{"id":"etoxadrol","rwe":[{"pmid":"29377520","year":"2018","title":"Comparative Pharmacological Study of Common NMDA Receptor Open Channel Blockers Regarding Their Affinity and Functional Activity toward GluN2A and GluN2B NMDA Receptors.","finding":"","journal":"ChemMedChem","studyType":"Clinical Study"},{"pmid":"21444132","year":"2011","title":"Synthesis of 4-(aminoalkyl) substituted 1,3-dioxanes as potent NMDA and σ receptor antagonists.","finding":"","journal":"European journal of medicinal chemistry","studyType":"Clinical Study"},{"pmid":"16719812","year":"2006","title":"Relationships between the structure of dexoxadrol and etoxadrol analogues and their NMDA receptor affinity.","finding":"","journal":"Current topics in medicinal chemistry","studyType":"Clinical Study"},{"pmid":"16169732","year":"2005","title":"Structure-affinity relationship studies of non-competitive NMDA receptor antagonists derived from dexoxadrol and etoxadrol.","finding":"","journal":"Bioorganic & medicinal chemistry","studyType":"Clinical Study"},{"pmid":"8355251","year":"1993","title":"Synthesis and binding properties of MK-801 isothiocyanates; (+)-3-isothiocyanato-5-methyl-10,11-dihydro-5H-dibenzo[a,d]cyclohepten- 5,10-imine hydrochloride: a new, potent and selective electrophilic affinity ligand for the NMDA receptor-coupled phencyclidine binding site.","finding":"","journal":"Journal of medicinal chemistry","studyType":"Clinical Study"}],"tags":[{"label":"Small Molecule","category":"modality"},{"label":"Active","category":"status"}],"phase":"phase_2","safety":{},"trials":[],"aliases":[],"patents":[],"pricing":[],"allNames":["etoxadrol","etoxadrol hydrochloride","etoxadrol HCl"],"offLabel":[],"synonyms":["etoxadrol","etoxadrol hydrochloride","etoxadrol HCl"],"timeline":[],"approvals":[],"ecosystem":[],"mechanism":{"target":"Glutamate NMDA receptor","modality":"Small Molecule","explanation":"Imagine ETOXADROL as a key that fits into a lock on a specific protein in the body. When it binds to this protein, it can either block or enhance the protein's activity, leading to changes in the body's chemistry that can help treat a particular disease or condition. This is a simplified explanation of how small molecule drugs like ETOXADROL work.","oneSentence":"ETOXADROL works by binding to specific biological molecules to produce a therapeutic effect.","technicalDetail":"ETOXADROL's mechanism of action is likely to involve reversible binding to a specific target protein, leading to allosteric modulation of the protein's activity and subsequent downstream effects on cellular signaling pathways."},"commercial":{},"references":[{"id":1,"url":"https://drugcentral.org/drugcard/3215","fields":["approvals","synonyms","ATC","PK","indications","contraindications","DDIs","targets","patents","FAERS"],"source":"DrugCentral"},{"id":2,"url":"https://pubmed.ncbi.nlm.nih.gov/?term=ETOXADROL","fields":["publications"],"source":"PubMed/NCBI"}],"_enrichedAt":"2026-03-30T11:10:34.354960","biosimilars":[],"competitors":[{"drugName":"aspartic acid","drugSlug":"aspartic-acid","fdaApproval":"","relationship":"same-target"},{"drugName":"chlorpromazine","drugSlug":"chlorpromazine","fdaApproval":"1957-09-18","patentStatus":"Unknown","relationship":"same-target"},{"drugName":"cycloserine","drugSlug":"cycloserine","fdaApproval":"1964-06-29","genericCount":1,"patentStatus":"Off-patent — generic available","relationship":"same-target"},{"drugName":"dextromethorphan","drugSlug":"dextromethorphan","fdaApproval":"1957-12-03","genericCount":2,"patentStatus":"Off-patent — generic available","relationship":"same-target"},{"drugName":"dextrothyroxine","drugSlug":"dextrothyroxine","fdaApproval":"1967-04-14","patentStatus":"Unknown","relationship":"same-target"},{"drugName":"esketamine","drugSlug":"esketamine","fdaApproval":"2019-05-03","patentExpiry":"Sep 10, 2035","patentStatus":"Patent protected","relationship":"same-target"},{"drugName":"glycine","drugSlug":"glycine","fdaApproval":"1976-05-25","patentStatus":"Unknown","relationship":"same-target"},{"drugName":"imipramine","drugSlug":"imipramine","fdaApproval":"1959-04-16","genericCount":3,"patentStatus":"Off-patent — generic available","relationship":"same-target"},{"drugName":"ketamine","drugSlug":"ketamine","fdaApproval":"1970-02-19","genericCount":7,"patentStatus":"Off-patent — generic available","relationship":"same-target"},{"drugName":"levomilnacipran","drugSlug":"levomilnacipran","fdaApproval":"2013-07-25","patentExpiry":"May 23, 2032","patentStatus":"Patent protected","relationship":"same-target"}],"dataSources":[{"url":"https://drugcentral.org","name":"DrugCentral","fields":["indications","contraindications","safety","target","drugInteractions"],"retrievedDate":"2026-04-07"}],"genericName":"etoxadrol","indications":{"approved":[],"offLabel":[],"pipeline":[]},"drugCategory":"active","labelChanges":[],"relatedDrugs":[{"drugId":"aspartic-acid","brandName":"aspartic acid","genericName":"aspartic acid","approvalYear":"","relationship":"same-target"},{"drugId":"chlorpromazine","brandName":"chlorpromazine","genericName":"chlorpromazine","approvalYear":"1957","relationship":"same-target"},{"drugId":"cycloserine","brandName":"cycloserine","genericName":"cycloserine","approvalYear":"1964","relationship":"same-target"},{"drugId":"dextromethorphan","brandName":"dextromethorphan","genericName":"dextromethorphan","approvalYear":"1957","relationship":"same-target"},{"drugId":"dextrothyroxine","brandName":"dextrothyroxine","genericName":"dextrothyroxine","approvalYear":"1967","relationship":"same-target"},{"drugId":"esketamine","brandName":"esketamine","genericName":"esketamine","approvalYear":"2019","relationship":"same-target"},{"drugId":"glycine","brandName":"glycine","genericName":"glycine","approvalYear":"1976","relationship":"same-target"},{"drugId":"imipramine","brandName":"imipramine","genericName":"imipramine","approvalYear":"1959","relationship":"same-target"},{"drugId":"ketamine","brandName":"ketamine","genericName":"ketamine","approvalYear":"1970","relationship":"same-target"},{"drugId":"levomilnacipran","brandName":"levomilnacipran","genericName":"levomilnacipran","approvalYear":"2013","relationship":"same-target"}],"trialDetails":[],"genericFilers":[],"latestUpdates":[],"manufacturing":[],"administration":{},"crossReferences":{"UNII":"SIQ2UWR01K","CHEBI":"CHEBI:135073","INN_ID":"2796","UMLSCUI":"C0015135","ChEMBL_ID":"CHEMBL305904","KEGG_DRUG":"D04110","PUBCHEM_CID":"14208380","SECONDARY_CAS_RN":"23239-37-4","MESH_SUPPLEMENTAL_RECORD_UI":"C084821"},"formularyStatus":[],"_enricherVersion":"v2","developmentCodes":[],"ownershipHistory":[],"publicationCount":38,"therapeuticAreas":["Other"],"biosimilarFilings":[],"recentPublications":[{"date":"2018 Mar 6","pmid":"29377520","title":"Comparative Pharmacological Study of Common NMDA Receptor Open Channel Blockers Regarding Their Affinity and Functional Activity toward GluN2A and GluN2B NMDA Receptors.","journal":"ChemMedChem"},{"date":"2011 Jun","pmid":"21444132","title":"Synthesis of 4-(aminoalkyl) substituted 1,3-dioxanes as potent NMDA and σ receptor antagonists.","journal":"European journal of medicinal chemistry"},{"date":"2006","pmid":"16719812","title":"Relationships between the structure of dexoxadrol and etoxadrol analogues and their NMDA receptor affinity.","journal":"Current topics in medicinal chemistry"},{"date":"2005 Dec 15","pmid":"16169732","title":"Structure-affinity relationship studies of non-competitive NMDA receptor antagonists derived from dexoxadrol and etoxadrol.","journal":"Bioorganic & medicinal chemistry"},{"date":"1993 Aug 20","pmid":"8355251","title":"Synthesis and binding properties of MK-801 isothiocyanates; (+)-3-isothiocyanato-5-methyl-10,11-dihydro-5H-dibenzo[a,d]cyclohepten- 5,10-imine hydrochloride: a new, potent and selective electrophilic affinity ligand for the NMDA receptor-coupled phencyclidine binding site.","journal":"Journal of medicinal chemistry"}],"companionDiagnostics":[],"genericManufacturerList":[],"status":"active","brandName":"ETOXADROL","companyName":"","companyId":"","modality":"Small molecule","firstApprovalDate":"","aiSummary":"ETOXADROL is a small molecule drug with unknown target and drug class. Its commercial status is unclear, and it has not been approved by the FDA for any indications. As a small molecule, it is likely to work by interacting with specific biological molecules to produce a therapeutic effect. However, without more information, it is difficult to provide a comprehensive summary of its mechanism of action and safety considerations. Further research is needed to fully understand ETOXADROL's properties and potential uses.","enrichmentLevel":3,"visitCount":0,"trialStats":{"total":0,"withResults":0},"verificationStatus":"partial","dataCompleteness":{"mechanism":true,"indications":false,"safety":false,"trials":false,"score":1}}