{"id":"euvichol-s-oral-cholera-vaccine","safety":{"commonSideEffects":[{"rate":null,"effect":"Abdominal discomfort or cramping"},{"rate":null,"effect":"Diarrhea"},{"rate":null,"effect":"Nausea"},{"rate":null,"effect":"Vomiting"},{"rate":null,"effect":"Fever"}]},"_chembl":null,"_dailymed":null,"mechanism":{"_ai_source":"claude-haiku-4.5","explanation":"The vaccine contains live attenuated (weakened) strains of Vibrio cholerae O1 and O139 that replicate in the intestinal tract, triggering both local intestinal IgA antibody production and systemic immune responses. This mucosal immunization approach provides protection against cholera infection by preventing bacterial colonization and toxin-mediated disease in the small intestine.","oneSentence":"Euvichol-S is a live attenuated oral cholera vaccine that stimulates mucosal and systemic immune responses against Vibrio cholerae.","_ai_confidence":"medium"},"_scrapedAt":"2026-03-27T23:46:02.736Z","_scrapedBy":"cloudflare-swarm","_wikipedia":null,"indications":{"approved":[{"name":"Prevention of cholera caused by Vibrio cholerae O1 and O139 in endemic and epidemic areas"}]},"trialDetails":[{"nctId":"NCT07487077","phase":"PHASE4","title":"Extended Dosing Intervals Trial for Oral Cholera Vaccine, Kenya","status":"RECRUITING","sponsor":"Albert B. Sabin Vaccine Institute","startDate":"2025-10-31","conditions":"Cholera Vaccination","enrollment":1071},{"nctId":"NCT07304284","phase":"PHASE3","title":"Trial to Evaluate Immunogenicity Non-Inferiority, Safety and Lot-to-Lot Consistency of Biovac OCV-S to Euvichol®-Plus","status":"RECRUITING","sponsor":"International Vaccine Institute","startDate":"2025-10-31","conditions":"Cholera Vaccination","enrollment":2824}],"_emaApprovals":[],"_faersSignals":[],"_approvalHistory":[],"publicationCount":1,"rwe":[],"genericFilers":[],"relatedDrugs":[],"labelChanges":[],"biosimilarFilings":[],"pricing":[],"formularyStatus":[],"manufacturing":[],"companionDiagnostics":[],"competitors":[],"timeline":[],"patents":[],"ownershipHistory":[],"trials":[],"biosimilars":[],"latestUpdates":[],"references":[],"tags":[],"ecosystem":[],"genericManufacturerList":[],"offLabel":[],"developmentCodes":[],"aliases":["cholera: inactivated oral","Euvichol"],"phase":"marketed","status":"active","brandName":"Euvichol-S Oral Cholera Vaccine","genericName":"Euvichol-S Oral Cholera Vaccine","companyName":"Albert B. Sabin Vaccine Institute","companyId":"albert-b-sabin-vaccine-institute","modality":"Small molecule","firstApprovalDate":"","aiSummary":"Euvichol-S is a live attenuated oral cholera vaccine that stimulates mucosal and systemic immune responses against Vibrio cholerae. Used for Prevention of cholera caused by Vibrio cholerae O1 and O139 in endemic and epidemic areas.","enrichmentLevel":3,"visitCount":0,"trialStats":{"total":0,"withResults":0},"verificationStatus":"verified","dataCompleteness":{"mechanism":true,"indications":true,"safety":true,"trials":true,"score":4}}