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It is a second-generation retinoid. It was subsequently removed from the Canadian market in 1996 and the United States market in 1998 due to the high risk of birth defects. It remains on the market in Japan as Tigason.","wiki_history":"==History==\nEtretinate received FDA approval in 1986 for the treatment of severe psoriasis. However, it was voluntarily withdrawn from the Canadian market in 1996 and the United States market in 1998 due to its prolonged elimination half-life and significant teratogenic potential. Because the drug accumulates in adipose tissue, it can pose a high risk of birth defects for several years following the cessation of therapy. 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