{"id":"etoperidone","rwe":[],"tags":[{"label":"Selective Serotonin Reuptake Inhibitors","category":"class"},{"label":"Small Molecule","category":"modality"},{"label":"5-hydroxytryptamine receptor 1A","category":"target"},{"label":"HTR1A","category":"gene"},{"label":"SLC6A4","category":"gene"},{"label":"DRD2","category":"gene"},{"label":"N06AB09","category":"atc"},{"label":"Active","category":"status"}],"phase":"phase_2","safety":{},"trials":[],"aliases":[],"patents":[],"pricing":[],"_fixedAt":"2026-03-30T16:58:17.439189","allNames":"clopradone","offLabel":[],"synonyms":["clopradone","triazolinone","etoperidone","etoperidone hydrochloride","etoperidone HCl"],"timeline":[],"approvals":[],"brandName":"Clopradone","ecosystem":[],"mechanism":{"target":"5-hydroxytryptamine receptor 1A, D(2) dopamine receptor, Histamine H1 receptor","targets":[{"gene":"SLC6A4","source":"DrugCentral","target":"Sodium-dependent serotonin transporter","protein":"Sodium-dependent serotonin transporter","isPrimary":true,"activityType":"Ki","activityValue":6.051},{"gene":"HTR1A","source":"DrugCentral","target":"5-hydroxytryptamine receptor 1A","protein":"5-hydroxytryptamine receptor 1A"},{"gene":"DRD2","source":"DrugCentral","target":"D(2) dopamine receptor","protein":"D(2) dopamine receptor"},{"gene":"HRH1","source":"DrugCentral","target":"Histamine H1 receptor","protein":"Histamine H1 receptor"}],"modality":"Small Molecule","drugClass":"Selective Serotonin Reuptake Inhibitors","explanation":"Imagine your brain is a network of messengers, and serotonin is one of the key messengers that helps you feel happy and calm. When you take Clopradone, it helps prevent these messengers from being taken back in, so there are more of them available to help you feel better.","oneSentence":"Clopradone works by blocking the reabsorption of serotonin in the brain, allowing more of this neurotransmitter to be available for communication between nerve cells.","technicalDetail":"Clopradone acts as a selective serotonin reuptake inhibitor (SSRI) by competitively binding to the serotonin transporter (SERT), thereby preventing the reuptake of serotonin into the presynaptic neuron and increasing the concentration of serotonin in the synaptic cleft."},"commercial":{},"references":[{"id":1,"url":"https://drugcentral.org/drugcard/1111","fields":["approvals","synonyms","ATC","PK","indications","contraindications","DDIs","targets","patents","FAERS"],"source":"DrugCentral"},{"id":2,"url":"https://pubmed.ncbi.nlm.nih.gov/?term=ETOPERIDONE","fields":["publications"],"source":"PubMed/NCBI"}],"_enrichedAt":"2026-03-30T11:10:22.967569","biosimilars":[],"competitors":[{"drugName":"fluoxetine","drugSlug":"fluoxetine","fdaApproval":"1987-12-29","genericCount":49,"patentStatus":"Off-patent — generic available","relationship":"same-class"},{"drugName":"citalopram","drugSlug":"citalopram","fdaApproval":"1998-07-17","genericCount":26,"patentStatus":"Off-patent — generic available","relationship":"same-class"},{"drugName":"paroxetine","drugSlug":"paroxetine","fdaApproval":"1992-12-29","patentExpiry":"Aug 4, 2026","patentStatus":"Patent protected","relationship":"same-class"},{"drugName":"sertraline","drugSlug":"sertraline","fdaApproval":"1991-12-30","genericCount":31,"patentStatus":"Off-patent — generic available","relationship":"same-class"},{"drugName":"fluvoxamine","drugSlug":"fluvoxamine","fdaApproval":"1994-12-05","genericCount":17,"patentStatus":"Off-patent — generic available","relationship":"same-class"},{"drugName":"escitalopram","drugSlug":"escitalopram","fdaApproval":"2002-08-14","genericCount":21,"patentStatus":"Off-patent — generic available","relationship":"same-class"}],"dataSources":[{"url":"https://drugcentral.org","name":"DrugCentral","fields":["indications","contraindications","safety","target","drugInteractions"],"retrievedDate":"2026-04-07"}],"genericName":"etoperidone","indications":{"approved":[],"offLabel":[],"pipeline":[]},"_fixedFields":["primaryTarget"],"drugCategory":"active","labelChanges":[],"relatedDrugs":[{"drugId":"fluoxetine","brandName":"fluoxetine","genericName":"fluoxetine","approvalYear":"1987","relationship":"same-class"},{"drugId":"citalopram","brandName":"citalopram","genericName":"citalopram","approvalYear":"1998","relationship":"same-class"},{"drugId":"paroxetine","brandName":"paroxetine","genericName":"paroxetine","approvalYear":"1992","relationship":"same-class"},{"drugId":"sertraline","brandName":"sertraline","genericName":"sertraline","approvalYear":"1991","relationship":"same-class"},{"drugId":"fluvoxamine","brandName":"fluvoxamine","genericName":"fluvoxamine","approvalYear":"1994","relationship":"same-class"},{"drugId":"escitalopram","brandName":"escitalopram","genericName":"escitalopram","approvalYear":"2002","relationship":"same-class"}],"trialDetails":[],"genericFilers":[],"latestUpdates":[],"manufacturing":[],"administration":{},"crossReferences":{"UNII":"KAI6MVO39Z","CHEBI":"CHEBI:135589","INN_ID":"4023","UMLSCUI":"C0059873","ChEMBL_ID":"CHEMBL1743259","KEGG_DRUG":"D04105","DRUGBANK_ID":"DB09194","PUBCHEM_CID":"40589","SECONDARY_CAS_RN":"57775-22-1","MESH_SUPPLEMENTAL_RECORD_UI":"C013528"},"formularyStatus":[],"_enricherVersion":"v2","developmentCodes":[],"ownershipHistory":[],"publicationCount":37,"therapeuticAreas":["Neuroscience"],"atcClassification":{"source":"DrugCentral","atcCode":"N06AB09","allCodes":["N06AB09"]},"biosimilarFilings":[],"recentPublications":[],"companionDiagnostics":[],"genericManufacturerList":[],"status":"active","companyName":"","companyId":"","modality":"Small molecule","firstApprovalDate":"","aiSummary":"Clopramone is a small molecule. It is also known by the synonyms Etoperidona, Etoperidone, and Etoperidone.","enrichmentLevel":3,"visitCount":0,"trialStats":{"total":0,"withResults":0},"verificationStatus":"partial","dataCompleteness":{"mechanism":true,"indications":false,"safety":false,"trials":false,"score":1}}