{"id":"euflavine","rwe":[{"pmid":"24683020","year":"2014","title":"Vasectomy occlusion techniques for male sterilization.","finding":"","journal":"The Cochrane database of systematic reviews","studyType":"Clinical Study"},{"pmid":"17443535","year":"2007","title":"Vasectomy occlusion techniques for male sterilization.","finding":"","journal":"The Cochrane database of systematic reviews","studyType":"Clinical Study"},{"pmid":"15496598","year":"2004","title":"Vasectomy techniques for male sterilization: systematic Cochrane review of randomized controlled trials and controlled clinical trials.","finding":"","journal":"Human reproduction (Oxford, England)","studyType":"Clinical Study"},{"pmid":"15266511","year":"2004","title":"Vasectomy occlusion techniques for male sterilization.","finding":"","journal":"The Cochrane database of systematic reviews","studyType":"Clinical Study"},{"pmid":"8130775","year":"1993","title":"Photodynamic DNA strand breaking activities of acridine compounds.","finding":"","journal":"Biological & pharmaceutical bulletin","studyType":"Clinical Study"}],"tags":[{"label":"euflavine","category":"class"},{"label":"Small Molecule","category":"modality"},{"label":"Hypoxia-inducible factor 1-alpha","category":"target"},{"label":"HIF1A","category":"gene"},{"label":"D08AA03","category":"atc"},{"label":"Active","category":"status"},{"label":"Anti-Infective Agents","category":"pharmacology"},{"label":"Anti-Infective Agents, Local","category":"pharmacology"},{"label":"Coloring Agents","category":"pharmacology"},{"label":"Fluorescent Dyes","category":"pharmacology"},{"label":"Indicators and Reagents","category":"pharmacology"},{"label":"Intercalating Agents","category":"pharmacology"},{"label":"Luminescent Agents","category":"pharmacology"}],"phase":"unknown","safety":{},"trials":[],"aliases":[],"patents":[],"pricing":[],"allNames":"acriflavine","offLabel":[],"synonyms":["acriflavinium chloride","acriflavine chloride","acriflavine","euflavine"],"timeline":[],"approvals":[],"brandName":"Acriflavine","ecosystem":[],"mechanism":{"target":"Hypoxia-inducible factor 1-alpha, ORF 73","targets":[{"gene":"HIF1A","source":"DrugCentral","target":"Hypoxia-inducible factor 1-alpha","protein":"Hypoxia-inducible factor 1-alpha"}],"modality":"Small Molecule","drugClass":"euflavine","explanation":"Think of hypoxia-inducible factor 1-alpha like a switch that helps cells survive in low-oxygen environments. Acriflavine turns off this switch, which can help prevent the growth of certain types of cancer cells that thrive in low-oxygen conditions.","oneSentence":"Acriflavine works by binding to and inhibiting hypoxia-inducible factor 1-alpha, a protein that helps cells adapt to low oxygen levels.","technicalDetail":"Acriflavine exerts its effects by interacting with the hypoxia-inducible factor 1-alpha protein, thereby disrupting its ability to regulate gene expression in response to hypoxic conditions."},"_wikipedia":{"url":"https://en.wikipedia.org/wiki/Euflavine","title":"Euflavine","extract":"Euflavine is an antiseptic and disinfectant."},"commercial":{},"references":[{"id":1,"url":"https://drugcentral.org/drugcard/4317","fields":["approvals","synonyms","ATC","PK","indications","contraindications","DDIs","targets","patents","FAERS"],"source":"DrugCentral"},{"id":2,"url":"https://clinicaltrials.gov/search?intr=euflavine","fields":["trials"],"source":"ClinicalTrials.gov"},{"id":3,"url":"https://pubmed.ncbi.nlm.nih.gov/?term=euflavine","fields":["publications"],"source":"PubMed/NCBI"},{"id":4,"url":"https://en.wikipedia.org/wiki/Euflavine","fields":["history","overview"],"source":"Wikipedia"}],"_enrichedAt":"2026-03-30T11:11:09.624331","biosimilars":[],"competitors":[{"drugName":"deferoxamine","drugSlug":"deferoxamine","fdaApproval":"1968-04-01","genericCount":5,"patentStatus":"Off-patent — generic available","relationship":"same-target"},{"drugName":"topotecan","drugSlug":"topotecan","fdaApproval":"1996-05-28","genericCount":11,"patentStatus":"Off-patent — generic available","relationship":"same-target"}],"dataSources":[{"url":"https://drugcentral.org","name":"DrugCentral","fields":["indications","contraindications","safety","target","drugInteractions"],"retrievedDate":"2026-04-07"}],"genericName":"euflavine","indications":{"approved":[],"offLabel":[],"pipeline":[]},"drugCategory":"active","labelChanges":[],"relatedDrugs":[{"drugId":"deferoxamine","brandName":"deferoxamine","genericName":"deferoxamine","approvalYear":"1968","relationship":"same-target"},{"drugId":"topotecan","brandName":"topotecan","genericName":"topotecan","approvalYear":"1996","relationship":"same-target"}],"trialDetails":[{"nctId":"NCT03379389","phase":"PHASE4","title":"Clinical Assessment of Urinary Antiseptics Methenamine and Methylthioninium in Recurrent Cystitis","status":"COMPLETED","sponsor":"Fundação Educacional Serra dos Órgãos","startDate":"2018-03-31","conditions":["Urinary Tract Infections"],"enrollment":284,"completionDate":"2021-06-01"}],"genericFilers":[],"latestUpdates":[],"manufacturing":[],"administration":{},"crossReferences":{"NUI":"N0000148332","MMSL":"NOCODE","NDDF":"002613","UNII":"1T3A50395T","VUID":"4020812","CHEBI":"CHEBI:74729","VANDF":"4020580","RXNORM":"1664337","UMLSCUI":"C0001187","ChEMBL_ID":"CHEMBL354349","DRUGBANK_ID":"DB13326","PUBCHEM_CID":"443101","SNOMEDCT_US":"412535007","SECONDARY_CAS_RN":"65589-70-0","MESH_DESCRIPTOR_UI":"D000167","MESH_SUPPLEMENTAL_RECORD_UI":"C000718540"},"formularyStatus":[],"_enricherVersion":"v2","developmentCodes":[],"ownershipHistory":[],"publicationCount":25,"therapeuticAreas":["Oncology"],"atcClassification":{"source":"DrugCentral","atcCode":"D08AA03","allCodes":["D08AA03","R02AA13"]},"biosimilarFilings":[],"recentPublications":[{"date":"2014 Mar 30","pmid":"24683020","title":"Vasectomy occlusion techniques for male sterilization.","journal":"The Cochrane database of systematic reviews"},{"date":"2007 Apr 18","pmid":"17443535","title":"Vasectomy occlusion techniques for male sterilization.","journal":"The Cochrane database of systematic reviews"},{"date":"2004 Nov","pmid":"15496598","title":"Vasectomy techniques for male sterilization: systematic Cochrane review of randomized controlled trials and controlled clinical trials.","journal":"Human reproduction (Oxford, England)"},{"date":"2004","pmid":"15266511","title":"Vasectomy occlusion techniques for male sterilization.","journal":"The Cochrane database of systematic reviews"},{"date":"1993 Dec","pmid":"8130775","title":"Photodynamic DNA strand breaking activities of acridine compounds.","journal":"Biological & pharmaceutical bulletin"}],"companionDiagnostics":[],"genericManufacturerList":[],"status":"active","companyName":"","companyId":"unknown","modality":"Small Molecule","firstApprovalDate":"","aiSummary":"Acriflavine is an antiseptic and disinfectant, as classified by Wikipedia. It is being studied in combination with other treatments for urinary tract infections, specifically in the clinical trial \"Clinical Assessment of Urinary Antiseptics Methenamine and Methylthioninium in Recurrent Cystitis\" (NCT03379389).","enrichmentLevel":3,"visitCount":0,"trialStats":{"total":0,"withResults":0},"verificationStatus":"partial","dataCompleteness":{"mechanism":true,"indications":false,"safety":false,"trials":true,"score":2}}