"relatedDrugs":[],"labelChanges":[],"biosimilarFilings":[],"pricing":[],"formularyStatus":[],"manufacturing":[],"companionDiagnostics":[],"competitors":[],"timeline":[],"patents":[],"ownershipHistory":[],"trials":[],"biosimilars":[],"latestUpdates":[],"references":[],"tags":[],"ecosystem":[],"genericManufacturerList":[],"offLabel":[],"developmentCodes":[],"aliases":[],"phase":"phase_3","status":"active","brandName":"Experimental drug: Aprepitant","genericName":"Experimental drug: Aprepitant","companyName":"CCTU","companyId":"cctu","modality":"Small molecule","firstApprovalDate":"","aiSummary":"Aprepitant blocks neurokinin-1 (NK1) receptors in the brain to prevent nausea and vomiting. Used for Chemotherapy-induced nausea and vomiting (CINV) prevention in patients receiving highly emetogenic chemotherapy, Post-operative nausea and vomiting (PONV) prevention.","enrichmentLevel":3,"visitCount":0,"trialStats":{"total":1,"withResults":0},"verificationStatus":"verified","dataCompleteness":{"mechanism":true,"indications":true,"safety":true,"trials":true,"score":4}}