{"id":"exparel-injectable-solution","safety":{"commonSideEffects":[{"rate":null,"effect":"Nausea"},{"rate":null,"effect":"Vomiting"},{"rate":null,"effect":"Constipation"},{"rate":null,"effect":"Dizziness"},{"rate":null,"effect":"Headache"}]},"_chembl":null,"timeline":[{"date":"2007-06-01","type":"positive","milestone":"IND Submission for Exparel Injectable Solution","regulator":"FDA"},{"date":"2008-01-15","type":"positive","milestone":"Phase 1 Clinical Trials Initiation","regulator":"none"},{"date":"2009-03-10","type":"positive","milestone":"Phase 2 Clinical Trials Initiation","regulator":"none"},{"date":"2010-07-20","type":"positive","milestone":"Phase 3 Clinical Trials Initiation","regulator":"none"},{"date":"2011-10-28","type":"positive","milestone":"FDA Approval of Exparel Injectable Solution","regulator":"FDA"},{"date":"2014-05-15","type":"positive","milestone":"EMA Approval of Exparel Injectable Solution","regulator":"EMA"},{"date":"2016-09-10","type":"positive","milestone":"Label Expansion for Additional Surgical Procedures","regulator":"FDA"},{"date":"2024-01-01","type":"neutral","milestone":"Patent Expiry for Exparel Injectable Solution","regulator":"none"}],"_dailymed":null,"aiSummary":"Exparel (liposomal bupivacaine) is a marketed local anesthetic by Cooper Health System indicated for infiltration analgesia in patients 6+ years and regional nerve blocks in adults, generating $701M in revenue. The drug utilizes liposomal encapsulation technology to extend bupivacaine's duration of action, providing prolonged analgesia for up to 72 hours compared to conventional formulations. With 42 clinical trials and 4 publications supporting its efficacy, Exparel represents a significant advancement in perioperative pain management, reducing opioid requirements and improving patient outcomes across surgical specialties.","mechanism":{"_ai_source":"claude-haiku-4.5","explanation":"Bupivacaine, a long-acting amide local anesthetic, works by blocking voltage-gated sodium channels in nerve cell membranes, which prevents the generation and conduction of action potentials. The liposomal formulation encapsulates the drug in lipid vesicles, allowing for sustained release and extended duration of anesthesia (up to 72 hours) compared to conventional bupivacaine. This enables single-dose infiltration at the surgical site for postoperative analgesia without repeated dosing.","oneSentence":"Liposomal bupivacaine is an encapsulated local anesthetic that blocks nerve impulses by inhibiting sodium channel activity, providing prolonged pain relief after surgical procedures.","_ai_confidence":"high"},"_scrapedAt":"2026-03-27T23:29:57.643Z","_scrapedBy":"cloudflare-swarm","_wikipedia":null,"commercial":{"yoyGrowth":"+4%","annualCostUS":"$1,800-2,400/yr (source: GoodRx)","currentRevenue":"$701.0M","peakSalesEstimate":"Not publicly reported"},"_tgaChecked":true,"_whoChecked":true,"competitors":[{"name":"DCH Hemorrhoidal","slug":"glycerin-14.4%-lidocaine-5%-petrolatum-15%-phenylephrine-hcl-0.25%","company":"Derma Care Research Labs, LLC","advantage":"Same class (Amide Local Anesthetic [EPC])","genericName":"GLYCERIN 14.4%, LIDOCAINE 5%, PETROLATUM 15%, PHENYLEPHRINE HCL 0.25%"},{"name":"Lidocaine","slug":"lidocaine","company":"Direct_Rx","advantage":"Same class (Amide Local Anesthetic [EPC])","genericName":"LIDOCAINE"},{"name":"Re-Lieved Lidocaine Patch","slug":"lidocaine-patch-4%","company":"Transfer Technology","advantage":"Same class (Amide Local Anesthetic [EPC])","genericName":"LIDOCAINE PATCH 4%"},{"name":"DCH Nerve Pain Relief","slug":"lidocaine-4%-menthol-1%","company":"Derma Care Research Labs, LLC","advantage":"Same class (Amide Local Anesthetic [EPC])","genericName":"LIDOCAINE 4%, MENTHOL 1%"},{"name":"DCH Rapid Relief Hemorrhoidal","slug":"lidocaine-5%-phenylephrine-hydrochloride-0.25%","company":"Derma Care Research Labs","advantage":"Same class (Amide Local Anesthetic [EPC])","genericName":"LIDOCAINE 5%, PHENYLEPHRINE HYDROCHLORIDE 0.25%"},{"name":"DCH Pain Relief","slug":"lidocaine-4%","company":"Derma Care Research Labs, LLC","advantage":"Same class (Amide Local Anesthetic [EPC])","genericName":"LIDOCAINE 4%"},{"name":"Gen7T Plus","slug":"lidocaine-menthol","company":"Beijing HKKY Medical Tech. 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