{"id":"ev71-inactived-vaccine-vero-cells","safety":{"commonSideEffects":[{"rate":null,"effect":"Injection site pain, redness, or swelling"},{"rate":null,"effect":"Fever"},{"rate":null,"effect":"Irritability or fussiness"},{"rate":null,"effect":"Loss of appetite"}]},"_chembl":null,"_dailymed":null,"mechanism":{"_ai_source":"claude-haiku-4.5","explanation":"The vaccine contains chemically inactivated EV71 virus particles grown in Vero cells (monkey kidney cells). Upon intramuscular injection, the inactivated viral antigens trigger both humoral (antibody) and cell-mediated immune responses, priming the immune system to recognize and neutralize live EV71 virus upon natural exposure. This prevents or reduces the severity of hand, foot, and mouth disease (HFMD) and other EV71-associated complications.","oneSentence":"This inactivated virus vaccine stimulates the immune system to produce antibodies and cellular immunity against enterovirus 71 (EV71) to prevent infection and disease.","_ai_confidence":"high"},"_scrapedAt":"2026-03-28T00:36:02.946Z","_scrapedBy":"cloudflare-swarm","_wikipedia":null,"indications":{"approved":[{"name":"Prevention of hand, foot, and mouth disease (HFMD) caused by enterovirus 71"},{"name":"Prevention of EV71-associated neurological complications in infants and young children"}]},"trialDetails":[{"nctId":"NCT03873740","phase":"PHASE4","title":"Immunogenicity and Safety of Two Different Commercial EV71 Vaccines","status":"COMPLETED","sponsor":"Sinovac Biotech Co., Ltd","startDate":"2018-11-06","conditions":"Hand, Foot and Mouth Disease","enrollment":300}],"_emaApprovals":[],"_faersSignals":[],"_approvalHistory":[],"publicationCount":0,"rwe":[],"genericFilers":[],"relatedDrugs":[],"labelChanges":[],"biosimilarFilings":[],"pricing":[],"formularyStatus":[],"manufacturing":[],"companionDiagnostics":[],"competitors":[],"timeline":[],"patents":[],"ownershipHistory":[],"trials":[],"biosimilars":[],"latestUpdates":[],"references":[],"tags":[],"ecosystem":[],"genericManufacturerList":[],"offLabel":[],"developmentCodes":[],"aliases":[],"phase":"marketed","status":"active","brandName":"EV71 inactived vaccine（Vero cells）","genericName":"EV71 inactived vaccine（Vero cells）","companyName":"Sinovac Biotech Co., Ltd","companyId":"sinovac-biotech-co-ltd","modality":"Biologic","firstApprovalDate":"","aiSummary":"This inactivated virus vaccine stimulates the immune system to produce antibodies and cellular immunity against enterovirus 71 (EV71) to prevent infection and disease. Used for Prevention of hand, foot, and mouth disease (HFMD) caused by enterovirus 71, Prevention of EV71-associated neurological complications in infants and young children.","enrichmentLevel":3,"visitCount":0,"trialStats":{"total":1,"withResults":0},"verificationStatus":"verified","dataCompleteness":{"mechanism":true,"indications":true,"safety":true,"trials":true,"score":4}}