{"id":"experimental-alpha-blocker-group","safety":{"commonSideEffects":[{"rate":null,"effect":"Dizziness"},{"rate":null,"effect":"Headache"},{"rate":null,"effect":"Fatigue"},{"rate":null,"effect":"Orthostatic hypotension"},{"rate":null,"effect":"Syncope"}]},"_chembl":null,"_dailymed":null,"mechanism":{"_ai_source":"claude-haiku-4.5","explanation":"Alpha-blockers selectively block alpha-1 adrenergic receptors, which mediate vasoconstriction and smooth muscle contraction in blood vessels and the prostate. By antagonizing these receptors, they reduce peripheral vascular resistance and relax prostatic smooth muscle, lowering blood pressure and improving urinary flow in benign prostatic hyperplasia.","oneSentence":"Alpha-blockers inhibit alpha-adrenergic receptors on vascular smooth muscle and the prostate, causing vasodilation and reduced urinary obstruction.","_ai_confidence":"medium"},"_scrapedAt":"2026-03-28T00:39:30.001Z","_scrapedBy":"cloudflare-swarm","_wikipedia":null,"indications":{"approved":[{"name":"Hypertension"},{"name":"Benign prostatic hyperplasia with lower urinary tract symptoms"}]},"trialDetails":[{"nctId":"NCT07124299","phase":"PHASE4","title":"Alpha-Blockers Prior to Ureteral Access Sheath Placement in Flexible Ureteroscopy: A Randomized Prospective Study","status":"RECRUITING","sponsor":"Pedro de Figueiredo Buchalla","startDate":"2024-01-01","conditions":"Nephrolithiasis, Alpha Blocker, Ureteral Access Sheath","enrollment":140}],"_emaApprovals":[],"_faersSignals":[],"_approvalHistory":[],"publicationCount":0,"rwe":[],"genericFilers":[],"relatedDrugs":[],"labelChanges":[],"biosimilarFilings":[],"pricing":[],"formularyStatus":[],"manufacturing":[],"companionDiagnostics":[],"competitors":[],"timeline":[],"patents":[],"ownershipHistory":[],"trials":[],"biosimilars":[],"latestUpdates":[],"references":[],"tags":[],"ecosystem":[],"genericManufacturerList":[],"offLabel":[],"developmentCodes":[],"aliases":[],"phase":"marketed","status":"active","brandName":"Experimental: Alpha-blocker group","genericName":"Experimental: Alpha-blocker group","companyName":"Pedro de Figueiredo Buchalla","companyId":"pedro-de-figueiredo-buchalla","modality":"Small molecule","firstApprovalDate":"","aiSummary":"Alpha-blockers inhibit alpha-adrenergic receptors on vascular smooth muscle and the prostate, causing vasodilation and reduced urinary obstruction. Used for Hypertension, Benign prostatic hyperplasia with lower urinary tract symptoms.","enrichmentLevel":3,"visitCount":0,"trialStats":{"total":0,"withResults":0},"verificationStatus":"verified","dataCompleteness":{"mechanism":true,"indications":true,"safety":true,"trials":true,"score":4}}