{"id":"ex-vivo-cultured-adult-allogeneic-mscs","safety":{"commonSideEffects":[{"rate":"null","effect":"Infusion-related reactions"},{"rate":"null","effect":"Infection"},{"rate":"null","effect":"Tumor progression"}]},"_chembl":null,"_dailymed":null,"mechanism":{"_ai_source":"groq-llama-8b","explanation":"The exact molecular targets of MSCs are not fully understood, but they are believed to interact with various cell surface receptors and signaling pathways to modulate immune responses, reduce inflammation, and promote angiogenesis. This leads to improved tissue repair and regeneration in various disease states.","oneSentence":"Ex- vivo cultured adult allogeneic MSCs are thought to exert their therapeutic effects through paracrine mechanisms, releasing various growth factors and cytokines that promote tissue repair and regeneration.","_ai_confidence":"medium"},"_scrapedAt":"2026-03-28T01:52:30.671Z","_scrapedBy":"cloudflare-swarm","_wikipedia":null,"indications":{"approved":[{"name":"Osteoarthritis"},{"name":"Bone nonunion"}]},"trialDetails":[{"nctId":"NCT05854615","phase":"PHASE4","title":"Efficacy and Safety of Stempeucel® in Patients With Critical Limb Ischemia (CLI) Due to Buerger's Disease","status":"RECRUITING","sponsor":"Cell Biopeutics Resources Sdn Bhd","startDate":"2024-01-01","conditions":"Critical Limb Ischemia, Buerger's Disease","enrollment":3},{"nctId":"NCT00136903","phase":"PHASE2","title":"Safety and Efficacy Study of Adult Human Mesenchymal Stem Cells to Treat Acute Graft Versus Host Disease (GVHD)","status":"COMPLETED","sponsor":"Mesoblast, Inc.","startDate":"2005-04-27","conditions":"Graft Vs Host Disease","enrollment":32},{"nctId":"NCT01453738","phase":"PHASE2","title":"Allogeneic Mesenchymal Stem Cells in Osteoarthritis","status":"COMPLETED","sponsor":"Stempeutics Research Pvt Ltd","startDate":"2011-11","conditions":"Osteoarthritis of Knee","enrollment":60},{"nctId":"NCT01448434","phase":"PHASE2","title":"Allogeneic Mesenchymal Stem Cells for Osteoarthritis","status":"COMPLETED","sponsor":"Stempeutics Research Pvt Ltd","startDate":"2011-09","conditions":"Osteoarthritis of Knee Joint","enrollment":72},{"nctId":"NCT01091701","phase":"PHASE1, PHASE2","title":"Ex Vivo Cultured Adult Allogenic MSCs in Ischemic Cerebral Stroke","status":"WITHDRAWN","sponsor":"Stempeutics Research Pvt Ltd","startDate":"2011-12","conditions":"Stroke","enrollment":""},{"nctId":"NCT00883727","phase":"PHASE1, PHASE2","title":"Ex Vivo Cultured Bone Marrow Derived Allogenic MSCs in AMI","status":"COMPLETED","sponsor":"Stempeutics Research Pvt Ltd","startDate":"2009-04","conditions":"Myocardial Infarction","enrollment":20}],"_emaApprovals":[],"_faersSignals":[],"_approvalHistory":[],"publicationCount":2,"rwe":[],"genericFilers":[],"relatedDrugs":[],"labelChanges":[],"biosimilarFilings":[],"pricing":[],"formularyStatus":[],"manufacturing":[],"companionDiagnostics":[],"competitors":[],"timeline":[],"patents":[],"ownershipHistory":[],"trials":[],"biosimilars":[],"latestUpdates":[],"references":[],"tags":[],"ecosystem":[],"genericManufacturerList":[],"offLabel":[],"developmentCodes":[],"aliases":[],"phase":"phase_2","status":"active","brandName":"Ex- vivo cultured adult allogeneic MSCs","genericName":"Ex- vivo cultured adult allogeneic MSCs","companyName":"Stempeutics Research Pvt Ltd","companyId":"stempeutics-research-pvt-ltd","modality":"Biologic","firstApprovalDate":"","aiSummary":"Ex- vivo cultured adult allogeneic MSCs are thought to exert their therapeutic effects through paracrine mechanisms, releasing various growth factors and cytokines that promote tissue repair and regeneration. Used for Osteoarthritis, Bone nonunion.","enrichmentLevel":3,"visitCount":1,"trialStats":{"total":0,"withResults":0},"verificationStatus":"verified","dataCompleteness":{"mechanism":true,"indications":true,"safety":true,"trials":true,"score":4}}