{"id":"exparel-with-bubivacaine","safety":{"commonSideEffects":[{"rate":null,"effect":"Postoperative nausea"},{"rate":null,"effect":"Postoperative vomiting"},{"rate":null,"effect":"Dizziness"},{"rate":null,"effect":"Headache"},{"rate":null,"effect":"Hypotension"}]},"_chembl":null,"_dailymed":null,"mechanism":{"_ai_source":"claude-haiku-4.5","explanation":"Bupivacaine is a long-acting local anesthetic that blocks sodium channels in nerve cell membranes, preventing depolarization and transmission of nerve impulses. The liposomal encapsulation (DepoFoam technology) allows sustained release of the drug over an extended period, providing analgesia for up to 72 hours after a single infiltration, compared to 4-8 hours with standard bupivacaine.","oneSentence":"Exparel is a liposomal formulation of bupivacaine that provides prolonged local anesthetic effect by slowly releasing bupivacaine from lipid vesicles at the injection site.","_ai_confidence":"high"},"_scrapedAt":"2026-03-27T23:46:07.737Z","_scrapedBy":"cloudflare-swarm","_wikipedia":null,"indications":{"approved":[{"name":"Infiltration anesthesia and nerve block in adults for surgical anesthesia and postoperative analgesia"}]},"trialDetails":[{"nctId":"NCT05823363","phase":"PHASE4","title":"Vaginal Cuff Infiltration With Liposomal Bupivacaine for Pain Relief: A Double Blind, Randomized Controlled Trial","status":"COMPLETED","sponsor":"Maimonides Medical Center","startDate":"2024-09-09","conditions":"Postoperative Pain","enrollment":15}],"_emaApprovals":[],"_faersSignals":[],"_approvalHistory":[],"publicationCount":3,"rwe":[],"genericFilers":[],"relatedDrugs":[],"labelChanges":[],"biosimilarFilings":[],"pricing":[],"formularyStatus":[],"manufacturing":[],"companionDiagnostics":[],"competitors":[],"timeline":[],"patents":[],"ownershipHistory":[],"trials":[],"biosimilars":[],"latestUpdates":[],"references":[],"tags":[],"ecosystem":[],"genericManufacturerList":[],"offLabel":[],"developmentCodes":[],"aliases":[],"phase":"marketed","status":"active","brandName":"Exparel with Bubivacaine","genericName":"Exparel with Bubivacaine","companyName":"Maimonides Medical Center","companyId":"maimonides-medical-center","modality":"Small molecule","firstApprovalDate":"","aiSummary":"Exparel is a liposomal formulation of bupivacaine that provides prolonged local anesthetic effect by slowly releasing bupivacaine from lipid vesicles at the injection site. Used for Infiltration anesthesia and nerve block in adults for surgical anesthesia and postoperative analgesia.","enrichmentLevel":3,"visitCount":0,"trialStats":{"total":0,"withResults":0},"verificationStatus":"verified","dataCompleteness":{"mechanism":true,"indications":true,"safety":true,"trials":true,"score":4}}