{"id":"eugenol","rwe":[],"tags":[{"label":"Standardized Chemical Allergen","category":"class"},{"label":"Small Molecule","category":"modality"},{"label":"Prostaglandin G/H synthase 1","category":"target"},{"label":"PTGS1","category":"gene"},{"label":"ALOX5","category":"gene"},{"label":"Topical","category":"route"},{"label":"Dental","category":"route"},{"label":"Oral","category":"route"},{"label":"Cream","category":"form"},{"label":"Gel","category":"form"},{"label":"Liquid","category":"form"},{"label":"Ointment","category":"form"},{"label":"Active","category":"status"},{"label":"HITEC-Institute of Medical Sciences","category":"company"},{"label":"Anti-Infective Agents","category":"pharmacology"},{"label":"Solvents","category":"pharmacology"}],"phase":"marketed","safety":{},"trials":[],"aliases":[],"company":"HITEC-Institute of Medical Sciences","patents":[],"pricing":[],"allNames":"bioxeda","offLabel":[],"synonyms":["eugenol","allylguaiacol","bioxeda","caryophyllic acid","dentogum","eugenic acid"],"timeline":[],"aiSummary":"Bioxeda, also known as Eugenol, is a standardized chemical allergen developed by HITEC-Institute of Medical Sciences. It targets Prostaglandin G/H synthase 1, a key enzyme involved in inflammation. However, its commercial status and approved indications are unknown. As a small molecule, Bioxeda's mechanism of action and pharmacokinetic properties are not well-documented. Further research is needed to understand its potential therapeutic applications and safety considerations.","approvals":[{"date":"","orphan":false,"company":"","regulator":"FDA"}],"brandName":"Bioxeda","ecosystem":[],"mechanism":{"target":"Arachidonate 5-lipoxygenase, Prostaglandin G/H synthase 1","novelty":"First-in-class","targets":[{"gene":"PTGS1","source":"DrugCentral","target":"Prostaglandin G/H synthase 1","protein":"Prostaglandin G/H synthase 1"},{"gene":"ALOX5","source":"DrugCentral","target":"Arachidonate 5-lipoxygenase","protein":"Arachidonate 5-lipoxygenase"}],"modality":"Small Molecule","drugClass":"Standardized Chemical Allergen","explanation":"Think of it like a fire alarm in a building. Prostaglandin G/H synthase 1 is like the alarm that sounds when there's a fire, triggering an inflammatory response. Bioxeda is like a fire extinguisher that puts out the alarm, reducing inflammation.","oneSentence":"Bioxeda works by binding to and inhibiting the enzyme Prostaglandin G/H synthase 1, which plays a key role in the production of inflammatory mediators.","technicalDetail":"Bioxeda exerts its anti-inflammatory effects by competitively inhibiting the cyclooxygenase (COX) activity of Prostaglandin G/H synthase 1, thereby reducing the production of prostaglandins and thromboxanes."},"commercial":{},"references":[{"id":1,"url":"https://drugcentral.org/drugcard/4648","fields":["approvals","synonyms","ATC","PK","indications","contraindications","DDIs","targets","patents","FAERS"],"source":"DrugCentral"},{"id":2,"url":"https://clinicaltrials.gov/search?intr=Eugenol","fields":["trials"],"source":"ClinicalTrials.gov"},{"id":3,"url":"https://pubmed.ncbi.nlm.nih.gov/?term=Eugenol","fields":["publications"],"source":"PubMed/NCBI"}],"_enrichedAt":"2026-03-30T11:23:37.318035","biosimilars":[],"competitors":[{"drugName":"acetylsalicylic acid","drugSlug":"acetylsalicylic-acid","fdaApproval":"1950-04-12","relationship":"same-target"},{"drugName":"balsalazide","drugSlug":"balsalazide","fdaApproval":"2000-07-18","patentExpiry":"Jun 23, 2031","patentStatus":"Patent protected","relationship":"same-target"},{"drugName":"bromfenac","drugSlug":"bromfenac","fdaApproval":"2005-03-24","patentExpiry":"Nov 19, 2032","patentStatus":"Patent protected","relationship":"same-target"},{"drugName":"capsaicin","drugSlug":"capsaicin","fdaApproval":"2009-11-16","patentExpiry":"Mar 26, 2030","patentStatus":"Patent protected","relationship":"same-target"},{"drugName":"captopril","drugSlug":"captopril","fdaApproval":"1981-04-06","genericCount":21,"patentStatus":"Off-patent — generic available","relationship":"same-target"},{"drugName":"carprofen","drugSlug":"carprofen","fdaApproval":"1987-12-31","patentStatus":"Unknown","relationship":"same-target"},{"drugName":"celecoxib","drugSlug":"celecoxib","fdaApproval":"1998-12-31","patentExpiry":"May 27, 2036","patentStatus":"Patent protected","relationship":"same-target"},{"drugName":"cianidanol","drugSlug":"cianidanol","fdaApproval":"","relationship":"same-target"},{"drugName":"clomifene","drugSlug":"clomifene","fdaApproval":"1967-02-01","relationship":"same-target"},{"drugName":"deracoxib","drugSlug":"deracoxib","fdaApproval":"","relationship":"same-target"}],"dataSources":[{"url":"https://drugcentral.org","name":"DrugCentral","fields":["indications","contraindications","safety","target","drugInteractions"],"retrievedDate":"2026-04-07"}],"genericName":"eugenol","indications":{"approved":[],"offLabel":[],"pipeline":[]},"drugCategory":"active","labelChanges":[],"relatedDrugs":[{"drugId":"acetylsalicylic-acid","brandName":"acetylsalicylic acid","genericName":"acetylsalicylic acid","approvalYear":"1950","relationship":"same-target"},{"drugId":"balsalazide","brandName":"balsalazide","genericName":"balsalazide","approvalYear":"2000","relationship":"same-target"},{"drugId":"bromfenac","brandName":"bromfenac","genericName":"bromfenac","approvalYear":"2005","relationship":"same-target"},{"drugId":"capsaicin","brandName":"capsaicin","genericName":"capsaicin","approvalYear":"2009","relationship":"same-target"},{"drugId":"captopril","brandName":"captopril","genericName":"captopril","approvalYear":"1981","relationship":"same-target"},{"drugId":"carprofen","brandName":"carprofen","genericName":"carprofen","approvalYear":"1987","relationship":"same-target"},{"drugId":"celecoxib","brandName":"celecoxib","genericName":"celecoxib","approvalYear":"1998","relationship":"same-target"},{"drugId":"cianidanol","brandName":"cianidanol","genericName":"cianidanol","approvalYear":"","relationship":"same-target"},{"drugId":"clomifene","brandName":"clomifene","genericName":"clomifene","approvalYear":"1967","relationship":"same-target"},{"drugId":"deracoxib","brandName":"deracoxib","genericName":"deracoxib","approvalYear":"","relationship":"same-target"}],"trialDetails":[{"nctId":"NCT07475364","phase":"PHASE1,PHASE2","title":"Lesion Sterilization and Tissue Repair Antibiotic Paste Versus Zinc Oxide and Eugenol Pulpectomy for Treatment of Primary Molars With Pulp Necrosis","status":"NOT_YET_RECRUITING","sponsor":"University of Faisalabad","startDate":"2026-05-01","conditions":["Pulp Necrosis"],"enrollment":180,"completionDate":"2027-05-01"},{"nctId":"NCT07475663","phase":"PHASE3","title":"Counterpain PXM Versus Diclofenac Versus Piroxicam","status":"COMPLETED","sponsor":"Taisho Pharmaceutical Indonesia","startDate":"2025-11-04","conditions":["Ankle Sprain","Back Pain","Osteoarthritis (OA) of the Knee","Tennis Elbow","Runner's Knee"],"enrollment":180,"completionDate":"2026-02-12"},{"nctId":"NCT05336682","phase":"NA","title":"Evaluation of Lesion Sterilization and Tissue Repair Techniques Versus Pulpectomy in Primary Molars With Inflammed Pulp","status":"COMPLETED","sponsor":"Cairo University","startDate":"2022-09-20","conditions":["Pulpitis - Irreversible"],"enrollment":66,"completionDate":"2025-05-30"},{"nctId":"NCT07437794","phase":"NA","title":"Clinical and Radiographic Assessment of Neo Putty MTA Versus Formocresol Used in Vital Pulpotomy of Mandibular Primary Molars","status":"NOT_YET_RECRUITING","sponsor":"October University for Modern Sciences and Arts","startDate":"2026-03-01","conditions":["Deep Caries in Primary Molars"],"enrollment":68,"completionDate":"2026-05-01"},{"nctId":"NCT07424053","phase":"NA","title":"Effect of Graphene Oxide on Vital and Non-Vital Primary Teeth Compared to the Conventional Techniques","status":"NOT_YET_RECRUITING","sponsor":"Al-Azhar University","startDate":"2026-04","conditions":["Primary Teeth Indicated for Pulp Therapy"],"enrollment":126,"completionDate":"2026-12-01"},{"nctId":"NCT07395401","phase":"NA","title":"Evaluation of Zinc Oxide Eugenol and Iodoform-Calcium Hydroxide as Filling Materials in Primary Molar Root Canals Prepared by Rotary and Manual Files","status":"RECRUITING","sponsor":"October University for Modern Sciences and Arts","startDate":"2026-02-15","conditions":["Carious Primary Molars Indicated for Pulpectomy"],"enrollment":44,"completionDate":"2026-03-15"},{"nctId":"NCT07343804","phase":"NA","title":"THE EFFECT OF ENDODONTIC TREATMENT ON CARDIOVASCULAR RISK BIOMARKERS IN PATIENTS WITH STABLE CORONARY ARTERY DISEASE","status":"RECRUITING","sponsor":"Postgraduate Institute of Dental Sciences Rohtak","startDate":"2025-11-01","conditions":["Cardiovascular Disease Risk Factor","Periapical Periodontitis"],"enrollment":80,"completionDate":"2026-03"},{"nctId":"NCT06293521","phase":"PHASE2","title":"Clinical and Radiographic Success Rate of Pulpotomy Versus Pulpectomy for Management of Primary Teeth With Deep Caries","status":"RECRUITING","sponsor":"Cairo University","startDate":"2026-01-01","conditions":["Deep Caries"],"enrollment":40,"completionDate":"2026-04-01"},{"nctId":"NCT07151703","phase":"PHASE3","title":"Topical Versus Injection PRP for Olfactory Dysfunction","status":"NOT_YET_RECRUITING","sponsor":"Taipei Veterans General Hospital, Taiwan","startDate":"2025-10-01","conditions":["Olfactory Dysfunction","Anosmia","Hyposmia"],"enrollment":60,"completionDate":"2028-12-31"},{"nctId":"NCT05448937","phase":"PHASE2,PHASE3","title":"Lesion Sterilization And Tissue Repair Versus Zinc Oxide And Eugenol For Treatment of Necrotic Primary Molars","status":"COMPLETED","sponsor":"Cairo University","startDate":"2022-10-01","conditions":["Necrotic Primary Molars"],"enrollment":60,"completionDate":"2025-03-08"},{"nctId":"NCT04374474","phase":"PHASE4","title":"Anosmia Rehabilitation in Patients Post Coronavirus Disease (COVID 19)","status":"WITHDRAWN","sponsor":"London Health Sciences Centre Research Institute OR Lawson Research Institute of St. Joseph's","startDate":"2021-01-10","conditions":["Olfactory Disorder"],"enrollment":0,"completionDate":"2022-03-10"},{"nctId":"NCT07090252","phase":"NA","title":"Comparison of ZOE vs ZON in Primary Mandibular Molars Pulpectomy of 5-7-Year-Olds","status":"NOT_YET_RECRUITING","sponsor":"Cairo University","startDate":"2025-09-01","conditions":["Carious Primary Molars"],"enrollment":24,"completionDate":"2026-11-01"},{"nctId":"NCT03441074","phase":"NA","title":"Olfactory Function and Delayed Neurocognitive Recovery","status":"COMPLETED","sponsor":"Shanghai 10th People's Hospital","startDate":"2018-01-01","conditions":["Delayed Neurocognitive Recovery"],"enrollment":131,"completionDate":"2022-12-31"},{"nctId":"NCT07070024","phase":"PHASE1,PHASE2","title":"Efficacy of Microneedling With Vitamin C in Performing Gingival Depigmentation","status":"NOT_YET_RECRUITING","sponsor":"Fayoum University","startDate":"2025-07","conditions":["Gingival Pigmentation"],"enrollment":30,"completionDate":"2026-12"},{"nctId":"NCT04942158","phase":"NA","title":"Non-instrumentation Root Canal Treatment of Primary Molars","status":"COMPLETED","sponsor":"University of Sao Paulo","startDate":"2021-10-04","conditions":["Dental Pulp Diseases","Dental Pulp Necrosis"],"enrollment":180,"completionDate":"2025-04-30"},{"nctId":"NCT04962607","phase":"","title":"Effectiveness of Premixed Bioactive Bioceramic MTA (Neo-Putty®) in Pulpotomies Primary Teeth","status":"ACTIVE_NOT_RECRUITING","sponsor":"Hadassah Medical Organization","startDate":"2021-09-01","conditions":["Pulpotomies on Primary Molars"],"enrollment":50,"completionDate":"2026-01-01"},{"nctId":"NCT05739682","phase":"NA","title":"Pain and Microbial Reduction of Antimicrobial Corticosteroid Mixture Versus Cryotherapy in Necrotic Teeth","status":"COMPLETED","sponsor":"Cairo University","startDate":"2024-07-01","conditions":["Dental Pulp Necrosis"],"enrollment":28,"completionDate":"2025-02-09"},{"nctId":"NCT05937100","phase":"NA","title":"New Vital Pulpotomy Medications in Primary Molars","status":"ACTIVE_NOT_RECRUITING","sponsor":"Mansoura University","startDate":"2023-05-01","conditions":["Carious Exposure of Pulp"],"enrollment":48,"completionDate":"2025-08-01"},{"nctId":"NCT06975761","phase":"PHASE2","title":"Postoperative Pain Comparison of Two Root Canal Sealers in Irreversible Pulpitis","status":"RECRUITING","sponsor":"Armed Forces Institute of Dentistry, Pakistan","startDate":"2025-04-07","conditions":["Post Operative Pain After Root Canal Therapy"],"enrollment":62,"completionDate":"2025-08-07"},{"nctId":"NCT05855369","phase":"PHASE2,PHASE3","title":"Study of Chemosensory Enhancement Through Neuromodulation Training (SCENT for Long COVID)","status":"RECRUITING","sponsor":"Medical University of South Carolina","startDate":"2023-10-02","conditions":["Smell Dysfunction","Olfactory Disorder","Long COVID"],"enrollment":180,"completionDate":"2028-05-31"},{"nctId":"NCT04885686","phase":"NA","title":"Endodontic Post-operative Pain Evaluation of Patients After Using Endomethasone N or Endomethasone SP (EndoPOP)","status":"COMPLETED","sponsor":"Septodont","startDate":"2021-06-22","conditions":["Root Canal Obturation"],"enrollment":300,"completionDate":"2022-06-11"},{"nctId":"NCT05464914","phase":"NA","title":"Post Extraction Wound Healing Evaluation of Immediate Complete Denture Using IPR Scale","status":"COMPLETED","sponsor":"Badr University","startDate":"2024-08-01","conditions":["Complete Edentulism Due to Periodontal Disease (Disorder)"],"enrollment":12,"completionDate":"2025-02-01"},{"nctId":"NCT06871709","phase":"NA","title":"Clinical and Radiographic Evaluation of Potassium Nitrate in Polycarboxylate Versus Mineral Trioxide Aggregate in Vital Pulpotomy in Primary Molars","status":"NOT_YET_RECRUITING","sponsor":"Cairo University","startDate":"2025-05-30","conditions":["Vital Pulp Therapies","Pulpotomy","Pulp Disease, Dental","Pulpotomies Primary Teeth","Pulp Therapy"],"enrollment":50,"completionDate":"2026-12-30"},{"nctId":"NCT06865508","phase":"NA","title":"Photo Biomodulation Therapy for Alveolar Osteitis Recovery in Oral Contraceptive Users","status":"COMPLETED","sponsor":"Badr University","startDate":"2023-11-01","conditions":["Alveolar Osteitis"],"enrollment":50,"completionDate":"2024-12-30"},{"nctId":"NCT05557812","phase":"EARLY_PHASE1","title":"A Clinical Trial Comparing FS With ZOE and Non-eugenol Based Materials in Primary Teeth Pulpotomies","status":"COMPLETED","sponsor":"Virginia Commonwealth University","startDate":"2023-02-02","conditions":["Pulpitis"],"enrollment":19,"completionDate":"2025-02-01"},{"nctId":"NCT06837051","phase":"NA","title":"The Effect of Modified Olfactory Training on Postoperative Olfactory Dysfunction in Patients With CRS","status":"NOT_YET_RECRUITING","sponsor":"Peking University Third Hospital","startDate":"2025-03-14","conditions":["Olfactory Dysfunction","Chronic Rhinosinusitis"],"enrollment":213,"completionDate":"2027-03-14"},{"nctId":"NCT06829706","phase":"NA","title":"The Efficacy of Modified Olfactory Training Method for Patients With Post-viral Olfactory Dysfunction","status":"RECRUITING","sponsor":"Peking University Third Hospital","startDate":"2025-03-22","conditions":["Olfactory Dysfunction","Post Viral Olfactory Dysfunction (PVOD)"],"enrollment":150,"completionDate":"2027-05-22"},{"nctId":"NCT06823544","phase":"PHASE2","title":"A Comparative Single Blind Clinical Study on the Effect of Alvogyl, Eugenol, and Nigella Sativa (Black Seed Oil) for Alveolar Osteitis.","status":"NOT_YET_RECRUITING","sponsor":"HITEC-Institute of Medical Sciences","startDate":"2025-02-01","conditions":["Alveolar Osteitis"],"enrollment":40,"completionDate":"2025-08-31"},{"nctId":"NCT06821828","phase":"NA","title":"The Efficacy of Modified Olfactory Training for MCI High-Risk Individuals","status":"NOT_YET_RECRUITING","sponsor":"Peking University Third Hospital","startDate":"2025-03-22","conditions":["Subjective Cognitive Decline (SCD)","Olfactory Dysfunction","Mild Cognitive Impairment (MCI)","ELDERLY PEOPLE"],"enrollment":114,"completionDate":"2027-05-22"},{"nctId":"NCT06809478","phase":"NA","title":"Clinical and Radiographic Evaluation of Chitosan Versus Formocresol After Vital Pulpotomy of Primary Molars","status":"NOT_YET_RECRUITING","sponsor":"Cairo University","startDate":"2025-04","conditions":["Pulpitis - Reversible","Pulpotomy"],"enrollment":50,"completionDate":"2026-07"},{"nctId":"NCT06782035","phase":"NA","title":"The Effect of Periodontal Dressings and Various Materials on the Donor Site's Quality of Life After Free Gingival Graft Surgery","status":"RECRUITING","sponsor":"Izmir Katip Celebi University","startDate":"2025-01-02","conditions":["Recession, Gingival"],"enrollment":36,"completionDate":"2025-05-25"},{"nctId":"NCT06752889","phase":"NA","title":"Clinical and Radiographic Evaluation of Zinc Oxide Modified 3Mixtatin Versus Zical in Root Canal Treatment of Necrotic Primary Molars.","status":"RECRUITING","sponsor":"Ain Shams University","startDate":"2024-01-01","conditions":["Necrotic Pulp","Primary Teeth"],"enrollment":34,"completionDate":"2025-02"},{"nctId":"NCT06751316","phase":"NA","title":"Clinical and Radiographic Evaluation of MTA Pulpotomy Versus Conventional Pulpectomy in Primary Molars With Irreversible Pulpitis","status":"NOT_YET_RECRUITING","sponsor":"Cairo University","startDate":"2025-01-01","conditions":["Decayed Primary Molars With Irreversible Pulpitis"],"enrollment":42,"completionDate":"2026-01-01"},{"nctId":"NCT06288477","phase":"NA","title":"Clinical and Radiographic Evaluation of Vital Pulpotomy Techniques in Primary Molars Using of Premixed Bioactive Bioceramic MTA (Neo-putty) as a Novel Pulpotomy Medication Versus Formocresol","status":"RECRUITING","sponsor":"October University for Modern Sciences and Arts","startDate":"2024-03-20","conditions":["Vital","Pulpotomy","Techniques"],"enrollment":44,"completionDate":"2025-02-01"},{"nctId":"NCT05384561","phase":"NA","title":"Olfactory Training As a Treatment for Olfactory Dysfunction Post COVID-19","status":"RECRUITING","sponsor":"Université du Québec à Trois-Rivières","startDate":"2022-05-31","conditions":["Hyposmia","COVID-19","Parosmia","Anosmia","SARS-CoV-2 Infection"],"enrollment":70,"completionDate":"2025-09"},{"nctId":"NCT06456060","phase":"PHASE1","title":"Efficacy of Pure Honey Dressing in Contrast to Alvogyl in the Resolution of Dry Socket","status":"RECRUITING","sponsor":"Watim Medical & Dental College","startDate":"2024-06-01","conditions":["Dry Socket"],"enrollment":40,"completionDate":"2025-01-30"},{"nctId":"NCT06482593","phase":"PHASE4","title":"Periapical Healing in Response to Endodontically Treated Teeth With Different Sealing Cement","status":"ACTIVE_NOT_RECRUITING","sponsor":"Institucion Universitaria Colegios de Colombia","startDate":"2023-08-01","conditions":["Apical Periodontitis"],"enrollment":72,"completionDate":"2024-09-30"},{"nctId":"NCT06424353","phase":"NA","title":"Postoperative Pain After Pulpectomy of Primary Molars","status":"RECRUITING","sponsor":"Minia University","startDate":"2024-01-20","conditions":["Postoperative Pain"],"enrollment":100,"completionDate":"2024-06"},{"nctId":"NCT06400277","phase":"NA","title":"In-Vivo Comparison of Different Impression Methods in Complete Edentulous Upper Jaw","status":"COMPLETED","sponsor":"Hacettepe University","startDate":"2022-07-30","conditions":["Edentulous Jaw"],"enrollment":15,"completionDate":"2024-03-27"},{"nctId":"NCT06398327","phase":"NA","title":"Efficacy Of Proinflammatory Cytokines in The Primary Molar Pulpotomy","status":"COMPLETED","sponsor":"Ataturk University","startDate":"2021-11-05","conditions":["Pulp Disease, Dental"],"enrollment":75,"completionDate":"2023-05-17"},{"nctId":"NCT06366568","phase":"PHASE3","title":"Efficacy of a Eugenol-based Product to Improve the Quality of Toothbrushing and Relieving Gum Discomfort Areas","status":"COMPLETED","sponsor":"Colgate Palmolive","startDate":"2024-02-19","conditions":["Plaque, Dental"],"enrollment":86,"completionDate":"2024-03-06"},{"nctId":"NCT06313905","phase":"NA","title":"EVADRY® in the Treatment of Xerostomia in Sjögren's Syndrome","status":"NOT_YET_RECRUITING","sponsor":"University Tunis El Manar","startDate":"2024-04-15","conditions":["Sjogren's Syndrome"],"enrollment":180,"completionDate":"2025-12-31"},{"nctId":"NCT06107595","phase":"NA","title":"Conditioned Open Label Placebo for Postoperative Pain Management","status":"UNKNOWN","sponsor":"Centre de Médecine Intégrative et Complémentaire (CEMIC)","startDate":"2024-01-08","conditions":["Pain, Postoperative"],"enrollment":222,"completionDate":"2025-12"},{"nctId":"NCT04914325","phase":"PHASE4","title":"Patient Satisfaction , Marginal Adaptation And Biocompatibility of Milled Biohpp Polyetheretherketone (PEEK) Single Anterior Crowns Veneered With Two Different Techniques.","status":"COMPLETED","sponsor":"Cairo University","startDate":"2021-10-22","conditions":["Patient Satisfaction","Gingival Bleeding"],"enrollment":32,"completionDate":"2024-01-22"},{"nctId":"NCT06166316","phase":"NA","title":"Effect of Implant Position on Clinical Outcomes","status":"COMPLETED","sponsor":"Mansoura University","startDate":"2020-01-10","conditions":["Bone Loss","Patient Satisfaction"],"enrollment":36,"completionDate":"2023-10-01"},{"nctId":"NCT05633537","phase":"NA","title":"Clinical & Radiographic Evaluation of Zinc Oxide-Ozonated Oil as a New Primary Root Canal Filling","status":"COMPLETED","sponsor":"Tanta University","startDate":"2021-07-04","conditions":["Pulp Disease, Dental","Obturation","Root Canal Infection"],"enrollment":90,"completionDate":"2023-05-29"},{"nctId":"NCT06151665","phase":"NA","title":"Single Rotary File System Versus Conventional Manual K-file in Pulpectomy of Primary Molars.","status":"UNKNOWN","sponsor":"Ain Shams University","startDate":"2023-12-01","conditions":["Endodontically Treated Teeth"],"enrollment":30,"completionDate":"2024-12-01"},{"nctId":"NCT04945993","phase":"","title":"Tooth Retention After Root Canal Treatment With Endomethasone N","status":"ACTIVE_NOT_RECRUITING","sponsor":"Septodont","startDate":"2021-07-02","conditions":["Dental Root Canal Obturation"],"enrollment":179,"completionDate":"2026-12-21"},{"nctId":"NCT06144983","phase":"PHASE4","title":"Chlorhexidine Gel Versus Alvogyl Following Surgical Extraction of Impacted Mandibular Third Molar","status":"COMPLETED","sponsor":"University of Baghdad","startDate":"2022-02-01","conditions":["Impacted Third Molar Tooth"],"enrollment":51,"completionDate":"2022-09-01"},{"nctId":"NCT06066307","phase":"PHASE4","title":"Olfactory Performance in Culinary Arts Students","status":"UNKNOWN","sponsor":"Leigh Sowerby","startDate":"2023-09-25","conditions":["Loss of Smell","Olfactory Disorder"],"enrollment":120,"completionDate":"2024-11-21"},{"nctId":"NCT06013293","phase":"NA","title":"Evaluation of Postoperative Pain With Resin Based Sealer vs Zinc Oxide Eugenol Based Sealer After Single Visit Endodontic","status":"UNKNOWN","sponsor":"Pakistan Institute of Medical Sciences","startDate":"2022-10-01","conditions":["Post Operative Pain"],"enrollment":100,"completionDate":"2023-09-01"},{"nctId":"NCT05981352","phase":"NA","title":"Evaluation of Different Materials in Pulpotomy of Primary Molars","status":"UNKNOWN","sponsor":"Ain Shams University","startDate":"2023-10","conditions":["Pulp Disease, Dental"],"enrollment":36,"completionDate":"2024-10-01"},{"nctId":"NCT05908318","phase":"NA","title":"Effect of Preoperative Olfactory Training on Postoperative Delirium in the Elderly Undergoing Orthopedic Surgeries","status":"UNKNOWN","sponsor":"Sun Yat-Sen Memorial Hospital of Sun Yat-Sen University","startDate":"2023-07","conditions":["Preoperative Olfactory Training","Postoperative Delirium"],"enrollment":450,"completionDate":"2026-01"},{"nctId":"NCT04587089","phase":"PHASE1,PHASE2","title":"Efficacy of Guedes-Pinto Paste and CTZ Paste in the Non-instrumental Endodontic Treatment of Primary Teeth","status":"UNKNOWN","sponsor":"University of Nove de Julho","startDate":"2023-08-20","conditions":["Necrotic Pulp"],"enrollment":120,"completionDate":"2024-06-20"},{"nctId":"NCT05862441","phase":"PHASE2,PHASE3","title":"A Study to Assess the Efficacy of Omnivirol-Salicylic Acid Combination Therapy for Cutaneous Warts With Emphasis on Persistent Warts","status":"COMPLETED","sponsor":"Universiteit Antwerpen","startDate":"2018-01-01","conditions":["Cutaneous Warts"],"enrollment":260,"completionDate":"2019-12-31"},{"nctId":"NCT05850780","phase":"NA","title":"Clinical and Radiographic Evaluation of Laser Photobiomodulation Pulpotomy of Primary Molars in Children","status":"UNKNOWN","sponsor":"Aliaa Hamouda","startDate":"2022-12-01","conditions":["Pulpitis","Pulpotomy"],"enrollment":52,"completionDate":"2024-06"},{"nctId":"NCT05837416","phase":"PHASE4","title":"Effect of Oxidant Gel and Anti-oxidant Gel on Wound Healing After Gingival Depigmentation","status":"UNKNOWN","sponsor":"Cairo University","startDate":"2023-02-28","conditions":["Gingival Pigmentation"],"enrollment":30,"completionDate":"2024-05"},{"nctId":"NCT05816772","phase":"EARLY_PHASE1","title":"Comparison of Post-Operative Pain After Use of Calcium Hydroxide and Bio Ceramic Sealer for Root Canal Treatment.","status":"COMPLETED","sponsor":"Dow University of Health Sciences","startDate":"2022-10-25","conditions":["Postoperative Pain"],"enrollment":80,"completionDate":"2023-04-03"},{"nctId":"NCT05814003","phase":"NA","title":"Clinical Effectiveness of Polymethoxy Flavones Solid Dispersion as a Dressing Material for Palatal Grafts Donor Sites","status":"UNKNOWN","sponsor":"Assiut University","startDate":"2023-04-20","conditions":["Soft Tissue Infections","Gingival Recession"],"enrollment":30,"completionDate":"2023-05-20"},{"nctId":"NCT05792748","phase":"NA","title":"Comparison of Zinc Oxide Eugenol to Ferric Sulphate Pulpotomy in Primary Teeth","status":"COMPLETED","sponsor":"King Abdullah University Hospital","startDate":"2013-01-02","conditions":["Pulpotomy"],"enrollment":65,"completionDate":"2014-04-01"},{"nctId":"NCT05779800","phase":"NA","title":"The Use of Flowable Resin Composite Stent in Reduction of Donor Site Morbidity After Free Gingival Graft Harvesting","status":"UNKNOWN","sponsor":"Cairo University","startDate":"2023-02-15","conditions":["Free Gingival Graft"],"enrollment":34,"completionDate":"2023-12-05"},{"nctId":"NCT04102293","phase":"NA","title":"Time Efficiency and Obturation Quality of Rotary Versus Manual in Primary Teeth","status":"COMPLETED","sponsor":"Reem Mahmoud Abdelkader Awad","startDate":"2019-09-01","conditions":["Endodontic Disease"],"enrollment":41,"completionDate":"2022-01-01"},{"nctId":"NCT03687047","phase":"NA","title":"Impact of the Use of New Complete Denture on the Oral Health Related to Quality of Life (OHRQoL)","status":"COMPLETED","sponsor":"Universidade Federal Fluminense","startDate":"2017-03-25","conditions":["Edentulous Jaw","Quality of Life"],"enrollment":122,"completionDate":"2018-12-01"},{"nctId":"NCT05615272","phase":"NA","title":"Treatment of Alveolar Osteitis: Traditional or Regenerative?","status":"UNKNOWN","sponsor":"University of Dublin, Trinity College","startDate":"2022-10-01","conditions":["Alveolar Osteitis","Dry Socket","Pain","Healing","Tooth Extraction"],"enrollment":58,"completionDate":"2024-07"},{"nctId":"NCT04198376","phase":"NA","title":"The Laterally Closed Tunnel Versus Modified Coronally Advanced Tunnel for Mandibular Anterior Gingival Recession Defects","status":"COMPLETED","sponsor":"Krishnadevaraya College of Dental Sciences & Hospital","startDate":"2020-01-20","conditions":["Gingival Recession, Localized"],"enrollment":26,"completionDate":"2021-01-01"},{"nctId":"NCT05589025","phase":"NA","title":"Pulpotomy Versus Pulpectomy in Vital Primary Incisors","status":"COMPLETED","sponsor":"National Research Centre, Egypt","startDate":"2015-08-01","conditions":["Dental Caries","Pulp Disease, Dental"],"enrollment":39,"completionDate":"2016-12-15"},{"nctId":"NCT05583643","phase":"PHASE1","title":"Clinical & Biochemical Effect of Atorvastatin in Nano Particles Gel in Periodontitis Treatment","status":"COMPLETED","sponsor":"Misr University for Science and Technology","startDate":"2021-12-07","conditions":["Periodontitis"],"enrollment":24,"completionDate":"2022-06-30"},{"nctId":"NCT05475795","phase":"NA","title":"Postoperative Pain After Pulpectomy of Primary Molars Using Different Obturation Materials","status":"UNKNOWN","sponsor":"Minia University","startDate":"2022-06-09","conditions":["Post Operative Pain"],"enrollment":150,"completionDate":"2023-01-16"},{"nctId":"NCT05334745","phase":"PHASE1","title":"Clinical Comparison of Topical Application of Alvogyl Versus Hyaluronic-Acid Gel in Management of Pain And Palatal Wound Healing","status":"UNKNOWN","sponsor":"Cairo University","startDate":"2021-12-01","conditions":["Wound Healing"],"enrollment":16,"completionDate":"2023-01-01"},{"nctId":"NCT05240365","phase":"NA","title":"SDF Modified Hall Technique Vs. Conventional Pulpotomy for Management of Carious Primary Molars","status":"UNKNOWN","sponsor":"Sondos Naserallah","startDate":"2022-06","conditions":["Deep Carious Lesions"],"enrollment":42,"completionDate":"2023-06"},{"nctId":"NCT03650036","phase":"PHASE2","title":"Root Canal Treatment in Primary Molars With Necrotic Pulp Using Two Different Pulp Therapies","status":"COMPLETED","sponsor":"Federal University of Piaui","startDate":"2018-06-04","conditions":["Dental Pulp Necrosis"],"enrollment":86,"completionDate":"2022-03-04"},{"nctId":"NCT04935736","phase":"NA","title":"Postoperative Pain After Root Canal Obturation With Sealer Containing Prednisolone.","status":"COMPLETED","sponsor":"ACTEON Group","startDate":"2021-06-30","conditions":["Root Canal Obturation"],"enrollment":243,"completionDate":"2022-01-15"},{"nctId":"NCT05230797","phase":"EARLY_PHASE1","title":"Zincoxide-propolis vs Zincoxide-eugenol Pulpectomy","status":"UNKNOWN","sponsor":"Cairo University","startDate":"2022-04","conditions":["Pulp Necroses"],"enrollment":38,"completionDate":"2022-09"},{"nctId":"NCT05222243","phase":"PHASE4","title":"DPC in Primary Molars.","status":"COMPLETED","sponsor":"Mansoura University","startDate":"2019-01-01","conditions":["Direct Pulp Capping in Primary Teeth"],"enrollment":60,"completionDate":"2020-12-01"},{"nctId":"NCT04190914","phase":"NA","title":"Different Treatment Modality in Necrotic Primary Molars","status":"COMPLETED","sponsor":"dina darwish","startDate":"2020-02-07","conditions":["Primary Teeth","Dental Pulp Regeneration"],"enrollment":54,"completionDate":"2021-09-20"},{"nctId":"NCT05037110","phase":"NA","title":"Physical Activity and Smell Trainings to Help Individuals With Coronavirus Disease (COVID-19) Recover From Persistent Smell and Taste Impairments - A Pilot Study","status":"UNKNOWN","sponsor":"Université de Montréal","startDate":"2021-10-25","conditions":["Covid19"],"enrollment":75,"completionDate":"2023-06"},{"nctId":"NCT04779476","phase":"","title":"Effectiveness of Alveogyl and Cutanplast Dressing on Postoperative Pain Following Tooth Extraction: A Clinical Trial","status":"UNKNOWN","sponsor":"Riyadh Elm University","startDate":"2021-03-04","conditions":["Facial Pain","Pain, Postoperative","Pain, Orofacial"],"enrollment":50,"completionDate":"2021-12"},{"nctId":"NCT03885271","phase":"NA","title":"Outcomes of the Hall Technique and Conventional Pulp Therapy for the Management of Caries in Primary Molars","status":"COMPLETED","sponsor":"Cairo University","startDate":"2020-05-01","conditions":["Deep Caries","Pulpitis - Reversible"],"enrollment":56,"completionDate":"2021-08-01"},{"nctId":"NCT04115358","phase":"NA","title":"Evaluation of Hyaluronic Acid Pulpotomies in Primary Molars","status":"COMPLETED","sponsor":"Marmara University","startDate":"2019-05-01","conditions":["Pulpitis"],"enrollment":47,"completionDate":"2020-10-01"},{"nctId":"NCT04922372","phase":"PHASE4","title":"Surface Texture and Clinical Performance of Milled BioHPP Polyetheretherketone (PEEK) Single Posterior Crowns Veneered With Two Different Techniques","status":"UNKNOWN","sponsor":"Cairo University","startDate":"2021-07-22","conditions":["Surface Roughness"],"enrollment":26,"completionDate":"2022-12-22"},{"nctId":"NCT04207034","phase":"NA","title":"Effect of the Diode Laser on Bacteremia Associated With Periodontal Flap Surgery: A Clinico-Microbiological Study","status":"UNKNOWN","sponsor":"Krishnadevaraya College of Dental Sciences & Hospital","startDate":"2020-01-01","conditions":["Chronic Periodontitis"],"enrollment":10,"completionDate":"2021-01-10"},{"nctId":"NCT03472456","phase":"","title":"Endodontic Medications for Irreversible Pulpitis: Articaine or Eugenol?","status":"COMPLETED","sponsor":"University Hospital, Strasbourg, France","startDate":"2018-03-22","conditions":["Pulpitides","Endodontic Inflammation","Toothaches","Operative Dentistry"],"enrollment":100,"completionDate":"2019-10-24"},{"nctId":"NCT04495205","phase":"EARLY_PHASE1","title":"Effect of Non-eugenol Periodontal Pack With and Without PRF on Post-operative Pain and Wound Healing After Gingival Depigmentation","status":"UNKNOWN","sponsor":"Cairo University","startDate":"2020-01-01","conditions":["Gingival Pigmentation"],"enrollment":24,"completionDate":"2021-03"},{"nctId":"NCT04249206","phase":"PHASE4","title":"Outcome of Endodontic Treatment in Patient Treated With a Hydraulic Sealer","status":"UNKNOWN","sponsor":"Cittadella Universitaria","startDate":"2016-05-01","conditions":["Apical Periodontitis"],"enrollment":54,"completionDate":"2021-12"},{"nctId":"NCT03874949","phase":"NA","title":"Pain After Root Canal Obturation With Sealer Containing or Not 1% Enoxolone","status":"COMPLETED","sponsor":"ACTEON Group","startDate":"2019-04-02","conditions":["Root Canal Obturation"],"enrollment":95,"completionDate":"2019-08-20"},{"nctId":"NCT03917121","phase":"NA","title":"Pain Control of Needle-free Versus Needle Injected Local Anesthesia for Pulpotomy of Upper Primary Molars in Children","status":"UNKNOWN","sponsor":"Cairo University","startDate":"2019-08","conditions":["Anesthesia, Local"],"enrollment":46,"completionDate":"2020-05"},{"nctId":"NCT03589235","phase":"NA","title":"Platelet-Rich Fibrin Dressing in the Management of Free Gingival Graft","status":"COMPLETED","sponsor":"Damascus University","startDate":"2017-05-01","conditions":["Gingival Recession"],"enrollment":20,"completionDate":"2019-02-01"},{"nctId":"NCT03839719","phase":"NA","title":"OSE as a Pre-procedural Mouth Rinse: A Clinical and Microbiological Study.","status":"COMPLETED","sponsor":"Government College of Dentistry, Indore","startDate":"2019-01-09","conditions":["Gingivitis","Periodontitis","Aerosol Disease","Gingival Disease","Periodontal Diseases"],"enrollment":30,"completionDate":"2019-05-25"},{"nctId":"NCT03402321","phase":"PHASE4","title":"Alveogyl and Gelatin Sponge in the Management of Pain After Epithelialized Free Gingival Graft Harvesting","status":"UNKNOWN","sponsor":"Karim ehab gerges","startDate":"2019-04-01","conditions":["Pain, Procedural"],"enrollment":36,"completionDate":"2019-07-01"},{"nctId":"NCT03779698","phase":"PHASE4","title":"BiodentineTM Versus Formocresol Pulpotomy Technique in Primary Molars","status":"COMPLETED","sponsor":"King Abdulaziz University","startDate":"2014-05","conditions":["Dental Caries","Pulpotomy"],"enrollment":37,"completionDate":"2016-09"},{"nctId":"NCT03397875","phase":"NA","title":"Effect of Various Sealers on Healing of Teeth With Apical Periodontitis","status":"COMPLETED","sponsor":"Postgraduate Institute of Dental Sciences Rohtak","startDate":"2016-11","conditions":["Apical Periodontitis"],"enrollment":99,"completionDate":"2018-04"},{"nctId":"NCT02346227","phase":"PHASE3","title":"Impact of AV2 Antiviral Drug on the Treatment of HPV-associated Lesions of the Uterine Cervix","status":"COMPLETED","sponsor":"Jean-Pierre Van geertruyden","startDate":"2015-01","conditions":["Uterine Cervical Dysplasia","Papillomavirus Infections"],"enrollment":327,"completionDate":"2018-08"},{"nctId":"NCT02393326","phase":"NA","title":"Biodentine Partial Pulpotomy of Pulpally Exposed Primary Molars","status":"WITHDRAWN","sponsor":"Hadassah Medical Organization","startDate":"2018-01","conditions":["Pulpotomy","Tooth, Deciduous"],"enrollment":0,"completionDate":"2020-01"},{"nctId":"NCT03437655","phase":"NA","title":"Influence of the Composition of Temporary Restorative Material in Vital Teeth","status":"UNKNOWN","sponsor":"Federal University of Uberlandia","startDate":"2018-03-20","conditions":["MTA","Dental Restoration, Temporary"],"enrollment":25,"completionDate":"2018-10-30"},{"nctId":"NCT02201498","phase":"NA","title":"Randomized Clinical Trial for Primary Molar Pulpotomy, Biodentine Vs Formocresol-ZOE","status":"COMPLETED","sponsor":"Université de Montréal","startDate":"2014-09","conditions":["Deep Dental Caries"],"enrollment":180,"completionDate":"2016-06"},{"nctId":"NCT02630745","phase":"NA","title":"Immediate Verses Delayed Surgical Periodontal Therapy After Endodontic Treatment in Endo Perio Lesion With Communication","status":"COMPLETED","sponsor":"Postgraduate Institute of Dental Sciences Rohtak","startDate":"2015-06","conditions":["Attachment Loss","Tooth,Non Vital"],"enrollment":40,"completionDate":"2016-10"},{"nctId":"NCT03166748","phase":"NA","title":"Clinical and Radiographic Assessments of Potassium Nitrate in Polycarboxylate Versus Mineral Trioxide Aggregate as Pulpotomy Biomaterials in Immature Mandibular First Permanent Molars","status":"UNKNOWN","sponsor":"Cairo University","startDate":"2017-06","conditions":["Pulpotomy of Immature Lower First Molar(Apexegenesis)"],"enrollment":50,"completionDate":"2018-08"},{"nctId":"NCT01622153","phase":"NA","title":"Electrical and Formocresol Pulpotomy in Primary Molars","status":"TERMINATED","sponsor":"University Hospitals Cleveland Medical Center","startDate":"2011-06","conditions":["Reversible Pulpitis","Caries"],"enrollment":120,"completionDate":"2014-06"},{"nctId":"NCT01728532","phase":"NA","title":"Open, Multicentric Trial Evaluating the Efficacy and the Clinical Tolerance of PA0903 as Root Canal Sealer","status":"COMPLETED","sponsor":"Ascopharm Groupe Novasco","startDate":"2012-06","conditions":["Root Canal Obturation"],"enrollment":26,"completionDate":"2016-06"},{"nctId":"NCT02652403","phase":"PHASE2","title":"Simplified Versus Conventional Technique for Complete Denture Fabrication.","status":"COMPLETED","sponsor":"Universidade Federal do Rio Grande do Norte","startDate":"2015-03","conditions":["Edentulous"],"enrollment":42,"completionDate":"2015-12"}],"genericFilers":[],"latestUpdates":[],"manufacturing":[],"administration":{"route":"Topical, Dental, Oral","formulation":"Cream, Gel, Liquid, Ointment","formulations":[{"form":"CREAM","route":"TOPICAL","productName":"Anubis Barcelona"},{"form":"GEL","route":"DENTAL","productName":"AnaDent Childrens Kanka Gel"},{"form":"GEL","route":"TOPICAL","productName":"Nuby Teething Gel"},{"form":"LIQUID","route":"DENTAL","productName":"DenTek Eugenol"},{"form":"LIQUID","route":"DENTAL","productName":"Eugenol Toothache Medication"},{"form":"LIQUID","route":"DENTAL","productName":"Walgreens Natural Eugenol/Toothache Medicationwith cotton pellets and tweezers"},{"form":"LIQUID","route":"ORAL","productName":"Dairy Allergen Mix"},{"form":"LIQUID","route":"TOPICAL","productName":"Red Cross Toothache"},{"form":"OINTMENT","route":"TOPICAL","productName":"PainONil"},{"form":"OINTMENT","route":"TOPICAL","productName":"TotalArthritis"},{"form":"PASTE","route":"DENTAL","productName":"Dry Socket"},{"form":"SOLUTION/ DROPS","route":"DENTAL","productName":"Marshall Toothache Drops"}]},"crossReferences":{"NUI":"N0000147369","MMSL":"12028","NDDF":"001106","UNII":"3T8H1794QW","VUID":"4019118","CHEBI":"CHEBI:4917","VANDF":"4019118","RXNORM":"4186","UMLSCUI":"C0015153","ChEMBL_ID":"CHEMBL42710","KEGG_DRUG":"D04117","DRUGBANK_ID":"DB09086","PDB_CHEM_ID":" EOL","PUBCHEM_CID":"3314","SNOMEDCT_US":"255924000","IUPHAR_LIGAND_ID":"2425","MESH_DESCRIPTOR_UI":"D005054"},"formularyStatus":[],"_enricherVersion":"v2","developmentCodes":[],"ownershipHistory":[{"period":"present","companyName":"HITEC-Institute of Medical Sciences","relationship":"Current Owner"}],"publicationCount":6568,"therapeuticAreas":["Cardiovascular"],"biosimilarFilings":[],"recentPublications":[],"companionDiagnostics":[],"genericManufacturerList":[],"status":"active","companyName":"HITEC-Institute of Medical Sciences","companyId":"hitec-institute-of-medical-sciences","modality":"Small molecule","firstApprovalDate":"","enrichmentLevel":3,"visitCount":1,"regulatoryByCountry":[{"country_code":"US","regulator":"FDA","status":"approved","approval_date":null,"mah":"","brand_name_local":null,"application_number":""},{"country_code":"BR","regulator":"ANVISA","status":"likely_approved","approval_date":null,"mah":null,"brand_name_local":null,"application_number":null},{"country_code":"MX","regulator":"COFEPRIS","status":"likely_approved","approval_date":null,"mah":null,"brand_name_local":null,"application_number":null},{"country_code":"AR","regulator":"ANMAT","status":"likely_approved","approval_date":null,"mah":null,"brand_name_local":null,"application_number":null},{"country_code":"TR","regulator":"TITCK","status":"likely_approved","approval_date":null,"mah":null,"brand_name_local":null,"application_number":null},{"country_code":"IN","regulator":"CDSCO","status":"likely_approved","approval_date":null,"mah":null,"brand_name_local":null,"application_number":null},{"country_code":"TH","regulator":"FDA-TH","status":"likely_approved","approval_date":null,"mah":null,"brand_name_local":null,"application_number":null},{"country_code":"MY","regulator":"NPRA","status":"likely_approved","approval_date":null,"mah":null,"brand_name_local":null,"application_number":null},{"country_code":"PH","regulator":"FDA-PH","status":"likely_approved","approval_date":null,"mah":null,"brand_name_local":null,"application_number":null},{"country_code":"CO","regulator":"INVIMA","status":"likely_approved","approval_date":null,"mah":null,"brand_name_local":null,"application_number":null},{"country_code":"ZA","regulator":"SAHPRA","status":"likely_approved","approval_date":null,"mah":null,"brand_name_local":null,"application_number":null},{"country_code":"TW","regulator":"TFDA","status":"likely_approved","approval_date":null,"mah":null,"brand_name_local":null,"application_number":null},{"country_code":"HK","regulator":"DH","status":"likely_approved","approval_date":null,"mah":null,"brand_name_local":null,"application_number":null},{"country_code":"CA","regulator":"Health Canada","status":"likely_approved","approval_date":null,"mah":null,"brand_name_local":null,"application_number":null},{"country_code":"IL","regulator":"MOH","status":"likely_approved","approval_date":null,"mah":null,"brand_name_local":null,"application_number":null},{"country_code":"SG","regulator":"HSA","status":"likely_approved","approval_date":null,"mah":null,"brand_name_local":null,"application_number":null},{"country_code":"AE","regulator":"MOH","status":"likely_approved","approval_date":null,"mah":null,"brand_name_local":null,"application_number":null},{"country_code":"KR","regulator":"MFDS","status":"likely_approved","approval_date":null,"mah":null,"brand_name_local":null,"application_number":null},{"country_code":"AU","regulator":"TGA","status":"likely_approved","approval_date":null,"mah":null,"brand_name_local":null,"application_number":null},{"country_code":"GB","regulator":"MHRA","status":"likely_approved","approval_date":null,"mah":null,"brand_name_local":null,"application_number":null}],"trialStats":{"total":1,"withResults":0},"verificationStatus":"partial","dataCompleteness":{"mechanism":true,"indications":false,"safety":false,"trials":true,"score":2}}