{"id":"experimental-denture-adhesive","safety":{"commonSideEffects":[{"rate":null,"effect":"Oral irritation or mucosal sensitivity"},{"rate":null,"effect":"Difficulty with denture removal"},{"rate":null,"effect":"Taste alteration"}]},"_chembl":null,"_dailymed":null,"mechanism":{"_ai_source":"claude-haiku-4.5","explanation":"Denture adhesives work by creating a physical and chemical bond between the denture base and the underlying oral mucosa, improving retention, stability, and comfort during mastication and speech. This experimental formulation from GSK likely incorporates novel polymeric or adhesive components designed to improve biocompatibility, duration of hold, or ease of removal compared to existing products.","oneSentence":"A denture adhesive formulation that enhances the mechanical retention and seal of dentures to oral tissues.","_ai_confidence":"low"},"_scrapedAt":"2026-03-28T00:46:36.005Z","_scrapedBy":"cloudflare-swarm","_wikipedia":null,"indications":{"approved":[{"name":"Denture retention and stability in edentulous patients"}]},"trialDetails":[{"nctId":"NCT07496164","phase":"NA","title":"A Clinical Study Assessing the Maximum Maxillary Bite Force When Using Three Denture Adhesives Compared to Using No-Adhesive","status":"NOT_YET_RECRUITING","sponsor":"HALEON","startDate":"2026-03","conditions":"Denture Retention","enrollment":60},{"nctId":"NCT06713577","phase":"","title":"Clinical Study of a 3D Shaded Zirconia for Chairside CAD/CAM Restorations","status":"ACTIVE_NOT_RECRUITING","sponsor":"Dentsply Sirona Implants and Consumables","startDate":"2024-12-03","conditions":"Dental Prosthesis Failure, Dental Prosthesis Complication","enrollment":82},{"nctId":"NCT07289971","phase":"PHASE3","title":"Comparative Evaluation of Clinical and Radiographic Treatment Outcomes of Garlic Gel and Calcium Hydroxide as an Intracanal Medicament in Nonsurgical Root Canal Treatment of Permanent Teeth.","status":"NOT_YET_RECRUITING","sponsor":"University of Health Sciences Lahore","startDate":"2026-01-20","conditions":"Apical Periodontitis, Periapical Radiolucency","enrollment":96},{"nctId":"NCT07302581","phase":"NA","title":"Efficacy and Safety Evaluation Study of Implants With Periodontal Ligament","status":"RECRUITING","sponsor":"OrganTech, Inc.","startDate":"2025-06-20","conditions":"Tooth Extraction, Tooth Fractures, Dental Caries","enrollment":6},{"nctId":"NCT07040722","phase":"NA","title":"Effects of the Use of an Immersive Virtual Reality Device on Handwriting in Children Aged 6 to 13 With Handwriting Difficulties ( RVALIGO )","status":"RECRUITING","sponsor":"Fondation Ildys","startDate":"2025-10-01","conditions":"Children With a Need of Rehabilitation for Handwriting","enrollment":12},{"nctId":"NCT07290049","phase":"NA","title":"Postoperative Pain After Pulpotomy in Children Using Calcium Silicate Cements With and Without Laser Therapy","status":"RECRUITING","sponsor":"University of Fujairah","startDate":"2025-04-24","conditions":"Symptomatic Irreversible Pulpitis, Symptomatic Irreversible Pulpitis (SIP)","enrollment":46},{"nctId":"NCT07244081","phase":"NA","title":"Kinesiotherapy on Upper Limb Function and Activities of Daily Living in Children With Hemiplegic Cerebral Palsy","status":"RECRUITING","sponsor":"Riphah International University","startDate":"2025-10-22","conditions":"Hemiplegic Cerebral Palsy","enrollment":28},{"nctId":"NCT07192289","phase":"NA","title":"Using Platelet-rich Fibrin in Regenerative Endodontic Treatment in Mature Permanent Teeth","status":"NOT_YET_RECRUITING","sponsor":"University of Medicine and Pharmacy at Ho Chi Minh City","startDate":"2025-09-15","conditions":"Chronic Apical Periodontitis, Necrosis of Pulp, Acute Apical Periodontitis of Pulpal Origin","enrollment":57},{"nctId":"NCT07103330","phase":"NA","title":"Evaluation of Cranial Flap Fixation With Montage Flowable Settable Bone Paste","status":"NOT_YET_RECRUITING","sponsor":"Abyrx, Inc.","startDate":"2026-03","conditions":"Cranial Bone, Post-operative Complications, Cranial Fixation","enrollment":100},{"nctId":"NCT06187337","phase":"NA","title":"Interceptive Maxillary Expansion to Relief Anterior Crowding in the Mixed Dentition","status":"RECRUITING","sponsor":"Region Örebro County","startDate":"2021-12-20","conditions":"Crowding of Anterior Maxillary Teeth, Orthodontics, Interceptive, Orthodontics, Corrective, Palatal Expansion Technique","enrollment":60},{"nctId":"NCT07027709","phase":"NA","title":"Clinical Performance of Hybrid Ceramic Laminate Veneers","status":"RECRUITING","sponsor":"Cairo University","startDate":"2025-06-01","conditions":"Bonding of Veneers After Different Treatment","enrollment":28},{"nctId":"NCT05607030","phase":"PHASE2","title":"A Second Trial of the Abbreviated Protocol Two-Stage Exchange","status":"COMPLETED","sponsor":"Osteal Therapeutics, Inc.","startDate":"2023-01-23","conditions":"Prosthetic-joint Infection","enrollment":76},{"nctId":"NCT06752889","phase":"NA","title":"Clinical and Radiographic Evaluation of Zinc Oxide Modified 3Mixtatin Versus Zical in Root Canal Treatment of Necrotic Primary Molars.","status":"RECRUITING","sponsor":"Ain Shams University","startDate":"2024-01-01","conditions":"Necrotic Pulp, Primary Teeth","enrollment":34},{"nctId":"NCT04692714","phase":"NA","title":"Evaluation of Two Surgical Strategies for Robotic Implantation of Total Knee Prostheses (Stryker), Cemented Versus Uncemented","status":"RECRUITING","sponsor":"Hospices Civils de Lyon","startDate":"2022-05-16","conditions":"Total Knee Arthroplasty","enrollment":200},{"nctId":"NCT04662632","phase":"PHASE2","title":"Abbreviated Protocol for Two-Stage Exchange","status":"COMPLETED","sponsor":"Osteal Therapeutics, Inc.","startDate":"2021-11-01","conditions":"Prosthetic Joint Infection","enrollment":76},{"nctId":"NCT05173974","phase":"PHASE3","title":"A Clinical Study to Evaluate the Maximum Maxillary Bite Force (BF) When Using Two Novel Denture Adhesives Compared to Using No-Adhesive","status":"COMPLETED","sponsor":"HALEON","startDate":"2022-02-08","conditions":"Denture Retention","enrollment":45},{"nctId":"NCT06161103","phase":"NA","title":"Comparison of 3D Printed Composite Resin Crowns With Stainless Steel Crowns","status":"NOT_YET_RECRUITING","sponsor":"Marmara University","startDate":"2023-11-30","conditions":"Carious Teeth","enrollment":50},{"nctId":"NCT05318690","phase":"NA","title":"PlayGait: A Dynamic Exoskeleton","status":"TERMINATED","sponsor":"Orthocare Innovations, LLC","startDate":"2022-03-11","conditions":"Cerebral Palsy","enrollment":1},{"nctId":"NCT06002698","phase":"NA","title":"Full Pulpotomy Versus Root Canal Treatment for Teeth With Symptomatic Irreversible Pulpitis","status":"UNKNOWN","sponsor":"University of Malaya","startDate":"2023-08-08","conditions":"Pulpitis - Irreversible","enrollment":60},{"nctId":"NCT04036539","phase":"NA","title":"Photobiomodulation on Molar Verticalization With Mini-implant","status":"COMPLETED","sponsor":"University of Nove de Julho","startDate":"2020-11-15","conditions":"Orthodontic Appliances, Low-Level Light Therapy","enrollment":34},{"nctId":"NCT05908890","phase":"NA","title":"A Study to Determine the Efficacy of a Denture Adhesive to Seal Out Food Particles From Under the Mandibular Partial Denture","status":"COMPLETED","sponsor":"Procter and Gamble","startDate":"2019-07-08","conditions":"Partial Denture","enrollment":29},{"nctId":"NCT04385693","phase":"NA","title":"Intentional Pulpotomy to Preserve Hopeless Molars","status":"COMPLETED","sponsor":"University of Florida","startDate":"2020-06-12","conditions":"Pulpitis, Dental Pulp Diseases, Tooth Diseases","enrollment":17},{"nctId":"NCT05012293","phase":"NA","title":"Cognitive Fatigue, Self-Regulation, and Academic Performance: A Physiological Study","status":"UNKNOWN","sponsor":"Nanyang Technological University","startDate":"2021-08-26","conditions":"Cognitive Fatigue, Mental Fatigue, Behavioral Performance","enrollment":162},{"nctId":"NCT05009784","phase":"NA","title":"Effects of Natural Sounds on Attention Restoration in Noisy Environment","status":"UNKNOWN","sponsor":"Nanyang Technological University","startDate":"2021-08-25","conditions":"Cognitive Fatigue, Mental Fatigue, Heart Rate Variability","enrollment":162},{"nctId":"NCT05677945","phase":"NA","title":"3Mixtatin Versus Modified 3Mix-MP in Lesion Sterilization and Tissue Repair for Treatment of Necrotic Primary Molars","status":"UNKNOWN","sponsor":"Cairo University","startDate":"2023-03","conditions":"Necrotic Primary Molars","enrollment":24},{"nctId":"NCT02006251","phase":"","title":"Real-Time Instrument for Acetabular Shell Positioning","status":"TERMINATED","sponsor":"The Cleveland Clinic","startDate":"2013-11","conditions":"Total Hip Arthroplasty","enrollment":24},{"nctId":"NCT02071953","phase":"NA","title":"Comparative Study of Experimental Dental Adhesive With and Without Phosphoric Acid Pretreatment","status":"COMPLETED","sponsor":"Dentsply International","startDate":"2012-04","conditions":"Dental Caries","enrollment":37},{"nctId":"NCT03889535","phase":"NA","title":"Anterior Zirconia vs. Resin Strip Crowns","status":"COMPLETED","sponsor":"The Hospital for Sick Children","startDate":"2019-04-11","conditions":"Caries, Dental","enrollment":59},{"nctId":"NCT05117268","phase":"NA","title":"ASSESSMENT OF SDF vs. GIC AND HALL TECHNIQUE","status":"UNKNOWN","sponsor":"Foundation University Islamabad","startDate":"2021-10-01","conditions":"Dental Caries","enrollment":132},{"nctId":"NCT03885271","phase":"NA","title":"Outcomes of the Hall Technique and Conventional Pulp Therapy for the Management of Caries in Primary Molars","status":"COMPLETED","sponsor":"Cairo University","startDate":"2020-05-01","conditions":"Deep Caries, Pulpitis - Reversible","enrollment":56},{"nctId":"NCT03807700","phase":"PHASE3","title":"To Evaluate Oral Health and Quality of Life Associated With Use of a Denture Adhesive","status":"COMPLETED","sponsor":"GlaxoSmithKline","startDate":"2019-02-04","conditions":"Denture Retention","enrollment":119},{"nctId":"NCT04942262","phase":"PHASE3","title":"Oral Health-related Quality of Life and Masticatory Function After Using Denture Adhesive and Denture Liner","status":"COMPLETED","sponsor":"Chulalongkorn University","startDate":"2019-01-31","conditions":"Complete Denture, Complete Edentulism","enrollment":80},{"nctId":"NCT04473521","phase":"PHASE3","title":"A Clinical Study to Assess Force Required to Dislodge Upper Denture With and Without Use of a Novel Denture Adhesive","status":"WITHDRAWN","sponsor":"GlaxoSmithKline","startDate":"2020-10-04","conditions":"Denture Retention","enrollment":""},{"nctId":"NCT04491097","phase":"NA","title":"Clinical Outcomes of CAD/CAM Single-Retainer Monolithic Zirconia Ceramic Resin-Bonded Fixed Dentures Bonded With Two Different Resin Cements","status":"UNKNOWN","sponsor":"Istanbul Medipol University Hospital","startDate":"2017-06-01","conditions":"Denture, Partial, Fixed, Resin-Bonded, Tooth Loss / Rehabilitation, Resin Cements","enrollment":20},{"nctId":"NCT02903979","phase":"NA","title":"Impact of Different Restorative Treatments for Deep Caries Lesion in Primary Teeth","status":"COMPLETED","sponsor":"Universidade Ibirapuera","startDate":"2016-11","conditions":"Deep Caries Lesion of Primary Teeth","enrollment":108},{"nctId":"NCT03855527","phase":"PHASE2","title":"Effectiveness of Silver Diamine Fluoride as Cavity Disinfectant After Atraumatic Restorative Treatment in Primary Teeth","status":"COMPLETED","sponsor":"Nourhan M.Aly","startDate":"2018-01-12","conditions":"Dental Caries","enrollment":60},{"nctId":"NCT03936855","phase":"NA","title":"Clinical Evaluation of Posterior Direct Restoration in Adolescents","status":"COMPLETED","sponsor":"Renata Afonso da Silva Pereira","startDate":"2016-01","conditions":"Composite Resins","enrollment":54},{"nctId":"NCT03729856","phase":"NA","title":"A Novel Intervention to Promote Engagement in Physical Activity for Individuals With Whiplash Associated Disorder","status":"COMPLETED","sponsor":"The University of Queensland","startDate":"2018-05-07","conditions":"Whiplash Injuries, Sedentary Lifestyle","enrollment":6},{"nctId":"NCT03916900","phase":"NA","title":"Postoperative Pain and Success Rate in Pulpotomy Versus Root Canal Treatment","status":"UNKNOWN","sponsor":"Cairo University","startDate":"2019-06-01","conditions":"Pulpitis - Irreversible","enrollment":52},{"nctId":"NCT03403088","phase":"NA","title":"Non-carious Cervical Lesions and Treatments","status":"COMPLETED","sponsor":"University of Sao Paulo","startDate":"2017-08-01","conditions":"Tooth Sensitivity","enrollment":60},{"nctId":"NCT02928380","phase":"NA","title":"Evaluation of a Experimental Denture Adhesive to Prevent Food Ingress","status":"COMPLETED","sponsor":"GlaxoSmithKline","startDate":"2016-07-25","conditions":"Denture Retention","enrollment":83},{"nctId":"NCT02494193","phase":"NA","title":"Indirect Pulp Capping With Resin Modified Glass Ionomer","status":"COMPLETED","sponsor":"Universidade Federal de Sergipe","startDate":"2015-06","conditions":"Caries, Dental, Pulpitis","enrollment":112},{"nctId":"NCT02363608","phase":"","title":"Animal Assisted Activity Program on Patients and Staff on an Inpatient Surgical Oncology Unit","status":"COMPLETED","sponsor":"Memorial Sloan Kettering Cancer Center","startDate":"2015-01","conditions":"Postoperative Care","enrollment":146},{"nctId":"NCT01817413","phase":"PHASE4","title":"Comparison of Two Dental Techniques Used to Treat Teeth Which Have Become Infected or Painful Following Trauma","status":"COMPLETED","sponsor":"University of Liverpool","startDate":"2011-02","conditions":"Apexification, Apexogenesis, Pulp Necrosis","enrollment":30},{"nctId":"NCT02386943","phase":"PHASE4","title":"Study on Exploring the Effect of DPP-4 Inhibitors on β-cell Function by Using the Two-step Hyperglycemic Clamp","status":"UNKNOWN","sponsor":"Shanghai Jiao Tong University School of Medicine","startDate":"2013-12","conditions":"Type 2 Diabetes","enrollment":12},{"nctId":"NCT01660386","phase":"PHASE4","title":"Study of Comparing the Different Effect of DPP-4 Inhibitors and Sulfonylurea by Using \"Biphase-Hyperglycemic Clamp\"","status":"UNKNOWN","sponsor":"Shanghai Jiao Tong University School of Medicine","startDate":"2012-07","conditions":"Type 2 Diabetes","enrollment":12},{"nctId":"NCT00594321","phase":"NA","title":"Evaluation of Fracture Fixation With Energy and Cement in Tumors of the Spine","status":"WITHDRAWN","sponsor":"University of California, Davis","startDate":"2007-07","conditions":"Spinal Fractures","enrollment":""}],"_emaApprovals":[],"_faersSignals":[],"_approvalHistory":[],"publicationCount":20,"rwe":[],"genericFilers":[],"relatedDrugs":[],"labelChanges":[],"biosimilarFilings":[],"pricing":[],"formularyStatus":[],"manufacturing":[],"companionDiagnostics":[],"competitors":[],"timeline":[],"patents":[],"ownershipHistory":[],"trials":[],"biosimilars":[],"latestUpdates":[],"references":[],"tags":[],"ecosystem":[],"genericManufacturerList":[],"offLabel":[],"developmentCodes":[],"aliases":[],"phase":"phase_3","status":"active","brandName":"Experimental Denture Adhesive","genericName":"Experimental Denture Adhesive","companyName":"GlaxoSmithKline","companyId":"glaxosmithkline","modality":"Small molecule","firstApprovalDate":"","aiSummary":"A denture adhesive formulation that enhances the mechanical retention and seal of dentures to oral tissues. Used for Denture retention and stability in edentulous patients.","enrichmentLevel":3,"visitCount":0,"trialStats":{"total":2,"withResults":2},"verificationStatus":"verified","dataCompleteness":{"mechanism":true,"indications":true,"safety":true,"trials":true,"score":4}}