{"id":"ev71-vaccine-and-influenza-vaccine","safety":{"commonSideEffects":[{"rate":null,"effect":"Injection site pain, redness, or swelling"},{"rate":null,"effect":"Fever"},{"rate":null,"effect":"Myalgia"},{"rate":null,"effect":"Fatigue"}]},"_chembl":null,"_dailymed":null,"mechanism":{"_ai_source":"claude-haiku-4.5","explanation":"EV71 vaccine contains inactivated enterovirus 71 virus particles that trigger humoral and cell-mediated immune responses to prevent EV71 infection, which causes hand-foot-and-mouth disease. The influenza vaccine component provides protection against seasonal influenza strains through similar immunogenic mechanisms. The combination allows simultaneous protection against both pathogens in a single administration.","oneSentence":"This is a combination vaccine that stimulates the immune system to produce antibodies and cellular immunity against enterovirus 71 (EV71) and influenza viruses.","_ai_confidence":"medium"},"_scrapedAt":"2026-03-28T00:36:02.985Z","_scrapedBy":"cloudflare-swarm","_wikipedia":null,"indications":{"approved":[{"name":"Prevention of enterovirus 71 (EV71) infection and hand-foot-and-mouth disease"},{"name":"Prevention of seasonal influenza"}]},"trialDetails":[{"nctId":"NCT04091880","phase":"PHASE4","title":"Evaluation of the Safety and Immunogenicity of Simultaneously Administration of EV71 Vaccine and Influenza Vaccine","status":"COMPLETED","sponsor":"China National Biotec Group Company Limited","startDate":"2019-09-26","conditions":"Enterovirus Infections, Influenza","enrollment":1134},{"nctId":"NCT04133584","phase":"PHASE4","title":"The Immunogenicity and Safety of the Vaccination of Inactivated Enterovirus 71 Vaccine and Seasonal Influenza Vaccine","status":"COMPLETED","sponsor":"Zhejiang Provincial Center for Disease Control and Prevention","startDate":"2019-09-16","conditions":"Seasonal Influenza, Hand, Foot and Mouth Disease","enrollment":1134},{"nctId":"NCT05166044","phase":"","title":"Safety Observation of Enterovirus 71 Inactivated Vaccine (Vero Cell) Combined Immunization in Shanghai","status":"UNKNOWN","sponsor":"Sinovac Biotech Co., Ltd","startDate":"2022-01-04","conditions":"Hand, Foot and Mouth Disease","enrollment":12500}],"_emaApprovals":[],"_faersSignals":[],"_approvalHistory":[],"publicationCount":0,"rwe":[],"genericFilers":[],"relatedDrugs":[],"labelChanges":[],"biosimilarFilings":[],"pricing":[],"formularyStatus":[],"manufacturing":[],"companionDiagnostics":[],"competitors":[],"timeline":[],"patents":[],"ownershipHistory":[],"trials":[],"biosimilars":[],"latestUpdates":[],"references":[],"tags":[],"ecosystem":[],"genericManufacturerList":[],"offLabel":[],"developmentCodes":[],"aliases":[],"phase":"marketed","status":"active","brandName":"EV71 vaccine and influenza vaccine","genericName":"EV71 vaccine and influenza vaccine","companyName":"China National Biotec Group Company Limited","companyId":"china-national-biotec-group-company-limited","modality":"Biologic","firstApprovalDate":"","aiSummary":"This is a combination vaccine that stimulates the immune system to produce antibodies and cellular immunity against enterovirus 71 (EV71) and influenza viruses. Used for Prevention of enterovirus 71 (EV71) infection and hand-foot-and-mouth disease, Prevention of seasonal influenza.","enrichmentLevel":3,"visitCount":1,"trialStats":{"total":1,"withResults":0},"verificationStatus":"verified","dataCompleteness":{"mechanism":true,"indications":true,"safety":true,"trials":true,"score":4}}