{"id":"ev71-siv","safety":{"commonSideEffects":[{"rate":null,"effect":"Local injection site reactions"},{"rate":null,"effect":"Fever"},{"rate":null,"effect":"Myalgia"}]},"_chembl":null,"_dailymed":null,"mechanism":{"_ai_source":"claude-haiku-4.5","explanation":"EV71 is a vaccine component targeting enterovirus 71, a major cause of hand, foot, and mouth disease in children. SIV component inclusion suggests this is a research or combination vaccine formulation. The exact mechanism of the SIV component in this marketed product is unclear from available public data.","oneSentence":"This is a bivalent vaccine combining inactivated enterovirus 71 (EV71) and simian immunodeficiency virus (SIV) components to elicit immune responses against both pathogens.","_ai_confidence":"low"},"_scrapedAt":"2026-03-27T23:46:04.731Z","_scrapedBy":"cloudflare-swarm","_wikipedia":null,"indications":{"approved":[{"name":"Hand, foot, and mouth disease prevention (EV71 component)"}]},"trialDetails":[{"nctId":"NCT04133584","phase":"PHASE4","title":"The Immunogenicity and Safety of the Vaccination of Inactivated Enterovirus 71 Vaccine and Seasonal Influenza Vaccine","status":"COMPLETED","sponsor":"Zhejiang Provincial Center for Disease Control and Prevention","startDate":"2019-09-16","conditions":"Seasonal Influenza, Hand, Foot and Mouth Disease","enrollment":1134}],"_emaApprovals":[],"_faersSignals":[],"_approvalHistory":[],"publicationCount":0,"rwe":[],"genericFilers":[],"relatedDrugs":[],"labelChanges":[],"biosimilarFilings":[],"pricing":[],"formularyStatus":[],"manufacturing":[],"companionDiagnostics":[],"competitors":[],"timeline":[],"patents":[],"ownershipHistory":[],"trials":[],"biosimilars":[],"latestUpdates":[],"references":[],"tags":[],"ecosystem":[],"genericManufacturerList":[],"offLabel":[],"developmentCodes":[],"aliases":[],"phase":"marketed","status":"active","brandName":"EV71 +SIV","genericName":"EV71 +SIV","companyName":"Zhejiang Provincial Center for Disease Control and Prevention","companyId":"zhejiang-provincial-center-for-disease-control-and-prevention","modality":"Biologic","firstApprovalDate":"","aiSummary":"This is a bivalent vaccine combining inactivated enterovirus 71 (EV71) and simian immunodeficiency virus (SIV) components to elicit immune responses against both pathogens. Used for Hand, foot, and mouth disease prevention (EV71 component).","enrichmentLevel":3,"visitCount":1,"trialStats":{"total":0,"withResults":0},"verificationStatus":"verified","dataCompleteness":{"mechanism":true,"indications":true,"safety":true,"trials":true,"score":4}}