{"id":"etoposide-et","safety":{"commonSideEffects":[{"rate":"40-90","effect":"Myelosuppression (neutropenia, thrombocytopenia, anemia)"},{"rate":"30-50","effect":"Nausea and vomiting"},{"rate":"20-40","effect":"Alopecia"},{"rate":"10-30","effect":"Mucositis"},{"rate":"10-20","effect":"Diarrhea"},{"rate":"1-5","effect":"Secondary acute leukemia"},{"rate":"1-3","effect":"Hypersensitivity reactions"}]},"_chembl":null,"_dailymed":{"setId":"acc1e443-ef7b-486f-a638-710a20e81059","title":"AVOPEF (ETOPOSIDE) INJECTION [AVYXA PHARMA, LLC]"},"mechanism":{"_ai_source":"claude-haiku-4.5","explanation":"Etoposide binds to the topoisomerase II–DNA complex and stabilizes the cleavage complex, preventing the religation of DNA strands. This results in accumulation of DNA double-strand breaks, particularly in S and G2 phases of the cell cycle, triggering apoptosis in cancer cells. It is a semisynthetic derivative of podophyllotoxin.","oneSentence":"Etoposide is a topoisomerase II inhibitor that prevents DNA religation, leading to DNA breaks and cell death in rapidly dividing cells.","_ai_confidence":"high"},"_scrapedAt":"2026-03-28T01:11:48.115Z","_scrapedBy":"cloudflare-swarm","_wikipedia":null,"indications":{"approved":[{"name":"Small cell lung cancer"},{"name":"Testicular cancer"},{"name":"Lymphomas"},{"name":"Leukemias"},{"name":"Ovarian cancer"}]},"trialDetails":[{"nctId":"NCT07291102","phase":"PHASE3","title":"Comparison of Neurocognitive Outcome in Two Standard Regimen for Treatment of Low-risk Medulloblastoma","status":"NOT_YET_RECRUITING","sponsor":"Nationwide Children's Hospital","startDate":"2026-07-01","conditions":"Medulloblastoma","enrollment":96},{"nctId":"NCT00470223","phase":"PHASE3","title":"Combined Chemotherapy With or Without Zoledronic Acid for Patients With Osteosarcoma","status":"ACTIVE_NOT_RECRUITING","sponsor":"UNICANCER","startDate":"2007-03","conditions":"Sarcoma","enrollment":318},{"nctId":"NCT01435018","phase":"PHASE3","title":"Three Chemo Regimens as an Adjunct to ART for Treatment of Advanced AIDS-KS","status":"COMPLETED","sponsor":"Advancing Clinical Therapeutics Globally for HIV/AIDS and Other Infections","startDate":"2013-10-01","conditions":"HIV-1 Infection","enrollment":334},{"nctId":"NCT01352117","phase":"PHASE3","title":"Antiretroviral Therapy (ART) Alone or With Delayed Chemo Versus ART With Immediate Chemo for Limited AIDS-related Kaposi's Sarcoma","status":"COMPLETED","sponsor":"Advancing Clinical Therapeutics Globally for HIV/AIDS and Other Infections","startDate":"2011-11-18","conditions":"HIV-1 Infection, Kaposi's Sarcoma","enrollment":192},{"nctId":"NCT03018626","phase":"PHASE3","title":"R-ACVBP and DA-EPOCH-R in Patients With Non-GCB DLBCL","status":"UNKNOWN","sponsor":"Nanfang Hospital, Southern Medical University","startDate":"2017-07-27","conditions":"Lymphoma, Large B-Cell, Diffuse","enrollment":402},{"nctId":"NCT01304043","phase":"","title":"French Observatory of Rare Malignant Tumors of the Ovary","status":"COMPLETED","sponsor":"ARCAGY/ GINECO GROUP","startDate":"2002-01","conditions":"Ovarian Tumors","enrollment":204}],"_emaApprovals":[],"_faersSignals":[],"_approvalHistory":[],"publicationCount":260,"rwe":[],"genericFilers":[],"relatedDrugs":[],"labelChanges":[],"biosimilarFilings":[],"pricing":[],"formularyStatus":[],"manufacturing":[],"companionDiagnostics":[],"competitors":[],"timeline":[],"patents":[],"ownershipHistory":[],"trials":[],"biosimilars":[],"latestUpdates":[],"references":[],"tags":[],"ecosystem":[],"genericManufacturerList":[],"offLabel":[],"developmentCodes":[],"aliases":[],"phase":"marketed","status":"active","brandName":"Etoposide (ET)","genericName":"Etoposide (ET)","companyName":"Advancing Clinical Therapeutics Globally for HIV/AIDS and Other Infections","companyId":"advancing-clinical-therapeutics-globally-for-hiv-aids-and-other-infections","modality":"Small molecule","firstApprovalDate":"","aiSummary":"Etoposide is a topoisomerase II inhibitor that prevents DNA religation, leading to DNA breaks and cell death in rapidly dividing cells. Used for Small cell lung cancer, Testicular cancer, Lymphomas.","enrichmentLevel":3,"visitCount":1,"trialStats":{"total":0,"withResults":0},"verificationStatus":"verified","dataCompleteness":{"mechanism":true,"indications":true,"safety":true,"trials":true,"score":4}}