{"id":"evl-arm","safety":{"commonSideEffects":[{"rate":null,"effect":"Chest discomfort or pain"},{"rate":null,"effect":"Dysphagia"},{"rate":null,"effect":"Ulceration at ligation site"},{"rate":null,"effect":"Rebleeding"}]},"_chembl":null,"_dailymed":null,"mechanism":{"_ai_source":"claude-haiku-4.5","explanation":"EVL is an endoscopic procedure in which elastic bands are deployed around bleeding or at-risk esophageal varices to occlude blood flow and prevent variceal hemorrhage. The bands cause tissue necrosis and fibrosis, leading to variceal obliteration. This is a procedural intervention rather than a pharmacological drug.","oneSentence":"EVL (endoscopic variceal ligation) is a mechanical intervention that uses elastic bands to ligate esophageal varices and prevent bleeding.","_ai_confidence":"low"},"_scrapedAt":"2026-03-28T01:44:21.245Z","_scrapedBy":"cloudflare-swarm","_wikipedia":null,"indications":{"approved":[{"name":"Prevention and treatment of esophageal variceal bleeding in patients with portal hypertension"}]},"trialDetails":[{"nctId":"NCT06819566","phase":"PHASE2","title":"Prophylactic Endoscopic Variceal Ligation in Patients With High-risk Esophageal Varices Receiving Atezo/Bev for HCC","status":"RECRUITING","sponsor":"Asan Medical Center","startDate":"2025-05-28","conditions":"Hepatocellular Carcinoma, Esophageal Varix, Bleeding Esophageal Varices","enrollment":44},{"nctId":"NCT04936971","phase":"PHASE4","title":"Introduction of mTor Inhibitors and the Activation of the Cytomegalovirus (CMV) -Specific Cellular Immune Response","status":"WITHDRAWN","sponsor":"Edoardo Melilli","startDate":"2021-09","conditions":"Kidney Transplantation, Cytomegalovirus Infections","enrollment":""},{"nctId":"NCT01707849","phase":"PHASE3","title":"The Impact of Everolimus Based Immunosuppression in the Evolution of Hepatitis C Fibrosis After Liver Transplantation","status":"COMPLETED","sponsor":"Hospital Vall d'Hebron","startDate":"2012-10","conditions":"Hepatitis C Recurrence After Liver Transplant","enrollment":18},{"nctId":"NCT01169701","phase":"PHASE4","title":"24 Months Follow-up, Two Arm Study to Compare the Cardiovascular Profile in a Regimen With Everolimus + Mycophenolic Acid (MPA) Versus (vs.) a Regimen of CNI+MPA in Maintenance Renal Transplant Recipients","status":"COMPLETED","sponsor":"Novartis Pharmaceuticals","startDate":"2010-08","conditions":"Renal Transplant","enrollment":71},{"nctId":"NCT00863837","phase":"PHASE4","title":"Prevention of Esophageal Variceal Rebleeding","status":"UNKNOWN","sponsor":"National Science and Technology Council, Taiwan","startDate":"2006-12","conditions":"Esophageal Variceal Rebleeding","enrollment":120}],"_emaApprovals":[],"_faersSignals":[],"_approvalHistory":[],"publicationCount":12,"rwe":[],"genericFilers":[],"relatedDrugs":[],"labelChanges":[],"biosimilarFilings":[],"pricing":[],"formularyStatus":[],"manufacturing":[],"companionDiagnostics":[],"competitors":[],"timeline":[],"patents":[],"ownershipHistory":[],"trials":[],"biosimilars":[],"latestUpdates":[],"references":[],"tags":[],"ecosystem":[],"genericManufacturerList":[],"offLabel":[],"developmentCodes":[],"aliases":["Everolimus"],"phase":"phase_3","status":"active","brandName":"EVL arm","genericName":"EVL arm","companyName":"Hospital Vall d'Hebron","companyId":"hospital-vall-d-hebron","modality":"Small molecule","firstApprovalDate":"","aiSummary":"EVL (endoscopic variceal ligation) is a mechanical intervention that uses elastic bands to ligate esophageal varices and prevent bleeding. Used for Prevention and treatment of esophageal variceal bleeding in patients with portal hypertension.","enrichmentLevel":3,"visitCount":1,"trialStats":{"total":0,"withResults":0},"verificationStatus":"verified","dataCompleteness":{"mechanism":true,"indications":true,"safety":true,"trials":true,"score":4}}