{"id":"exparel-and-bupivacaine-hcl","safety":{"commonSideEffects":[{"rate":null,"effect":"Postoperative nausea"},{"rate":null,"effect":"Postoperative vomiting"},{"rate":null,"effect":"Dizziness"},{"rate":null,"effect":"Headache"},{"rate":null,"effect":"Hypotension"},{"rate":null,"effect":"Tachycardia"}]},"_chembl":null,"_dailymed":null,"mechanism":{"_ai_source":"claude-haiku-4.5","explanation":"Bupivacaine is a local anesthetic that works by inhibiting sodium influx through sodium-selective ion channels in the nerve cell membrane, thereby blocking the initiation and conduction of nerve impulses. EXPAREL encapsulates bupivacaine in liposomes, which extend the duration of anesthesia from hours to up to 72 hours by providing sustained release of the active drug at the injection site. This allows for prolonged postoperative pain control without repeated dosing.","oneSentence":"EXPAREL is a liposomal formulation of bupivacaine that provides prolonged local anesthesia by slowly releasing bupivacaine from lipid vesicles to block sodium channels in nerve fibers.","_ai_confidence":"high"},"_scrapedAt":"2026-03-28T00:36:03.983Z","_scrapedBy":"cloudflare-swarm","_wikipedia":null,"indications":{"approved":[{"name":"Infiltration anesthesia and nerve block in adults for surgical anesthesia and postoperative analgesia"},{"name":"Interscalene brachial plexus nerve block for postoperative analgesia"}]},"trialDetails":[{"nctId":"NCT06565910","phase":"PHASE4","title":"Bupivacaine Liposome Plus Bupivacaine or Ropivacaine for Pericapsular Nerve Group Block in Hip Arthroplasty (PENG)","status":"RECRUITING","sponsor":"Huazhong University of Science and Technology","startDate":"2024-12-04","conditions":"Femoral Neck Fractures, Femur Head Necrosis, Hip 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Liposome Serrate Anterior Plane Block vs Traditional Thoracic Paravertebral Block","status":"WITHDRAWN","sponsor":"Shiyou Wei","startDate":"2023-10-01","conditions":"Lung Cancer","enrollment":""},{"nctId":"NCT03094663","phase":"PHASE4","title":"Adductor Canal Block With Periarticular Injection and IPACK (ACB/PAI/IPACK) Versus Periarticular Injection (PAI)","status":"COMPLETED","sponsor":"Hospital for Special Surgery, New York","startDate":"2017-02-28","conditions":"Knee Arthropathy","enrollment":86},{"nctId":"NCT04364867","phase":"PHASE4","title":"Exparel for Total Shoulder Arthroplasty","status":"COMPLETED","sponsor":"Norton Healthcare","startDate":"2020-08-12","conditions":"Total Shoulder Arthroplasty","enrollment":102},{"nctId":"NCT06252662","phase":"PHASE4","title":"Liposomal Bupivacaine Vs Bupivacaine with Dexmedetomidine in Erector Spinae Plane Blocks for Mastectomies","status":"RECRUITING","sponsor":"United States Naval Medical Center, Portsmouth","startDate":"2024-10-15","conditions":"Breast Cancer","enrollment":200},{"nctId":"NCT06452147","phase":"NA","title":"Anesthesia and Perioperative Neurocognitive Disorders in the Elderly Patients Undergoing Hip Fracture Surgery Platform Trial (ANDES Platform Trial)","status":"RECRUITING","sponsor":"Second Affiliated Hospital of Wenzhou Medical University","startDate":"2024-06-19","conditions":"Anesthesia, Hip Fractures, Dementia","enrollment":1860},{"nctId":"NCT06646172","phase":"NA","title":"Liposomal Bupivacaine and Bupivacaine for TTMPB in Median Sternotomy","status":"RECRUITING","sponsor":"Tongji Hospital","startDate":"2024-10-24","conditions":"Median Sternotomy","enrollment":38},{"nctId":"NCT05139030","phase":"PHASE3","title":"Phase 3 Adductor Canal Block With EXPAREL in Subjects Undergoing Primary Unilateral Total Knee Arthroplasty","status":"COMPLETED","sponsor":"Pacira Pharmaceuticals, Inc","startDate":"2022-01-18","conditions":"Knee Osteoarthritis, Pain 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